Active site mutations change the cleavage specificity of neprilysin

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Sexton, Travis ^a   Hitchcook, Lisa J ^a   Rodgers, David W ^a   Bradley, Luke H ^a   Hersh, Louis B ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; ENKEPHALIN; INSULIN; INSULIN B CHAIN; LEUCINE; MEMBRANE METALLOENDOPEPTIDASE; MUTANT PROTEIN; PHENYLALANINE; SERINE; UNCLASSIFIED DRUG; PEPTIDE; PROTEINASE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; CATALYSIS; CHEMISTRY; GENE VECTOR; GENETICS; HYDROLYSIS; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; TIME;

CATALYSIS; CATALYTIC DOMAIN; ENDOPEPTIDASES; GENETIC VECTORS; HUMANS; HYDROLYSIS; INSULIN; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEPRILYSIN; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS;

EID: 84857614739     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032343     Document Type: Article

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