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Volumn 285, Issue 16, 2010, Pages 12096-12100
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Selection of a novel and highly specific tumor necrosis factor α (TNFα) antagonist: Insight from the crystal structure of the antagonist-TNFα complex
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Author keywords
[No Author keywords available]
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Indexed keywords
BINDING AFFINITIES;
C-TYPE LECTINS;
CROHN DISEASE;
DOMAIN STRUCTURE;
INHIBITORY PROTEINS;
MOLECULAR LEVELS;
NEW TECHNOLOGIES;
PROTEIN THERAPEUTICS;
RHEUMATOID ARTHRITIS;
SELECTION PROCEDURES;
SPECIFIC CONTACT;
TECHNOLOGY PLATFORMS;
THERAPEUTIC PROTEIN;
THREE-DIMENSIONAL STRUCTURE;
TUMOR NECROSIS FACTORS;
BINDING ENERGY;
GLYCOPROTEINS;
LIGANDS;
MACROPHAGES;
PROTEINS;
TUMORS;
X RAY CRYSTALLOGRAPHY;
CRYSTAL STRUCTURE;
LECTIN;
TUMOR NECROSIS FACTOR ALPHA;
TUMOR NECROSIS FACTOR ALPHA INHIBITOR;
ANIMAL CELL;
APOPTOSIS;
ARTICLE;
BINDING AFFINITY;
BINDING KINETICS;
CELL STRAIN L 929;
COMPLEX FORMATION;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
DRUG MECHANISM;
IN VITRO STUDY;
MOUSE;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN BINDING;
PROTEIN DOMAIN;
PROTEIN STRUCTURE;
X RAY CRYSTALLOGRAPHY;
AMINO ACID SEQUENCE;
ANIMALS;
APOPTOSIS;
CELL LINE;
CRYSTALLOGRAPHY, X-RAY;
HUMANS;
LECTINS, C-TYPE;
MICE;
MODELS, MOLECULAR;
MOLECULAR SEQUENCE DATA;
MULTIPROTEIN COMPLEXES;
PEPTIDE LIBRARY;
PROTEIN STRUCTURE, QUATERNARY;
PROTEIN STRUCTURE, TERTIARY;
RECOMBINANT PROTEINS;
SURFACE PLASMON RESONANCE;
TUMOR NECROSIS FACTOR-ALPHA;
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EID: 77951233065
PISSN: 00219258
EISSN: 1083351X
Source Type: Journal
DOI: 10.1074/jbc.M109.063305 Document Type: Article |
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Times cited : (17)
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References (19)
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