Generation of tumour-necrosis-factor-α-specific affibody1 molecules capable of blocking receptor binding in vitro

Biotechnology and Applied Biochemistry

Volumn 54, Issue 2, 2009, Pages 93-103

  Jonsson, Andreas ^a,b   Wållberg, Helena ^a   Herne, Nina ^c   Ståhl, Stefan ^a   Frejd, Fredrik Y ^b,d  

^a ALBANOVA UNIVERSITY CENTER   (Sweden)

^b Affibody AB   (Sweden)

^c NeuroNova AB   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Affibody molecule; Albumin binding domain based affibody screening ELISA (ABAS ELISA); Biospecific interaction analysis (BIA); Immobilized metal ion affinity chromatography (IMAC); Phage display; Tumour necrosis factor (TNF )

Indexed keywords

AFFIBODY MOLECULE; ALBUMIN-BINDING-DOMAIN-BASED AFFIBODY-SCREENING ELISA (ABAS ELISA); BIOSPECIFIC INTERACTION ANALYSIS (BIA); IMMOBILIZED-METAL-ION AFFINITY CHROMATOGRAPHY (IMAC); PHAGE DISPLAY;

AFFINITY CHROMATOGRAPHY; BINDING ENERGY; BIOSENSORS; CHROMATOGRAPHIC ANALYSIS; CLUSTER ANALYSIS; DIAGNOSIS; DRUG PRODUCTS; ESCHERICHIA COLI; GLYCOPROTEINS; ION CHROMATOGRAPHY; IONS; MACROPHAGES; METAL ANALYSIS; METAL REFINING; MOLECULES; OLIGOMERS; TUMORS;

BINDING SITES;

DIMER; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

AFFIBODY MOLECULE; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOSENSOR; GENE CLUSTER; GENE CONSTRUCT; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; IN VITRO STUDY; INFLAMMATION; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; BIOSENSING TECHNIQUES; CLUSTER ANALYSIS; ESCHERICHIA COLI; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; SWINE; TUMOR NECROSIS FACTOR-ALPHA;

ESCHERICHIA COLI; PSIDIUM GUAJAVA; RATTUS; SUIDAE;

EID: 70350521639     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20090085     Document Type: Article

References (24)

1. Wallis, R. S. (2008) Lancet Infect. Dis. 8, 601-611
2. Tobin, A. M. and Kirby, B. (2005) BioDrugs 19, 47-57
3. Stokkers, P. C. and Hommes, D. W. (2004) Cytokine 28, 167-173
4. Van den Bosch, F., Kruithof, E., De Vos, M., De Keyser, F. and Mielants, H. (2000) Lancet 356, 1821-1822
5. Bourne, T., Fossati, G. and Nesbitt, A. (2008) BioDrugs 22, 331-337
6. Kaymakcalan, Z., Sakorafas, P., Bose, S., Scesney, S., Xiong, L., Hanzatian, D. K., Salfeld, J. and Sasso, E. H. (2009) Clin. Immunol. 131, 308-316
7. Tracey, D., Klareskog, L., Sasso, E. H., Salfeld, J. G. and Tak, P. P. (2008) Pharmacol. Ther. 117, 244-279
8. Bombardieri, S., Ruiz, A. A., Fardellone, P., Geusens, P., McKenna, F., Unnebrink, K., Oezer, U., Kary, S., Kupper, H. and Burmester, G. R. (2007) Rheumatology 46, 1191-1199
9. Franquet, T. and Stern, E. J. (1999) Eur. Radiol. 9, 1290-1303
10. Bleeker-Rovers, C. P., Boerman,O. C., Rennen, H. J., Corstens, F. H. and Oyen, W. J. (2004) Curr. Pharm. Des. 10, 2935-2950
11. Tehranzadeh, J., Ashikyan, O. and Dascalos, J. (2003) Semin. Musculoskelet. Radiol. 7, 79-94
12. Cao, Q., Cai, W., Li, Z. B., Chen, K., He, L., Li, H. C., Hui, M. and Chen, X. (2007) Eur. J. Nucl. Med. Mol. Imaging 34, 1832-1842
13. Coppieters, K., Dreier, T., Silence, K., de Haard, H., Lauwereys, M., Casteels, P., Beirnaert, E., Jonckheere, H., Van de Wiele, C., Staelens, L. et al. (2006) Arthritis Rheum. 54, 1856-1866
14. Nilsson, B., Moks, T., Jansson, B., Abrahmsen, L., Elmblad, A., Holmgren, E., Henrichson, C., Jones, T. A. and Uhlen, M. (1987) Protein Eng. 1, 107-113
15. Nord, K., Gunneriusson, E., Ringdahl, J., Stahl, S., Uhlen, M. and Nygren, P. A. (1997) Nat. Biotechnol. 15, 772-777
16. Nygren, P. A. (2008) FEBS J. 275, 2668-2676
17. Orlova, A., Magnusson, M., Eriksson, T. L., Nilsson, M., Larsson, B., Hoiden-Guthenberg, I., Widstrom, C., Carlsson, J., Tolmachev, V., Stahl, S. and Nilsson, F. Y. (2006) Cancer Res. 66, 4339-4348
18. Friedman, M., Orlova, A., Johansson, E., Eriksson, T. L., Hoiden-Guthenberg, I., Tolmachev, V., Nilsson, F. Y. and Stahl, S. (2008) J. Mol. Biol. 376, 1388-1402
19. Nilsson, F. Y. and Tolmachev, V. (2007) Curr. Opin. Drug Discov. Dev. 10, 167-175
20. Baum, R. P., Orlova, A., Tolmachev, V. and Feldwisch, J. (2006) Eur. J. Nucl. Med. Mol. Imaging 33, S91
21. Grönwall, C., Jonsson, A., Lindstrom, S., Gunneriusson, E., Stahl, S. and Herne, N. (2007) J. Biotechnol. 128, 162-183
22. Studier, F. W., Rosenberg, A. H., Dunn, J. J. and Dubendorff, J. W. (1990) Methods Enzymol. 185, 60-89
23. a Moreland, L. W., Baumgartner, S. W., Schiff, M. H., Tindall, E. A., Fleischmann, R. M.,Weaver, A. L., Ettlinger, R. E., Cohen, S., Koopman, W. J. Mohler, K. et al. (1997) N. Engl. J. Med. 337, 141-147
24. Kronqvist, N., Lofblom, J., Jonsson, A.,Wernerus, H. and Stahl, S. (2008) Protein Eng. Des. Sel. 21, 247-255