Anti-inflammatory effects of shea butter through inhibition of iNOS, COX-2, and cytokines via the Nf-Kb pathway in Lps-activated J774 macrophage cells

Journal of Complementary and Integrative Medicine

Volumn 9, Issue 1, 2012, Pages

  Verma, Nandini ^a   Chakrabarti, Rina ^b   Das, Rakha H ^c   Gautam, Hemant K ^a  

^a Institute of Genomics and Integrative Biology   (India)

^b UNIVERSITY OF DELHI   (India)

^c GGSI University   (India)

Author keywords

Cyclooxygenase 2; Inducible nitric oxide synthase; Nuclear factor kappa b; Pro inflammatory cytokines

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VITELLARIA PARADOXA EXTRACT; BIOLOGICAL MARKER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ENZYME INHIBITION; INFLAMMATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECT; EVALUATION; MACROPHAGE; MEDICINAL PLANT; METABOLISM; PLANT SEED; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAPOTACEAE; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL LINE; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-12; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANTS, MEDICINAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SAPOTACEAE; SEEDS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84857743104     PISSN: None     EISSN: 15533840     Source Type: Journal    
DOI: 10.1515/1553-3840.1574     Document Type: Article

References (18)

1. Akihisa, T., Kojima, N., Katoh, N., Kikuchi, T., Fukatsu, M., Shimizu, N., and Masters, E. T. (2011). Triacylglycerol and Triterpene Ester Composition of Shea Nuts from Seven African Countries. Journal of Oleo Science. 60, 385-391.
2. Akihisa, T., Kojima, N., Kikuchi, T., Yasukawa, K., Tokuda, H., Masters, E. T., Manosroi, A., and Manosroi, J. (2010) Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science, 59, 6273-280.
3. Badifu, G. I. O., 1989. Lipid composition of Nigerian Butyrospermum paradoxum kernel. Journal of Food Composition Annals 2, 238-244.
4. Chaudhury I., Sunil K. Raghav, Hemant K. Gautam, Hasi R. Das and Rakha H. Das (2006). Suppression of inducible nitric oxide synthase by 10-23 DNAzymes in murine macrophage. FEBS Letters 580 (8) 2046-2052.
5. Chen, F., Demers, L. M. & Shi, X. (2002). Upstream signal transduction of NF-κB activation. Inflamm and Allergy, 1, 137-149.
6. Coker, R. K., & Laurent, G. J. (1998). Pulmonary fibrosis: cytokines in the balance. Eur Respir J, 11, 1218-1221. (Pubitemid 28298579)
7. Ghosh, S. & Karin, M. (2002) Missing pieces in the NF-κB puzzle. Cell, 109, 81-96.
8. Hall, J. B., Aebischer, D. P., Tomlinson, H. F., Osei-Amaning, E. & Hindle, J. R. (1996). Vitellaria paradoxa. A monograph. Bangor, UK: University of Wales, School of Agricultural and Forest Sciences.
9. Harris SG, Padilla J, Koumas L, Ray D, Phipps RP. (2002). Prostaglandins as modulators of immunity. Trends in Immunol, 23, 144-150. (Pubitemid 34178297)
10. Harvey, A. L., (2008) Natural products in drug discovery. Drug Discov Today, 13, 894-901.
11. Kerharo, J., "Note sur les excipients pour pommades", Centre de documentation pharmaceutique et chimique des troupes coloniales, Marseille, 1942.
12. Lawrence, T., Gilroy, D. W., Colville-Nash P. R. & Willoughby, D. A. (2001). Possible new role for NF-κB in the resolution of inflammation. Nat Med; 7, 1291-1297. (Pubitemid 34007932)
13. Lowenstein, C. J., Hill, S. L., Walker, A. L., Wu, J., Allen, G., Landavere, M., et al. (1996). Nitric oxide inhibits viral replication in murine myocarditis. J Clin Invest; 97, 1837-1843. (Pubitemid 26129869)
14. Steven, M., Zeev, W., Nissim, G., 2003. Phenolic constituents of shea (Vitellria paradoxa) kernel. Journal of Agriculture and Food Chemistry. 51, 6268-6273.
15. Thioune, O., Ahodikpe, D., Dieng, M., Diop, A. B., Ngom, S. & Lo, I. (2000). Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat). Dakar Med, 45, 113-116.
16. Verma, N., Tripathi, S. K., Sahu, D., Das, H. R. & Das, R. H. (2010) Mol Cell Biochem, 336, 127-135.
17. Verstak, B., Hertzog, P., Mansell, A., 2007. Toll-like receptor signalling and the clinical benefits that lie within. Inflammation Research 56, 1-10. (Pubitemid 46356229)
18. Wiesman, Z., Maranz, S., Bianchi, G., Bisgaard, J., 2003. Chemical analysis of fruit of Vitellaria paradoxa. In improved management of Agroforestry parkland system in sub-saharan Africa. Final report, Teklehaimanat. Z. Ed: School of Agricultural and Forest Sciences, University of Wales: Banagor U. K. pp. 131-139.