Stimulation of immunoreactive insulin release by glucose in rat brain synaptosomes

Neurochemical Research

Volumn 24, Issue 1, 1999, Pages 33-36

  Santos, Maria S ^b   Pereira, Emilia M ^a   Carvaho, Arsélio P ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c NONE

Author keywords

Brain insulin; Glucose; Insulin release; Synaptosomes

Indexed keywords

ANIMAL CELL; ARTICLE; BRAIN FUNCTION; BRAIN SYNAPTOSOME; DRUG RECEPTOR BINDING; EXOCYTOSIS; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; GLYCOLYSIS; IMMUNOREACTIVITY; INSULIN RELEASE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; SYNAPSE VESICLE;

ANIMALS; BRAIN; GLUCOSE; GLYCOLYSIS; INSULIN; IODOACETIC ACID; KINETICS; MALE; OLIGOMYCINS; POTASSIUM CYANIDE; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; SYNAPTOSOMES;

ANIMALIA;

EID: 0032956405     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020971812098     Document Type: Article

References (26)

1. Nehlig, A. 1997. Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia. Diabetes and Metab. 23:18-29.
2. Pressin, J. E. and Bell, G. I. 1992. Mammalian facilitative glucose transporter family: structure and molecular regulation Annu. Rev. Physiol. 54:911-930.
3. Lee, H. T. and Bondy, C. A. 1993. Ischemic injury induces brain glucose transporter gene expression. Endocrinology 133:2540-2544.
4. Gerhart, D. Z., Leino, R. L., Taylor, W. E., Borson, N. D., and Drewes, L. R. 1994. GLUT1 and GLU3 gene expression in gerbil brain following brief ischemia-an in situ hybridization study. Brain Res. 25:313-322.
5. Nagamatsu, S., Sawa, H., Inoue, N., Nakamichi, Y., Takeshima, H., and Hoshino, T. 1994. Gene expression of GLU3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat brain. Biochem. J. 300: 125-131.
6. Vannucci, S. 1994. Developmental expression of GLUT1 and GLUT3 glucose transporters in rat brain. J. Neurochem. 62:240-246.
7. Henneberg, N. and Hoyer, S. 1994. Short-term or long-term intracerebroventricular (i.c.v.) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat. Neurosc. Lett. 175:153-156.
8. Hoyer, S., Prem, L., Sorbi, S., and Amaducci, L. 1993. Stimulation of glycolytic key enzymes in cerebral cortex by insulin. NeuroReport 4:991-993.
9. Schwartz, M. W., Figlewicz, D., P., Baskin, D. G., Woods, S. C., and Porte, D. 1992. Insulin in the brain: a hormonal regulator of energy metabolism. Endocrine Rev. 13:387-414.
10. Baskin, D. G., Wilcox, B. J., Figlewicz, D. P., and Dorsa, D. M. 1988. Insulin and insulin-like growth factors in the CNS. TINS 11:107-111.
11. Wozniak, M., Rydzewski, B., Baker, S. P. and Raizada, M. K. 1993. The cellular and physiological actions of insulin in the central nervous system. Neurochem. Int. 22:1-10.
12. Devaskar, S. U., Giddings, S. J., Rajakumar, P. A., Carnaghi, L. R., Menon, R. K., and Zahm, D. S. 1994. Insulin gene expression and insulin synthesis in mammalian neuronal cells. J. Biol. Chem. 269:8445-8454.
13. Wei, L., Matsumoto, H., and Rhoads, D. E. 1990. Release of immunoreactive insulin from rat brain synaptosomes under depolarizing conditions. J. Neurochem. 54:1661-1665.
14. Havrankova, J., Schmechel, D., Roth, J., and Brownstein, M. 1978. Identification of insulin in rat brain. Proc. Natl. Acad. Sci. USA. 75:5337-5741.
15. Hedeskov, C. J. 1980. Mechanism of glucose-induced insulin secretion. Physiol. Reviews 60:442-509.
16. Clarke, D. W., Mudd, L., Boyd, F., Fields, M., and Raizada, M. K. 1986. Insulin is released from rat brain neuronal cells in culture. J. Neurochem. 47:831-836.
17. Swanson, R. A., Yu, A. C. H., Sharp, F. R., and Chan, P. H. 1989. Regulation of glycogen content in primary astrocyte culture: effects of glucose analogues, phenobarbital, and methionine sulfoximine. J. Neurochem. 52:1359-1365.
18. Kauppinen, R. A. and Nicholls, D. G. 1986. Failure to maintain glycolysis in anoxic nerve terminals. J. Neurochem. 47:1864-1869.
19. Lemay, D. R., Gehau, L. R., Zelenock, G. B., and D'Alecy, L. G. 1988. Insulin administration protects neurological function in cerebral ischemia in rats. Stroke 19:1411-1419.
20. Strong, A. J., Fairfield, J. E., Monteiro, E., Kirby, M., Hogg, A. R., Shape, M., and Rossfield, L. 1990. J. Neurol. Neurosurg. Psychiatry 53:847-853.
21. Zhu, C. Z. and Auer, R. N. 1994. Intraventricular administration of insulin and IGF-1 in transient forebrain ischemia. J. Cereb. Blood Flow Metab. 14:237-242.
22. Degen, D. B., Frolich, L., Hoyer, S. and Riederer, P. 1995. Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders. J. Neural. Transm. 46:139-147.
23. Hoyer, S. 1996. Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. Acta Neurol. Scand. 165:18-24.
24. Hajos, F. 1975. An improved method for the preparation of synaptosomal fractions in high purity. Brain Res. 93:485-499.
25. Tesoriere, G., Vento, R., Calvaruso, G., Taibi, G., and Giuliano, M. 1992. Identification of insulin in chick embryo retina during development and its inhibitory effect on DNA synthesis. J. Neurochem. 58:1353-1359.
26. Santos, M. S., Moreno, A. J., and Carvalho, A. P. 1996. Relationships between ATP depletion, membrane potential, and the release of neurotransmitters in rat nerve terminals: an in vitro study under conditions that mimic anoxia, hypoglycemia and ischemia. Stroke 27:941-970.