Thrombosis and obesity: Cellular bases

Thrombosis Research

Volumn 129, Issue 3, 2012, Pages 285-289

  Lorenzet, Roberto ^a   Napoleone, Emanuela ^a   Cutrone, Antonella ^a   Donati, Maria Benedetta ^a  

^a Fondazione di Ricerca e Cura Giovanni Paolo II   (Italy)

Author keywords

C reactive protein; CRP; ICAM 1; IL 6; inter cellular adhesion molecule; interleukin 6; matrix metallopeptidase 2; MCP 1; MMP 2; monocyte chemotactic protein 1; nitric oxide; NO; PAI 1; plasminogen activator inhibitor 1; TF; TGF ; tissue factor; TNF ; transforming growth factor ; tumor necrosis factor ; vascular cell adhesion molecule 1; VCAM 1

Indexed keywords

ADIPOCYTOKINE; ADIPSIN; APELIN; C REACTIVE PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; RESISTIN; RETINOL BINDING PROTEIN 4; THROMBOPLASTIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VASPIN;

ADIPOCYTE; ADIPOSE TISSUE; BLOOD CLOTTING; BODY WEIGHT; CARDIOVASCULAR DISEASE; GENE EXPRESSION; HUMAN; IN VIVO STUDY; INFLAMMATION; METABOLISM; NEOPLASM; OBESITY; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW; THROMBOSIS;

ADIPOKINES; ADIPOSE TISSUE; ANIMALS; ATHEROSCLEROSIS; BLOOD COAGULATION; HUMANS; INFLAMMATION MEDIATORS; NEOPLASMS; OBESITY; RISK FACTORS; SIGNAL TRANSDUCTION; THROMBOPLASTIN; THROMBOSIS;

EID: 84857786706     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.10.021     Document Type: Review

References (31)

1. M.M. Finucane, G.A. Stevens, M.J. Cowan, G. Danaei, J.K. Lin, and C.J. Paciorek Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9•1 million participants Lancet 377 2011 557 567
2. World Health Organization Global health risks: mortality and burden of disease attributable to selected major risks 2009 World Health Organization Geneva
3. E.E. Calle, M.J. Thun, J.M. Petrelli, C. Rodriguez, and C.W. Heath Jr. Body-mass index and mortality in a prospective cohort of U.S. adults N Engl J Med 341 15 1999 Oct 7 1097 1105 (Pubitemid 29466221)
4. S. Kenchaiah, J.C. Evans, D. Levy, P.W. Wilson, E.J. Benjamin, and M.G. Larson Obesity and the risk of heart failure N Engl J Med 347 5 2002 Aug 1 305 313 (Pubitemid 34815352)
5. L. Lind, A. Siegbahn, E. Ingelsson, J. Sundström, and J. Arnlöv A detailed cardiovascular characterization of obesity without the metabolic syndrome Arterioscler Thromb Vasc Biol 31 2011 e27 e34
6. T. Suganami, and Y. Ogawa Adipose tissue macrophages: their role in adipose tissue remodeling J Leukoc Biol 88 2010 33 39
7. V. Christiaens, and H.R. Lijnen Angiogenesis and development of adipose tissue Mol Cell Endocrinol 318 2010 2 9
8. V.Z. Rocha, and P. Libby Obesity, inflammation, and atherosclerosis Nat Rev Cardiol 6 2009 399 409
9. D.J. Loskutoff, and F. Samad The adipocyte and hemostatic balance in obesity: studies of PAI-1 Arterioscler Thromb Vasc Biol 18 1998 1 6 (Pubitemid 28047591)
10. H. Ghanim, A. Aljada, D. Hofmeyer, T. Syed, P. Mohanty, and P. Dandona Circulating mononuclear cells in the obese are in a proinflammatory state Circulation 110 2004 1564 1571 (Pubitemid 39297977)
11. H. Tilg, and A.R. Moschen Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nat Rev Immunol 6 2006 772 783 (Pubitemid 44453463)
12. N. Ouchi, J.L. Parker, J.J. Lugus, and K. Walsh Adipokines in inflammation and metabolic disease Nat Rev Immunol 11 2011 85 97
13. Y.J. Chen, L.Q. Zhang, G.P. Wang, H. Zeng, B. Lü, and X.L. Shen Adiponectin inhibits tissue factor expression and enhances tissue factor pathway inhibitor expression in human endothelial cells Thromb Haemost 100 2 2008 Aug 291 300
14. R. Yang, and L.A. Barouch Leptin signaling and obesity: cardiovascular consequences Circ Res 101 2007 545 559 (Pubitemid 351325872)
15. P.F. Bodary, S. Gu, Y. Shen, A.H. Hasty, J.M. Buckler, and D.T. Eitzman Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice Arterioscler Thromb Vasc Biol 25 2005 e119 e122
16. O. Gualillo, J.R. González-Juanatey, and F. Lago The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives Trends Cardiovasc Med 17 2007 275 283 (Pubitemid 350087698)
17. J. Beltowski Leptin and atherosclerosis Atherosclerosis 189 2006 47 60 (Pubitemid 44441296)
18. P. Singh, M. Hoffmann, R. Wolk, A.S. Shamsuzzaman, and V.K. Somers Leptin induces C-reactive protein expression in vascular endothelial cells Arterioscler Thromb Vasc Biol 27 2007 e302 e307
19. P. Singh, T.E. Peterson, K.R. Barber, F.S. Kuniyoshi, A. Jensen, and M. Hoffmann Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells Biochem Biophys Res Commun 392 2010 47 52
20. M. Nakata, T. Yada, N. Soejima, and I. Maruyama Leptin promotes aggregation of human platelets via the long form of its receptor Diabetes 48 1999 426 429 (Pubitemid 29061122)
21. J. Santos-Alvarez, R. Goberna, and V. Sánchez-Margalet Human leptin stimulates proliferation and activation of human circulating monocytes Cell Immunol 194 1999 6 11 (Pubitemid 29283971)
22. R. Lorenzet, E. Napoleone, A. Celi, G. Pellegrini, and A. Di Santo Cell-cell interaction and tissue factor expression Blood Coagul Fibrinol 9 suppl 1 1998 S49 S59
23. F. Samad, M. Pandey, and D.J. Loskutoff Tissue factor gene expression in the adipose tissues of obese mice Proc Natl Acad Sci U S A 95 1998 7591 7596 (Pubitemid 28293297)
24. C.W. Kopp, H.P. Kopp, S. Steiner, S. Kriwanek, K. Krzyzanowska, and A. Bartok Weight loss reduces tissue factor in morbidly obese patients Obes Res 11 2003 950 956 (Pubitemid 41137506)
25. E. Napoleone, A. Di Santo, C. Amore, G. Baccante, C. Di Febbo, and E. Porreca Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk? J Thromb Haemost 5 2007 1462 1468 (Pubitemid 46965376)
26. S. Rafail, K. Ritis, K. Schaefer, I. Kourtzelis, M. Speletas, and M. Doumas Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFalpha involvement Thromb Res 122 2008 366 375
27. P. Cirillo, V. Angri, S. De Rosa, G. Calì, G. Petrillo, and F. Maresca Pro-atherothrombotic effects of leptin in human coronary endothelial cells Thromb Haemost 103 2010 1065 1075
28. E.E. Calle, and M.J. Thun Obesity and cancer Oncogene 23 2004 6365 6378 (Pubitemid 39265505)
29. C. Garofalo, and E. Surmacz Leptin and cancer J Cell Physiol 207 2006 12 22
30. E. Napoleone, A. Cutrone, D. Cugino, M.C. Latella, F. Zurlo, L. Iacoviello, G. de Gaetano, M.B. Donati, and R. Lorenzet Leptin upregulates tissue factor expression in human breast cancer MCF-7 cells Thromb Res 2011 10.1016/j.thromres.2011.07.037
31. M.B. Donati, and R. Lorenzet The role of blood clotting in tumor metastasis: a case for tissue factor G. Lugassy, A. Falanga, A.K. Kakkar, F.R. Rickles, Thrombosis and Cancer 2004 Martin Dunitz Limited London 47 58