Chiral separation by two-column, semi-continuous, open-loop simulated moving-bed chromatography

Journal of Chromatography A

Volumn 1217, Issue 33, 2010, Pages 5407-5419

  Araújo, João M M ^a   Rodrigues, Rui C R ^a   Eusébio, Mário F J ^a   Mota, José P B ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Chiral separation; Open loop configuration; Simulated moving bed; Two column process

Indexed keywords

CHIRAL SEPARATIONS; COLUMN OPERATIONS; COMPOSITION PROFILE; CYCLIC FLOW; ENANTIOMERIC ANALYSIS; EXPERIMENTAL APPARATUS; MATERIAL BALANCE; MONITORING SYSTEM; OPEN LOOPS; OPEN-LOOP CONFIGURATION; PHYSICAL REALIZATION; RAFFINATES; RECYCLING TECHNIQUES; RIGOROUS MODEL; SEMI-CONTINUOUS; SIMULATED MOVING BED; SIMULATED MOVING BED CHROMATOGRAPHY; TRANSFER ZONES; TWO-COLUMN PROCESS; TWO-PUMP; UV DETECTOR;

CHIRALITY; DESIGN; OPTIMIZATION;

COLUMN CHROMATOGRAPHY;

INTEGREX; PROLIFIT; REBOXETINE; UNCLASSIFIED DRUG; MORPHOLINE DERIVATIVE;

ARTICLE; AUTOMATION; CHIRALITY; CHROMATOGRAPHY; DRUG IDENTIFICATION; FEASIBILITY STUDY; FLUID FLOW; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ONLINE ANALYSIS; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS OPTIMIZATION; SEPARATION TECHNIQUE; SIMULATED MOVING BED CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY; VALIDATION PROCESS; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; PROCEDURES; REPRODUCIBILITY; STEREOISOMERISM; ULTRAVIOLET SPECTROPHOTOMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EQUIPMENT DESIGN; MORPHOLINES; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 77955058027     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.06.040     Document Type: Article

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