Concentrated dispersions of equilibrium protein nanoclusters that reversibly dissociate into active monomers

ACS Nano

Volumn 6, Issue 2, 2012, Pages 1357-1369

  Johnston, Keith P ^a   Maynard, Jennifer A ^a,b   Truskett, Thomas M ^a,b   Borwankar, Ameya U ^a   Miller, Maria A ^a   Wilson, Brian K ^a   Dinin, Aileen K ^a   Khan, Tarik A ^a   Kaczorowski, Kevin J ^a  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

colloidal forces; depletion attraction; drug delivery; nanocluster; protein; protein stability

Indexed keywords

ACID MODIFICATION; ACTIVE PROTEINS; ANTIBODY THERAPEUTICS; BIOLOGICAL ASSAYS; BIOLOGICAL THERAPEUTICS; BIOPHYSICAL ANALYSIS; BOVINE SERUM ALBUMINS; CHARGED PROTEINS; COLLOID INTERACTIONS; COLLOIDAL FORCES; CONFORMATIONAL STABILITIES; DEPLETION ATTRACTION; ELECTROSTATIC REPULSION; FREE-ENERGY MODEL; HIGH CONCENTRATION; IMMUNOGLOBULIN G; IN-VITRO; IN-VIVO; ISO-ELECTRIC POINTS; LOW VISCOSITY; POLYCLONAL; PROTEIN CLUSTERS; PROTEIN MOLECULES; PROTEIN STABILITY; SDS-PAGE;

AMINO ACIDS; COMPUTER SIMULATION; DISEASES; DISPERSIONS; DRUG DELIVERY; FRACTAL DIMENSION; MAMMALS; MONOCLONAL ANTIBODIES; MONOMERS; NANOCLUSTERS;

PROTEINS;

BUFFER; DRUG CARRIER; NANOMATERIAL; PROTEIN; TREHALOSE;

ANIMAL; ARTICLE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; MOUSE; PROTEIN CONFORMATION; PROTEIN STABILITY;

ANIMALS; BUFFERS; CATTLE; DRUG CARRIERS; MICE; MODELS, MOLECULAR; NANOSTRUCTURES; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEINS; TREHALOSE;

EID: 84857709516     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn204166z     Document Type: Article

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