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Volumn 93, Issue 2, 1999, Pages 82-91

Savignin, a potent thrombin inhibitor isolated from the salivary glands of the tick Ornithodoros savignyi (Acari: Argasidae)

Author keywords

Activated factor X; Adenosine diphosphate; Anticoagulant; Electrospray mass spectrometry; High performance liquid chromatography; N benzoyl L arginine p nitroaniline; Ornithodoros savignyi; Salivary gland extracts; Savignin; Thrombin inhibitor; Ticks; Trifluoracetic acid

Indexed keywords

ADENOSINE DIPHOSPHATE; BLOOD CLOTTING FACTOR 10A; COLLAGEN; PLASMIN; SAVIGNIN; THROMBIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

EID: 0032887014     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1999.4448     Document Type: Article
Times cited : (86)

References (35)
  • 4
    • 78651139188 scopus 로고
    • The aggregation of blood platelets
    • Born G. V. R., Cross M. J. The aggregation of blood platelets. Journal of Physiology. 168:1963;178-195.
    • (1963) Journal of Physiology , vol.168 , pp. 178-195
    • Born, G.V.R.1    Cross, M.J.2
  • 5
    • 0001054571 scopus 로고
    • A simple modification converts the spinning cup protein sequencer into a vapour-phase sequencer
    • Brandt W. F., Alk H., Chauhan M., Von Holt C. A simple modification converts the spinning cup protein sequencer into a vapour-phase sequencer. FEBS Letters. 174:1984;228-232.
    • (1984) FEBS Letters , vol.174 , pp. 228-232
    • Brandt, W.F.1    Alk, H.2    Chauhan, M.3    Von Holt, C.4
  • 6
  • 7
    • 33644864110 scopus 로고
    • P-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin
    • Chase T., Shaw E. p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin. Biochemical and Biophysical Research Communications. 29:1967;508-514.
    • (1967) Biochemical and Biophysical Research Communications , vol.29 , pp. 508-514
    • Chase, T.1    Shaw, E.2
  • 10
    • 0029248203 scopus 로고
    • Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi
    • Gaspar A. R. M. D., Crause J. C., Neitz A. W. H. Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi. Experimental and Applied Acarology. 19:1995;117-126.
    • (1995) Experimental and Applied Acarology , vol.19 , pp. 117-126
    • Gaspar, A.R.M.D.1    Crause, J.C.2    Neitz, A.W.H.3
  • 11
    • 0030267778 scopus 로고    scopus 로고
    • Isolation and characterization of an anticoagulant from the salivary glands of the tick, Ornithodoros savignyi (Acari: Argasidae)
    • Gaspar A. R. M. D., Joubert A. M., Crause J. C., Neitz A. W. H. Isolation and characterization of an anticoagulant from the salivary glands of the tick, Ornithodoros savignyi (Acari: Argasidae). Experimental and Applied Acarology. 20:1996;583-598.
    • (1996) Experimental and Applied Acarology , vol.20 , pp. 583-598
    • Gaspar, A.R.M.D.1    Joubert, A.M.2    Crause, J.C.3    Neitz, A.W.H.4
  • 14
    • 0028020715 scopus 로고
    • Amino acid analysis and protein database composition search as a fast and inexpensive method to identify proteins
    • Hobohm U., Houthaeve T., Sander C. Amino acid analysis and protein database composition search as a fast and inexpensive method to identify proteins. Analytical Biochemistry. 222:1994;202.
    • (1994) Analytical Biochemistry , vol.222 , pp. 202
    • Hobohm, U.1    Houthaeve, T.2    Sander, C.3
  • 15
    • 0032192297 scopus 로고    scopus 로고
    • Cloning, nucleotide sequence and expression of the gene encoding factor Xa inhibitor from the salivary glands of the tick, Ornithodoros savignyi
    • Joubert A. M., Louw A. I., Joubert F., Neitz A. W. H. Cloning, nucleotide sequence and expression of the gene encoding factor Xa inhibitor from the salivary glands of the tick, Ornithodoros savignyi. Experimental and Applied Acarology. 22:1998;1-17.
    • (1998) Experimental and Applied Acarology , vol.22 , pp. 1-17
    • Joubert, A.M.1    Louw, A.I.2    Joubert, F.3    Neitz, A.W.H.4
  • 16
    • 0028217639 scopus 로고
    • Disagregin is a fibrinogen receptor antagonist lacking the Arg-Gly-Asp sequence from the tick, Ornithodoros moubata
    • Karczewski J., Endris R. G., Connolly T. M. Disagregin is a fibrinogen receptor antagonist lacking the Arg-Gly-Asp sequence from the tick, Ornithodoros moubata. Journal of Biological Chemistry. 269:1994;6702-6708.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 6702-6708
    • Karczewski, J.1    Endris, R.G.2    Connolly, T.M.3
  • 18
    • 0344696362 scopus 로고    scopus 로고
    • Identification and partial isolation of a fibrinogenolytic activity in the salivary glands of the tick, Ornithodoros savignyi. Biochemistry in Africa
    • Mahlaku M. M., Gaspar A. R. M., Neitz A. W. H. Identification and partial isolation of a fibrinogenolytic activity in the salivary glands of the tick, Ornithodoros savignyi. Biochemistry in Africa. South African Society of Biochemistry and Molecular Biology. 1998.
    • (1998) South African Society of Biochemistry and Molecular Biology
    • Mahlaku, M.M.1    Gaspar, A.R.M.2    Neitz, A.W.H.3
  • 19
    • 0032103190 scopus 로고    scopus 로고
    • Apyrase activity and platelet aggregation inhibitors in the tick Ornithodoros savignyi (Acari:Argasidae)
    • Mans B. J., Gaspar A. R. M. D., Louw A. I., Neitz A. W. H. Apyrase activity and platelet aggregation inhibitors in the tick Ornithodoros savignyi (Acari:Argasidae). Experimental and Applied Acarology. 22:1998a;353-366.
    • (1998) Experimental and Applied Acarology , vol.22 , pp. 353-366
    • Mans, B.J.1    Gaspar, A.R.M.D.2    Louw, A.I.3    Neitz, A.W.H.4
  • 21
    • 0000319455 scopus 로고
    • Hirudin as an inhibitor of thrombin
    • Markwardt F. Hirudin as an inhibitor of thrombin. Methods in Enzymology. 19:1970;924-932.
    • (1970) Methods in Enzymology , vol.19 , pp. 924-932
    • Markwardt, F.1
  • 22
    • 0014454095 scopus 로고
    • Kinetics of the reversible inhibition of enzyme-catalyzed reactions by tight-binding inhibitors
    • Morrison J. F. Kinetics of the reversible inhibition of enzyme-catalyzed reactions by tight-binding inhibitors. Biochimica et Biophysica Acta. 185:1969;269-286.
    • (1969) Biochimica et Biophysica Acta , vol.185 , pp. 269-286
    • Morrison, J.F.1
  • 25
    • 0022521744 scopus 로고
    • Kinetics of the inhibition of thrombin by hirudin
    • Stone S. R., Hofsteenge J. Kinetics of the inhibition of thrombin by hirudin. Biochemistry. 25:1986;4622-4628.
    • (1986) Biochemistry , vol.25 , pp. 4622-4628
    • Stone, S.R.1    Hofsteenge, J.2
  • 26
    • 0025821642 scopus 로고
    • Basis for the reduced affinity of βτ and γτthrombin for hirudin
    • Stone S. R., Hofsteenge J. Basis for the reduced affinity of βτ and γτthrombin for hirudin. Biochemistry. 30:1991;3950-3955.
    • (1991) Biochemistry , vol.30 , pp. 3950-3955
    • Stone, S.R.1    Hofsteenge, J.2
  • 28
    • 0027409404 scopus 로고
    • A player of many parts: The spotlight falls on thrombin's structure
    • Stubbs M. T., Bode W. A player of many parts: The spotlight falls on thrombin's structure. Thrombosis Research. 69:1993;1-58.
    • (1993) Thrombosis Research , vol.69 , pp. 1-58
    • Stubbs, M.T.1    Bode, W.2
  • 29
    • 0028912561 scopus 로고
    • The clot thickens: Clues provided by thrombin structure
    • Stubbs M. T., Bode W. The clot thickens: Clues provided by thrombin structure. Trends in Biochemical Science. 20:1995;23-28.
    • (1995) Trends in Biochemical Science , vol.20 , pp. 23-28
    • Stubbs, M.T.1    Bode, W.2
  • 30
    • 0028784163 scopus 로고
    • Two heads are better than one: Crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin
    • Van De Locht A., Lamba D., Bauer M., Huber R., Friedrich T., Kröger B., Höffken W., Bode W. Two heads are better than one: Crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. The EMBO Journal. 14:1995;5149-5157.
    • (1995) The EMBO Journal , vol.14 , pp. 5149-5157
    • Van De Locht, A.1    Lamba, D.2    Bauer, M.3    Huber, R.4    Friedrich, T.5    Kröger, B.6    Höffken, W.7    Bode, W.8
  • 32
    • 0025375504 scopus 로고
    • Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa
    • Waxman L., Smith D. E., Arcuri K. E., Vlasuk G. P. Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa. Science. 248:1990;593-596.
    • (1990) Science , vol.248 , pp. 593-596
    • Waxman, L.1    Smith, D.E.2    Arcuri, K.E.3    Vlasuk, G.P.4
  • 34
    • 0018699952 scopus 로고
    • The kinetics of reversible tight-binding inhibition
    • Williams J. W., Morrison J. F. The kinetics of reversible tight-binding inhibition. Methods in Enzymology. 63:1979;437-467.
    • (1979) Methods in Enzymology , vol.63 , pp. 437-467
    • Williams, J.W.1    Morrison, J.F.2
  • 35
    • 0031238807 scopus 로고    scopus 로고
    • Isolation and characterization of americanin, a specific inhibitor of thrombin, from the salivary glands of the lone star tick Amblyomma americanum (L.)
    • Zhu K., Bowman A. S., Brigham D. L., Essenberg R. C., Dillwith J. W., Sauer J. R. Isolation and characterization of americanin, a specific inhibitor of thrombin, from the salivary glands of the lone star tick Amblyomma americanum (L.). Experimental Parasitology. 87:1997;30-38.
    • (1997) Experimental Parasitology , vol.87 , pp. 30-38
    • Zhu, K.1    Bowman, A.S.2    Brigham, D.L.3    Essenberg, R.C.4    Dillwith, J.W.5    Sauer, J.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.