Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

BMC Medicine

Volumn 10, Issue , 2012, Pages

  Bowerman, Melissa ^a,b   Murray, Lyndsay M ^a   Boyer, Justin G ^a,b   Anderson, Carrie L ^a   Kothary, Rashmi ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Fasudil; Muscle; NMJ; Spinal muscular atrophy; Survival motor neuron protein

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; FASUDIL; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SURVIVAL MOTOR NEURON PROTEIN 1; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; DRUG DERIVATIVE; MYOGENIN; SURVIVAL MOTOR NEURON PROTEIN 2;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; FEMALE; KAPLAN MEIER METHOD; LIFESPAN; LOG RANK TEST; MOTONEURON; MOUSE; MUSCLE CELL; MUSCLE DEVELOPMENT; NERVE ENDING; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SKELETAL MUSCLE; SPINAL MUSCULAR ATROPHY; SURVIVAL; UPREGULATION; ANIMAL; ANTERIOR HORN CELL; C57BL MOUSE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; GAIT; GROWTH, DEVELOPMENT AND AGING; LONGEVITY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPINAL CORD; WEIGHT GAIN;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; ANTERIOR HORN CELLS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GAIT; LONGEVITY; MICE; MICE, INBRED C57BL; MOTOR ENDPLATE; MOTOR NEURONS; MUSCLE DEVELOPMENT; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; MUSCULAR ATROPHY, SPINAL; MYOGENIN; PHENOTYPE; SPINAL CORD; SURVIVAL ANALYSIS; SURVIVAL OF MOTOR NEURON 2 PROTEIN; WEIGHT GAIN;

EID: 84857711556     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-10-24     Document Type: Article

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