Targeting radioresistant osteosarcoma cells with parthenolide

Journal of Cellular Biochemistry

Volumn 113, Issue 4, 2012, Pages 1282-1291

  Zuch, Daniel ^a   Giang, An Hoa ^a   Shapovalov, Yuriy ^a   Schwarz, Edward ^a   Rosier, Randy ^a   O'Keefe, Regis ^a   Eliseev, Roman A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

CANCER STEM CELLS; NF B; OSTEOSARCOMA; PARTHENOLIDE; RADIATION; ROS

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PARTHENOLIDE;

ARTICLE; CANCER STEM CELL; CELL DEATH; CELL POPULATION; CELL VIABILITY; CHEMORADIOTHERAPY; DRUG MECHANISM; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; MOLECULAR LIBRARY; OSTEOSARCOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIOSENSITIVITY; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; BONE NEOPLASMS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NEOPLASTIC STEM CELLS; NF-KAPPA B; OSTEOSARCOMA; RADIATION TOLERANCE; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84857607728     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24002     Document Type: Article

References (51)

1. Ailles LE, Weissman IL,. 2007. Cancer stem cells in solid tumors. Curr Opin Biotechnol 18 (5): 460-466.
2. Al-Hajj M, Clarke MF,. 2004. Self-Renewal and solid tumor stem cells. Oncogene 23 (43): 7274-7282.
3. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN,. 2006. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756-760.
4. Basu S, Rosenzweig KR, Youmell M, Price BD,. 1998. The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage. Biochem Biophys Res Commun 247 (1): 79-83.
5. Chen CT, Hsu SH, Wei YH,. 2010. Upregulation of mitochondrial function and antioxidant defense in the differentiation of stem cells. Biochim Biophys Acta 1800: 257-263.
6. Caraway HE, Gore SD,. 2007. Addition of histone deacetylase inhibitors in combination therapy. J Clin Oncol 25: 1955-1956.
7. Chendil D, Ranga RS, Meigooni D, Sathishkumar S, Ahmed MM,. 2004. Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene 23: 1599-1607.
8. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM,. 2006. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66: 9339-9344.
9. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S,. 2003. MAPK pathways in radiation responses. Oncogene 22: 5885-5896.
10. Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas F, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF,. 2009. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458: 780-783.
11. Duan X, Jia SF, Zhou Z, Langley RR, Bolontrade MF, Kleinerman ES,. 2004. Association of αvβ3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells. Clin Exp Metastasis 21 (8): 747-753.
12. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF,. 2004. IkappaB-kinase beta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Nat Acad Sci USA 101: 2452-2457.
13. Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN,. 2005. Increased radiation-induced apoptosis of SaOS2 cells via inhibition of NFκB: A role for c-Jun N-terminal kinase. J Cell Biochem 96: 1262-1273.
14. Fargeas CA, Corbeil D, Huttner WB,. 2003. AC133 antigen, CD133, prominin-1, prominin-2, etc.: Prominin family gene products in need of a rational nomenclature. Stem Cells 21: 506-508.
15. Fuchs B, Pritchard DJ,. 2002. Etiology of osteosarcoma. Clin Orthop Relat Res 397: 40-52.
16. Gibbs CP, Kukekov VG, Reith JD, Tchigrinova O, Suslov ON, Scott EW, Ghivizzani SC, Ignatova TN, Steindler DA,. 2005. Stem-like cells in bone sarcomas: Implications for tumorigenesis. Neoplasia 7: 967-976.
17. Goorin AM, Schwartzentruber DJ,. 2003. Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma. J Clin Oncol 21: 1574-1580.
18. Greten FR, Karin M,. 2005. NF-κB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759.
19. Hanahan D, Weinberg RA,. 2000. The hallmarks of cancer. Cell 100: 57-70.
20. Hehner SP, Hofmann TG, Droge W, Schmitz ML,. 1999. The anti-inflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. J Immunol 163: 5617-5623.
21. Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK,. 2004. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci USA 101: 14223-14228.
22. Ischenko I, Seeliger H, Schaffer M, Jauch KW, Bruns CJ,. 2008. Cancer stem cells: How can we target them ? Curr Med Chem 15: 3171-3184.
23. Kishida Y, Yoshikawa H, Myoui A,. 2007. Parthenolide, a natural inhibitor of nuclear factor-κB, inhibits lung colonization of murine osteosarcoma cells. Clin Cancer Res 13: 59-67.
24. Koch U, Krause M, Baumann M,. 2010. Cancer stem cells at the crossroads of current cancer therapy failures-radiation oncology perspective. Semin Cancer Biol 20 (2): 116-124.
25. Koshkina NV, Rao-Bindal K, Kleinerman ES,. 2011. Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. Cancer 117: 3457-3467.
26. Kuwabara M, Takahashi K, Inanami O,. 2003. Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Rad Res 44: 203-209.
27. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM,. 2001. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol 8: 759-766.
28. Li Q, Withoff S, Verma I,. 2005. Inflammation-associated cancer: NF-κB is the lynchpin. Trends Immunol 26: 318-325.
29. Lisle JW, Choi JY, Horton JA, Allen MJ, Damron TA,. 2008. Metastatic osteosarcoma gene expression differs in vitro and in vivo. Clin Orthop Relat Res 466: 2071-2080.
30. Liu B, Shuai K,. 2001. Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. J Biol Chem 276: 36624-36631.
31. Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin D, Black KL, Yu JS,. 2006. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 5: 67.
32. Lou H, Dean M,. 2007. Targeted therapy for cancer stem cells: The patched pathway and ABC transporters. Oncogene 26: 1357-1360.
33. Mohseny AB, Szuhai K, Romeo S, Buddingh EP, Briaire-de Bruijn I, de Jong D, van Pel M, Cleton-Jansen AM, Hogendoorn PC,. 2009. Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2. J Pathol 219: 294-305.
34. Monzani E, Facchetti F, Galmozzi E, Corsini E, Benetti A, Cavazzin C, Gritti A, Piccinini A, Porro D, Santinami M, Invernici G, Parati E, Alessandri G, La Porta CAM,. 2007. Melanoma contains CD133 and ABCG2 positive cells with enhanced tumorigenic potential. Eur J Cancer 43: 935-946.
35. Murphy JJ, Heptinstall S, Mitchell JR,. 1988. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet 2: 189-192.
36. Naugler WE, Karin M,. 2008. NF-κB and cancerâIdentifying targets and mechanisms. Curr Opin Genet Dev 18: 19-26.
37. Noble M, Smith J, Power J, Mayer-Proschel M,. 2003. Redox state as a central modulator of precursor cell function. Ann NY Acad Sci 991: 251-271.
38. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R,. 2007. Identification and expansion of human colon-cancer initiating cells. Nature 445 (7123): 111-115.
39. Siclari VA, Qin L,. 2010. Targeting the osteosarcoma cancer stem cell. J Orthop Surg Res 5: 78.
40. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB,. 2004. Identification of human brain tumour initiating cells. Nature 432 (7015): 396-401.
41. Sun Y, St. Clair DK, Xu Y, Crooks PA, St. Clair WH,. 2010. A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res 70: 2880-2890.
42. Szotek PP, Pieretti-Vanmarcke R, Masiakos PT, Dinulescu DM, Connoll D, Foster R, Dombrowski D, Preffer F, Maclaughlin DT, Donahoe PK,. 2006. Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness. Proc Natl Acad Sci USA 103: 11154-11159.
43. Tang C, Ang BT, Pervaiz S,. 2007. Cancer stem cell: Target for anti-cancer therapy. FASEB J 21: 3777-3785.
44. Tang N, Song WX, Luo J, Haydon RC, He TC,. 2008. Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res 466: 2114-2130.
45. Tirino V, Desiderio V, d'Aquino R, De Francesco F, Pirozzi G, Galderisi U, Cavaliere C, De Rosa A, Papaccio G,. 2008. Detection and characterization of CD133+ cancer stem cells in human solid tumours. PLoS ONE 3 (10): e3469.
46. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM,. 1996. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274 (5288): 787-789.
47. Vogelstein B, Lane D, Levine AJ,. 2000. Surfing the p53 network. Nature 408: 307-310.
48. Wen J, You KR, Lee SY, Song CH, Kim DG,. 2002. Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem 277: 38954-38964.
49. Yin S, Li J, Hu C, Chen X, Yao M, Yan M, Jiang G, Ge C, Xie H, Wan D, Yang S, Zheng S, Gu J,. 2007. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer 120: 1444-1450.
50. Zhang S, Ong CN, Shen HM,. 2004. Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett 208: 143-153.
51. Zhao Q, Wang C, Zhu J, Wang L, Dong S, Zhang G, Tian J,. 2011. RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion, and migration of SaOS2 human osteosarcoma cells: A case control study. J Exp Clin Cancer Res 30: 26.