Mouse survival motor neuron alleles that mimic SMN2 splicing and are inducible rescue embryonic lethality early in development but not late

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Hammond, Suzan M ^a,b   Gogliotti, Rocky G ^a,b   Rao, Vamshi ^a,b   Beauvais, Ariane ^c,d   Kothary, Rashmi ^c,d   DiDonato, Christine J ^a,b  

^a Children's Memorial Research Center   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; NEOMYCIN; SURVIVAL MOTOR NEURON PROTEIN 2; INTEGRASE; SMN1 PROTEIN, MOUSE; SURVIVAL MOTOR NEURON PROTEIN 1;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DISEASE MODEL; DISEASE SEVERITY; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; EXON; GENETIC SELECTION; GESTATION PERIOD; HOMOZYGOSITY; IN VITRO STUDY; IN VIVO STUDY; INTRON; LOXP SITE; MOTONEURON; MOUSE; NONHUMAN; PROTEIN INDUCTION; PROTEIN PROCESSING; SPINAL MUSCULAR ATROPHY; SURVIVAL MOTONEURON; ALTERNATIVE RNA SPLICING; ANIMAL; C57BL MOUSE; CYTOLOGY; FEMALE; FIBROBLAST; GENETICS; HOMOZYGOTE; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ALLELES; ALTERNATIVE SPLICING; ANIMALS; EXONS; FEMALE; FIBROBLASTS; HOMOZYGOTE; INTEGRASES; INTRONS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL OF MOTOR NEURON 1 PROTEIN; SURVIVAL OF MOTOR NEURON 2 PROTEIN;

EID: 78650827775     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015887     Document Type: Article

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