Oxygen levels epigenetically regulate fate switching of neural precursor cells via hypoxia-inducible factor 1α-Notch signal interaction in the developing brain

Stem Cells

Volumn 30, Issue 3, 2012, Pages 561-569

  Mutoh, Tetsuji ^a   Sanosaka, Tsukasa ^a   Ito, Kei ^a   Nakashima, Kinichi ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Astrocyte differentiation; DNA methylation; Epigenetic gene regulation; Neural precursor cell; Notch signaling; Oxygen concentration

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL FATE; DEMETHYLATION; GESTATION PERIOD; HYPOXIA; MOUSE; NEURAL STEM CELL; NONHUMAN; OXYGEN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ASTROCYTES; BRAIN; CELL DIFFERENTIATION; CELL HYPOXIA; CELLS, CULTURED; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUKEMIA INHIBITORY FACTOR; MICE; MICE, INBRED ICR; NEURAL STEM CELLS; OXYGEN; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84857498375     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1019     Document Type: Article

References (40)

1. Hirabayashi Y, Gotoh Y. Epigenetic control of neural precursor cell fate during development. Nat Rev Neurosci 2010;11:377-388.
2. Bonni A, Sun Y, Nadal-Vicens M et al. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 1997;278:477-483. (Pubitemid 27454434)
3. Nakashima K, Wiese S, Yanagisawa M et al. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. J Neurosci 1999;19:5429-5434. (Pubitemid 29300208)
4. Fan G, Martinowich K, Chin MH et al. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development 2005;132:3345-3356. (Pubitemid 41246111)
5. Takizawa T, Nakashima K, Namihira M et al. DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 2001;1:749-758. (Pubitemid 33586130)
6. Pierfelice T, Alberi L, Gaiano N. Notch in the vertebrate nervous system: An old dog with new tricks. Neuron 2011;69:840-855.
7. Namihira M, Kohyama J, Semi K et al. Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell 2009;16:245-255.
8. Slater TF. Free-radical mechanisms in tissue injury. Biochem J. 1984; 222:1-15.
9. Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-1340. (Pubitemid 33063099)
10. Sang N, Fang J, Srinivas V et al. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel- Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Mol Cell Biol 2002;22:2984-2992. (Pubitemid 34437457)
11. Simon MC, Keith B. The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 2008;9: 285-296. (Pubitemid 351430845)
12. Lofstedt T, Jogi A, Sigvardsson M et al. Induction of ID2 expression by hypoxia-inducible factor-1: A role in dedifferentiation of hypoxic neuroblastoma cells. J Biol Chem 2004;279:39223-39231. (Pubitemid 39258183)
13. Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002;64:993-998. (Pubitemid 35232274)
14. Tomita S, Ueno M, Sakamoto M et al. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol 2003;23:6739-6749. (Pubitemid 37214645)
15. Gustafsson MV, Zheng X, Pereira T et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005;9: 617-628. (Pubitemid 41555144)
16. Dunlop EA, Tee AR. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cell Signal 2009; 21:827-835.
17. Land SC, Tee AR. Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem 2007;282:20534-20543. (Pubitemid 47100043)
18. Jogi A, Ora I, Nilsson H et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci USA 2002;99:7021-7026. (Pubitemid 34526250)
19. Chen HL, Pistollato F, Hoeppner DJ et al. Oxygen tension regulates survival and fate of mouse central nervous system precursors at multiple levels. Stem Cells 2007;25:2291-2301. (Pubitemid 47480488)
20. Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A. Oxygen in stem cell biology: A critical component of the stem cell niche. Cell Stem Cell 2010;7:150-161.
21. Wright WE, Shay JW. Inexpensive low-oxygen incubators. Nat Protoc 2006;1:2088-2090. (Pubitemid 46773331)
22. Moeller BJ, Dreher MR, Rabbani ZN et al. Pleiotropic effects of HIF- 1 blockade on tumor radiosensitivity. Cancer Cell 2005;8:99-110. (Pubitemid 41132739)
23. Zhou Z, Hong EJ, Cohen S et al. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 2006;52:255-269. (Pubitemid 44548348)
24. Lois-Caballe C, BaItimore D, Qin X-F. Method for expression of small antiviral RNA molecules within a cell. US Patent0 059 944 Al. 2003.
25. Mutoh T, Miyata T, Kashiwagi S et al. Dynamic behavior of individual cells in developing organotypic brain slices revealed by the photoconvertable protein Kaede. Exp Neurol 2006;200:430-437. (Pubitemid 44107922)
26. Papkovskii DB, Yaropolov AI, Savitskii AP et al. Fibre-optic oxygen sensor based on phosphorescence quenching. Biomed Sci 1991;2: 536-539.
27. Hatada I, Namihira M, Morita S et al. Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation. PLoS One 2008;3:e3189.
28. Dunwoodie SL. The role of hypoxia in development of the Mammalian embryo. Dev Cell 2009;17:755-773.
29. Arteel GE, Thurman RG, Raleigh JA. Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur J Biochem 1998; 253:743-750. (Pubitemid 28223543)
30. Raleigh JA, La Dine JK, Cline JM et al. An enzyme-linked immunosorbent assay for hypoxia marker binding in tumours. Br J Cancer 1994;69:66-71. (Pubitemid 24021824)
31. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998;12:149-162.
32. Jain S, Maltepe E, Lu MM et al. Expression of ARNT, ARNT2, HIF1 Alpha, HIF2 alpha and Ah receptor Mrnas in the developing mouse. Mech Dev 1998;73:117-123. (Pubitemid 28218548)
33. Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol Cell 2008;30:393-402. (Pubitemid 351681994)
34. Palmer LA, Semenza GL, Stoler MH et al. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol 1998;274:L212-L219.
35. Roitbak T, Surviladze Z, Cunningham LA. Continuous expression of HIF-1alpha in neural stem/progenitor cells. Cell Mol Neurobiol 2011; 31:119-133.
36. Hirsila M, Koivunen P, Gunzler V et al. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 2003;278:30772-30780. (Pubitemid 36994584)
37. Martinez R, Esteller M. The DNA methylome of glioblastoma multiforme. Neurobiol Dis 2011;39:40-46.
38. Quinn GE, Dobson V. Outcome of prematurity and retinopathy of prematurity. Curr Opin Ophthalmol 1996;7:51-56. (Pubitemid 26321778)
39. Blackburn S. Environmental impact of the NICU on developmental outcomes. J Pediatr Nurs 1998;13:279-289.
40. Deulofeut R, Critz A, Adams-Chapman I et al. Avoiding hyperoxia in infants < or = 1250 g is associated with improved short- and longterm outcomes. J Perinatol 2006;26:700-705. (Pubitemid 44650189)