In vitro expansion of human γδ and CD56 + T-cells by Aspergillus-antigen loaded fast dendritic cells in the presence of exogenous interleukin-12

Immunopharmacology and Immunotoxicology

Volumn 34, Issue 2, 2012, Pages 309-316

  Ramadan, Gamal ^a,b  

^a KING FAISAL UNIVERSITY   (Saudi Arabia)

^b Ain Shams University   (Egypt)

Author keywords

Aspergillus fumigatus; Dendritic cells; IL 12; Innate immunity; Lymphocytes

Indexed keywords

ASPERGILLUS FUMIGATUS ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; FUNGUS ANTIGEN; INTERLEUKIN 12; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FUMIGATUS; CD56+ T LYMPHOCYTE; CELL EXPANSION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; GAMMA DELTA T LYMPHOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD56; ANTIGENS, FUNGAL; ASPERGILLUS FUMIGATUS; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; DENDRITIC CELLS; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-12; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

ASPERGILLUS; ASPERGILLUS FUMIGATUS;

EID: 84857490570     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2011.603339     Document Type: Article

References (39)

1. Falini, B., Flenghi, L., Pileri, S., Pelicci, P., Fagioli, M., Martelli, M.F., Moretta, L., Ciccone, E. Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues. J Immunol 1989, 143, 2480-2488. (Pubitemid 19260052)
2. Knight, A., Madrigal, A.J., Grace, S., Sivakumaran, J., Kottaridis, P., Mackinnon, S., Travers, P.J., Lowdell, M.W. The role of Vd2-negative ?d T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation. Blood 2010, 116, 2164-2172.
3. Lopez, R.D. Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases. Immunol Res 2002, 26, 207-221. (Pubitemid 35177498)
4. Wallace, M., Bartz, S.R., Chang, W.L., Mackenzie, D.A., Pauza, C.D., Malkovsky, M. Gamma delta T lymphocyte responses to HIV. Clin Exp Immunol 1996, 103, 177-184.
5. Boismenu, R., Havran, W.L. Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science 1994, 266, 1253-1255. (Pubitemid 24371285)
6. Kawanishi, Y., Passweg, J., Drobyski, W.R., Rowlings, P., Cook- Craig, A., Casper, J., Pietryga, D., Garbrecht, F., Camitta, B., Horowitz, M., Juckett, M., Margolis, D., Flomenberg, N., Keever- Taylor, C.A. Effect of T cell subset dose on outcome of T celldepleted bone marrow transplantation. Bone Marrow Transplant 1997, 19, 1069-1077. (Pubitemid 27267729)
7. Ericsson, P.O., Hansson, J., Widegren, B., Dohlsten, M., Sjögren, H.O., Hedlund, G. In vivo induction of gamma/delta T cells with highly potent and selective anti-tumor cytotoxicity. Eur J Immunol 1991, 21, 2797-2802.
8. Fisch, P., Malkovsky, M., Kovats, S., Sturm, E., Braakman, E., Klein, B.S., Voss, S.D., Morrissey, L.W., DeMars, R., Welch, W.J. Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science 1990, 250, 1269-1273. (Pubitemid 120031842)
9. Girardi, M., Oppenheim, D.E., Steele, C.R., Lewis, J.M., Glusac, E., Filler, R., Hobby, P., Sutton, B., Tigelaar, R.E., Hayday, A.C. Regulation of cutaneous malignancy by gammadelta T cells. Science 2001, 294, 605-609. (Pubitemid 32999559)
10. Kaminski, M.J., Cruz, P.D. Jr, Bergstresser, P.R., Takashima, A. Killing of skin-derived tumor cells by mouse dendritic epidermal T-cells. Cancer Res 1993, 53, 4014-4019. (Pubitemid 23267704)
11. Nanno, M., Seki, H., Mathioudakis, G., Suzuki, R., Itoh, K., Ioannides, C.G., Suzuki, S., Chen, P.F., Platsoucas, C.D. Gamma/delta T cell antigen receptors expressed on tumor-infiltrating lymphocytes from patients with solid tumors. Eur J Immunol 1992, 22, 679-687.
12. Alexander, A.A., Maniar, A., Cummings, J.S., Hebbeler, A.M., Schulze, D.H., Gastman, B.R., Pauza, C.D., Strome, S.E., Chapoval, A.I. Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. Clin Cancer Res 2008, 14, 4232-4240.
13. Janssen, O., Wesselborg, S., Heckl-Ostreicher, B., Pechhold, K., Bender, A., Schondelmaier, S., Moldenhauer, G., Kabelitz, D. T cell receptor/CD3- signaling induces death by apoptosis in human T cell receptor gamma delta + T cells. J Immunol 1991, 146, 35-39.
14. Lopez, R.D., Xu, S., Guo, B., Negrin, R.S., Waller, E.K. CD2- mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the largescale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies. Blood 2000, 96, 3827-3837.
15. Steinman, R.M. Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system. Nat Med 2007, 13, 1155-1159.
16. Gruenbacher, G., Gander, H., Rahm, A., Nussbaumer, W., Romani, N., Thurnher, M. CD56+ human blood dendritic cells effectively promote TH1-type gammadelta T-cell responses. Blood 2009, 114, 4422-4431.
17. Münz, C., Steinman, R.M., Fujii, S. Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity. J Exp Med 2005, 202, 203-207. (Pubitemid 41043815)
18. Meraviglia, S., Caccamo, N., Salerno, A., Sireci, G., Dieli, F. Partial and ineffective activation of V gamma 9V delta 2 T cells by Mycobacterium tuberculosis-infected dendritic cells. J Immunol 2010, 185, 1770-1776.
19. Marr, K.A., Patterson, T., Denning, D. Aspergillosis. Pathogenesis, clinical manifestations, and therapy. Infect Dis Clin North Am 2002, 16, 875-94, vi.
20. Hebart, H., Bollinger, C., Fisch, P., Sarfati, J., Meisner, C., Baur, M., Loeffler, J., Monod, M., Latgé, J.P., Einsele, H. Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies. Blood 2002, 100, 4521-4528. (Pubitemid 35429693)
21. Denning, D.W. Invasive aspergillosis. Clin Infect Dis 1998, 26, 781- 803; quiz 804.
22. Ramadan, G. The proliferative response of T cells to Aspergillus antigen requires prior presentation on dendritic cells. Egypt J Immunol 2004, 11, 47-58.
23. Ramadan, G. Generation of Aspergillus-specific T lymphocytes with cytotoxic activity. Egypt J Immunol 2004, 11, 59-70.
24. Emtage, P.C., Clarke, D., Gonzalo-Daganzo, R., Junghans, R.P., Gonzalo-Dagonzo, R. Generating potent Th1/Tc1 T cell adoptive immunotherapy doses using human IL-12: Harnessing the immunomodulatory potential of IL-12 without the in vivoassociated toxicity. J Immunother 2003, 26, 97-106. (Pubitemid 36292780)
25. Xu, S., Koski, G.K., Faries, M., Bedrosian, I., Mick, R., Maeurer, M., Cheever, M.A., Cohen, P.A., Czerniecki, B.J. Rapid high efficiency sensitization of CD8+ T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism. J Immunol 2003, 171, 2251-2261. (Pubitemid 37025530)
26. Ramadan, G., Konings, S., Kurup, V.P., Keever-Taylor, C.A. Generation of Aspergillus- And CMV- specific T-cell responses using autologous fast DC. Cytotherapy 2004, 6, 223-234. (Pubitemid 38868095)
27. Ramadan, G. Epstein-Barr virus-transformed B-cells as efficient antigen presenting cells to propagate Aspergillus-specific cytotoxic T-lymphocytes. Egypt J Immunol 2008, 15, 145-157.
28. Kurup, V.P., Xia, J.Q., Rickaby, D.A., Dawson, C.A., Choi, H., Fink, J.N. Aspergillus fumigatus antigen exposure results in pulmonaryairway resistance in wild-type but not in IL-4 knockout mice. Clin Immunol 1999, 90, 404-410. (Pubitemid 29159626)
29. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J.H., Lanier, L.L., Spies, T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999, 285, 727-729.
30. Griffith, E., Ramsburg, E., Hayday, A. Recognition by human gut gamma delta cells of stress inducible major histocompatibility molecules on enterocytes. Gut 1998, 43, 166-167. (Pubitemid 28348315)
31. Steinle, A., Groh, V., Spies, T. Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules. Proc Natl Acad Sci USA 1998, 95, 12510-12515.
32. Kurup, V.P., Grunig, G. Animal models of allergic bronchopulmonary aspergillosis. Mycopathologia 2002, 153, 165-177. (Pubitemid 34394926)
33. Guo, B.L., Hollmig, K.A., Lopez, R.D. Down-regulation of IL-2 receptor alpha (CD25) characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12. Cancer Immunol Immunother 2002, 50, 625-637. (Pubitemid 34045262)
34. Grabstein, K.H., Eisenman, J., Shanebeck, K., Rauch, C., Srinivasan, S., Fung, V., Beers, C., Richardson, J., Schoenborn, M.A., Ahdieh, M. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994, 264, 965-968. (Pubitemid 24196167)
35. Mattei, F., Schiavoni, G., Belardelli, F., Tough, D.F. IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J Immunol 2001, 167, 1179-1187. (Pubitemid 32703111)
36. Pullarkat, V., Lau, R., Lee, S.M., Bender, J.G., Weber, J.S. Large-scale monocyte enrichment coupled with a closed culture system for the generation of human dendritic cells. J Immunol Methods 2002, 267, 173-183. (Pubitemid 34880032)
37. Braedel, S., Radsak, M., Einsele, H., Latgé, J.P., Michan, A., Loeffler, J., Haddad, Z., Grigoleit, U., Schild, H., Hebart, H. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol 2004, 125, 392-399. (Pubitemid 38621772)
38. Young, M.R. Protective mechanisms of head and neck squamous cell carcinomas from immune assault. Head Neck 2006, 28, 462-470. (Pubitemid 43673082)
39. Verneris, M.R., Kornacker, M., Mailänder, V., Negrin, R.S. Resistance of ex vivo expanded CD3+CD56+ T cells to Fas-mediated apoptosis. Cancer Immunol Immunother 2000, 49, 335-345. (Pubitemid 30615048)