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Volumn 9, Issue 2, 2012, Pages 138-139

RIPpers at the membrane - A brief history of APP secretases, their substrates and their functions

(1)  Hartmann, Dieter a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID BETA PROTEIN; BETA SECRETASE 1; CELL ADHESION MOLECULE; GAMMA SECRETASE; NEU DIFFERENTIATION FACTOR; NOTCH RECEPTOR; SECRETASE; SODIUM CHANNEL; AMYLOID;

EID: 84857766941     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720512799361628     Document Type: Editorial
Times cited : (2)

References (20)
  • 1
    • 0034681260 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
    • Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100: 391-398 (2000).
    • (2000) Cell , vol.100 , pp. 391-398
    • Brown, M.S.1    Ye, J.2    Rawson, R.B.3    Goldstein, J.L.4
  • 3
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang J, Lemaire H-G, Unterbeck A, Salbaum JM, Masters CL, Grzeschik K-H, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733-736 (1987).
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3    Salbaum, J.M.4    Masters, C.L.5    Grzeschik, K.-H.6
  • 5
    • 0034669031 scopus 로고    scopus 로고
    • A common enzyme connects notch signaling and Alzheimer's disease
    • Kopan R, Goate A. A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev 2000 14: 2799-2806 (2000).
    • (2000) Genes Dev , vol.2000 , Issue.14 , pp. 2799-2806
    • Kopan, R.1    Goate, A.2
  • 6
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    • Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398: 513-517 (1999).
    • (1999) Nature , vol.398 , pp. 513-517
    • Wolfe, M.S.1    Xia, W.2    Ostaszewski, B.L.3    Diehl, T.S.4    Kimberly, W.T.5    Selkoe, D.J.6
  • 7
    • 0033535504 scopus 로고    scopus 로고
    • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    • De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398: 518-522 (1999).
    • (1999) Nature , vol.398 , pp. 518-522
    • de Strooper, B.1    Annaert, W.2    Cupers, P.3    Saftig, P.4    Craessaerts, K.5    Mumm, J.S.6
  • 8
    • 78049374467 scopus 로고    scopus 로고
    • Novel research horizons for presenilins and γ-secretases in cell biology and disease
    • De Strooper B, Annaert W. Novel research horizons for presenilins and γ-secretases in cell biology and disease. Annu Rev Cell Dev Biol 26: 235-260 (2010).
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 235-260
    • de Strooper, B.1    Annaert, W.2
  • 9
    • 0029045064 scopus 로고
    • ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain
    • Wolfsberg TG, Straight PD, Gerena RL, Huovila AP, Primakoff P, Myles DG, et al. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev Biol 169: 378-383 (1995).
    • (1995) Dev Biol , vol.169 , pp. 378-383
    • Wolfsberg, T.G.1    Straight, P.D.2    Gerena, R.L.3    Huovila, A.P.4    Primakoff, P.5    Myles, D.G.6
  • 10
    • 42149110867 scopus 로고    scopus 로고
    • Part-time α-secretases: The functional biology of ADAM 9, 10 and 17
    • Deuss M, Reiss K, Hartmann D. Part-time α-secretases: the functional biology of ADAM 9, 10 and 17. Curr Alzheimer Res 5:187-201 (2008).
    • (2008) Curr Alzheimer Res , vol.5 , pp. 187-201
    • Deuss, M.1    Reiss, K.2    Hartmann, D.3
  • 11
    • 57649217285 scopus 로고    scopus 로고
    • The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology
    • Cole SL, Vassar R. The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology. J Biol Chem 283: 29621-29625 (2008).
    • (2008) J Biol Chem , vol.283 , pp. 29621-29625
    • Cole, S.L.1    Vassar, R.2
  • 12
    • 0030671560 scopus 로고    scopus 로고
    • HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
    • Li X, Greenwald I. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc Natl Acad Sci USA 94: 12204-9 (1997).
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12204-12209
    • Li, X.1    Greenwald, I.2
  • 13
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl G, Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398: 522-5 (1999).
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 14
    • 2942557122 scopus 로고    scopus 로고
    • Gamma-secretase: Proteasome of the membrane?
    • Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5: 499-504 (2004).
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 499-504
    • Kopan, R.1    Ilagan, M.X.2
  • 15
    • 3242713169 scopus 로고    scopus 로고
    • Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
    • Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Hum Mol Genet 13: 1321-1331 (2004).
    • (2004) Hum Mol Genet , vol.13 , pp. 1321-1331
    • Tournoy, J.1    Bossuyt, X.2    Snellinx, A.3    Regent, M.4    Garmyn, M.5    Serneels, L.6
  • 17
    • 24744449320 scopus 로고    scopus 로고
    • Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
    • Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, et al. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280: 30797-30806 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 30797-30806
    • Dominguez, D.1    Tournoy, J.2    Hartmann, D.3    Huth, T.4    Cryns, K.5    Deforce, S.6
  • 19
    • 76849086405 scopus 로고    scopus 로고
    • The secretases: Enzymes with therapeutic potential in Alzheimer disease
    • De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6: 99-107 (2010).
    • (2010) Nat Rev Neurol , vol.6 , pp. 99-107
    • de Strooper, B.1    Vassar, R.2    Golde, T.3
  • 20
    • 42149186414 scopus 로고    scopus 로고
    • Production and fate of amyloid peptides: Recent advances and perspectives
    • Checler F. Production and fate of amyloid peptides: recent advances and perspectives. Curr Alzheimer Res 5: 90-1 (2008).
    • (2008) Curr Alzheimer Res , vol.5 , pp. 90-91
    • Checler, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.