A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease

ChemMedChem

Volumn 7, Issue 3, 2012, Pages 391-395

  Contino, Marialessandra ^a   Cantore, Mariangela ^a   Capparelli, Elena ^a   Perrone, Maria Grazia ^a   Niso, Mauro ^a   Inglese, Carmela ^a   Berardi, Francesco ^a   Leopoldo, Marcello ^a   Perrone, Roberto ^a   Colabufo, Nicola Antonio ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Alzheimer's disease; Benzopyranes; Everted gut sac assay; Multidrug resistance associated proteins; P glycoprotein stimulators

Indexed keywords

(3,4 DIHYDRO 6,7 DIMETHOXYISOQUINOLIN 2(1H) YL)(6 METHOXY 2H CHROMEN 3 YL)METHANONE; 1,2,3,4 TETRAHYDRO 2 ((3,4 DIHYDRO 6 METHOXY 2H CHROMEN 3 YL)METHYL) 6,7 DIMETHOXYISOQUINOLINE; 1,2,3,4 TETRAHYDRO 2 ((E) 3 (2,3 DIHYDRO 8 METHOXYCHROMEN 4 YLIDENE)PROPYL) 6,7 DIMETHOXYISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 ((6 METHOXY 2H CHROMEN 3 YL)METHYL)ISOQUINOLINE; 3,4 DIHYDRO 6,7 DIMETHOXYISOQUINOLIN 2(1H) YL)(3,4 DIHYDRO 6 METHOXY 2H CHROMEN 3 YL)METHANONE; ABC TRANSPORTER; AMYLOID BETA PROTEIN; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; ELACRIDAR; GLYCOPROTEIN P INHIBITOR; LIGAND; MC 18; PYRAN DERIVATIVE; TARIQUIDAR; TOXIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ALZHEIMER DISEASE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CELL MEMBRANE; DRUG SYNTHESIS; ENERGY; HYDROLYSIS; INTESTINE CELL; KIDNEY CELL; LIPOPHILICITY; LIVER CELL; PLACENTA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BENZOPYRANS; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN; CELL LINE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCEINS; FLUORESCENT DYES; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEUROPROTECTIVE AGENTS; P-GLYCOPROTEIN; RHODAMINES;

EID: 84857749471     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100469     Document Type: Article

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