Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification

Human Molecular Genetics

Volumn 21, Issue 6, 2012, Pages 1402-1409

  Tveten, Kristian ^a   Holla, Øystein L ^a   Cameron, Jamie ^a   Strøm, Thea Bismo ^a   Berge, Knut Erik ^a   Laerdahl, Jon K ^a,b   Leren, Trond P ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

KEXIN; LOW DENSITY LIPOPROTEIN RECEPTOR; SUBTILISIN;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CONTROLLED STUDY; ENDOSOMAL ACIDIFICATION; ENDOSOME; FEMALE; LIGAND BINDING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION;

ACIDS; ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; CELLS, CULTURED; CHO CELLS; CRICETINAE; ENDOSOMES; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; LYSOSOMES; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROPROTEIN CONVERTASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, LDL; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 84857684478     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr578     Document Type: Article

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