Simukunin from the salivary glands of the black fly simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Tsujimoto, Hitoshi ^a,b,e   Kotsyfakis, Michail ^c   Francischetti, Ivo M B ^d   Eum, Jai Hoon ^a   Strand, Michael R ^a,b   Champagne, Donald E ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c INSTITUTE OF PARASITOLOGY   (Czech Republic)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 12A; BLOOD CLOTTING FACTOR 9A; CATHEPSIN G; ELASTASE; PLASMIN; SERINE PROTEINASE; SIMUKUNIN; SV 170; SV 66; THROMBIN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; INSECT PROTEIN; PANCREATIC ELASTASE; RECOMBINANT PROTEIN; SALIVA PROTEIN; SV 66 PROTEIN, SIMULIUM VITTATUM; SV-66 PROTEIN, SIMULIUM VITTATUM;

ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; HUMAN; IC 50; MALE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SALIVARY GLAND; SIMULIUM; SIMULIUM VITTATUM; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; INFLAMMATION; KINETICS; METABOLISM; MOLECULAR GENETICS; SIMULIIDAE;

DIPTERA; MAMMALIA; ONCHOCERCA VOLVULUS; SIMULIIDAE; SIMULIUM NIGRICOXUM; SIMULIUM VITTATUM;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOOD COAGULATION; CATALYTIC DOMAIN; CATHEPSIN G; DNA MUTATIONAL ANALYSIS; ENZYME INHIBITORS; FACTOR XA; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INFLAMMATION; INHIBITORY CONCENTRATION 50; INSECT PROTEINS; KINETICS; MALE; MOLECULAR SEQUENCE DATA; PANCREATIC ELASTASE; RECOMBINANT PROTEINS; SALIVARY GLANDS; SALIVARY PROTEINS AND PEPTIDES; SIMULIIDAE; SURFACE PLASMON RESONANCE;

EID: 84857551964     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029964     Document Type: Article

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