메뉴 건너뛰기




Volumn 52, Issue 10, 2011, Pages 1787-1794

Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

Author keywords

Endosomes; Low density lipoprotein; Proprotein convertase subtilisin kexin type 9; Recycling; Sorting

Indexed keywords

CHIMERIC PROTEIN; ENZYME PRECURSOR; HISTIDINE; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9; PROTEIN PCSK9; UNCLASSIFIED DRUG;

EID: 80053192318     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M018093     Document Type: Article
Times cited : (55)

References (23)
  • 1
    • 0000600880 scopus 로고    scopus 로고
    • Familial hypercholesterolemia
    • C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. McGraw-Hill, NY
    • Goldstein, J. L., H. H. Hobbs, and M. S. Brown. 2001. Familial hypercholesterolemia. In The Metabolic and Molecular Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. McGraw-Hill, NY. 2863-2914.
    • (2001) The Metabolic and Molecular Basis of Inherited Disease , pp. 2863-2914
    • Goldstein, J.L.1    Hobbs, H.H.2    Brown, M.S.3
  • 2
    • 70449368195 scopus 로고    scopus 로고
    • The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis
    • Mousavi, S. A., K. E. Berge, and T. P. Leren. 2009. The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis. J. Intern. Med. 266:507-519.
    • (2009) J. Intern. Med. , vol.266 , pp. 507-519
    • Mousavi, S.A.1    Berge, K.E.2    Leren, T.P.3
  • 4
    • 34547108600 scopus 로고    scopus 로고
    • Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
    • DOI 10.1074/jbc.M702027200
    • Zhang, D. W., T. A. Lagace, R. Garuti, Z. Zhao, M. McDonald, J. D. Horton, J. C. Cohen, and H. H. Hobbs. 2007. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J. Biol. Chem. 282:18602-18612. (Pubitemid 47100234)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.25 , pp. 18602-18612
    • Zhang, D.-W.1    Lagace, T.A.2    Garuti, R.3    Zhao, Z.4    McDonald, M.5    Horton, J.D.6    Cohen, J.C.7    Hobbs, H.H.8
  • 6
    • 34247892364 scopus 로고    scopus 로고
    • The Crystal Structure of PCSK9: A Regulator of Plasma LDL-Cholesterol
    • DOI 10.1016/j.str.2007.04.004, PII S0969212607001463
    • Piper, D. E., S. Jackson, Q. Liu, W. G. Romanow, S. Shetterly, S. T. Thibault, B. Shan, and N. P. C. Walker. 2007. The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol. Structure. 15:545-552. (Pubitemid 46702689)
    • (2007) Structure , vol.15 , Issue.5 , pp. 545-552
    • Piper, D.E.1    Jackson, S.2    Liu, Q.3    Romanow, W.G.4    Shetterly, S.5    Thibault, S.T.6    Shan, B.7    Walker, N.P.C.8
  • 8
    • 48249115641 scopus 로고    scopus 로고
    • Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
    • Cameron, J., Ø. L. Holla, K. E. Berge, M. A. Kulseth, T. Ranheim, T. P. Leren, and J. K. Laerdahl. 2008. Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion. FEBS J. 275:4121-4133.
    • (2008) FEBS J. , vol.275 , pp. 4121-4133
    • Cameron, J.1    Holla, Ø.L.2    Berge, K.E.3    Kulseth, M.A.4    Ranheim, T.5    Leren, T.P.6    Laerdahl, J.K.7
  • 9
    • 51349161358 scopus 로고    scopus 로고
    • Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
    • Zhang, D. W., R. Garuti, W. J. Tang, J. C. Cohen, and H. H. Hobbs. 2008. Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor. Proc. Natl. Acad. Sci. USA. 105:13045-13050.
    • (2008) Proc. Natl. Acad. Sci. USA. , vol.105 , pp. 13045-13050
    • Zhang, D.W.1    Garuti, R.2    Tang, W.J.3    Cohen, J.C.4    Hobbs, H.H.5
  • 11
    • 79953136043 scopus 로고    scopus 로고
    • A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor
    • Yamamoto, T., C. Lu, and R. O. Ryan. 2011. A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor. J. Biol. Chem. 286:5464-5470.
    • (2011) J. Biol. Chem. , vol.286 , pp. 5464-5470
    • Yamamoto, T.1    Lu, C.2    Ryan, R.O.3
  • 13
    • 33947134366 scopus 로고    scopus 로고
    • Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
    • Holla, Ø. L., J. Cameron, K. E. Berge, T. Ranheim, and T. P. Leren. 2007. Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly. BMC Cell Biol. 8:9.
    • (2007) BMC Cell Biol. , vol.8 , pp. 9
    • Holla, Ø.L.1    Cameron, J.2    Berge, K.E.3    Ranheim, T.4    Leren, T.P.5
  • 14
    • 33644863652 scopus 로고    scopus 로고
    • Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress
    • DOI 10.1074/jbc.M507071200
    • Sørensen, S., T. Ranheim, K. S. Bakken, T. P. Leren, and M. A. Kulseth. 2006. Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress. J. Biol. Chem. 281:468-476. (Pubitemid 43671209)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.1 , pp. 468-476
    • Sorensen, S.1    Ranheim, T.2    Bakken, K.S.3    Leren, T.P.4    Kulseth, M.A.5
  • 16
    • 73749086245 scopus 로고    scopus 로고
    • A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9
    • Holla, Ø. L., T. B. Strøm, J. Cameron, K. E. Berge, and T. P. Leren. 2010. A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9. Mol. Genet. Metab. 99:149-156.
    • (2010) Mol. Genet. Metab. , vol.99 , pp. 149-156
    • Holla, Ø.L.1    Strøm, T.B.2    Cameron, J.3    Berge, K.E.4    Leren, T.P.5
  • 20
    • 0037147281 scopus 로고    scopus 로고
    • Structure of the LDL receptor extracellular domain at endosomal pH
    • DOI 10.1126/science.1078124
    • Rudenko, G., L. Henry, K. Henderson, K. Ichtchenko, M. S. Brown, J. L. Goldstein, and J. Deisenhofer. 2002. Structure of the LDL receptor extracellular domain at endosomal pH. Science. 298:2353-2358. (Pubitemid 36014201)
    • (2002) Science , vol.298 , Issue.5602 , pp. 2353-2358
    • Rudenko, G.1    Henry, L.2    Henderson, K.3    Ichtchenko, K.4    Brown, M.S.5    Goldstein, J.L.6    Deisenhofer, J.7
  • 23
    • 0026056610 scopus 로고
    • Anomalous behaviour of a protein during SDS/PAGE corrected by chemical modification of carboxylic groups
    • Matagne, A., B. Joris, and J. M. Frère. 1991. Anomalous behaviour of a protein during SDS/PAGE corrected by chemical modification of carboxylic groups. Biochem. J. 280:553-556.
    • (1991) Biochem. J. , vol.280 , pp. 553-556
    • Matagne, A.1    Joris, B.2    Frère, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.