T helper and B cell escape mutations within the HBc gene in patients with asymptomatic HBV infection: A study from the south-eastern region of Iran

Clinical Laboratory

Volumn 58, Issue 1-2, 2012, Pages 53-60

  Assar, Shokrollah ^a   Arababadi, Mohammad Kazemi ^a   Mohit, Maryam ^b   Ahmadabadi, Behzad Nasiri ^c   Pumpens, Paul ^d   Khorramdelazad, Hossein ^a   Hajghani, Masomeh ^b   Assar, Sepideh ^a   Araste, Majid ^e   Nekhei, Zohre ^e   Sendi, Hossein ^f,g   Kennedy, Derek ^h  

^a RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^e KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^g CAROLINAS MEDICAL CENTER   (United States)

^h GRIFFITH UNIVERSITY   (Australia)

Author keywords

Asymptomatic HBV infection; HBcAg; HLA A2; Mutation

Indexed keywords

EPITOPE; HEMOGLOBIN C;

ANTIGEN PRESENTATION; ARTICLE; ASYMPTOMATIC INFECTION; B LYMPHOCYTE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA EXTRACTION; DNA SEQUENCE; FLOW CYTOMETRY; GENE MUTATION; GENETIC ASSOCIATION; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IRAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

ADULT; AMINO ACID SEQUENCE; ANTIBODIES, VIRAL; ASYMPTOMATIC INFECTIONS; B-LYMPHOCYTES; BASE SEQUENCE; CENTRAL TOLERANCE; DNA, VIRAL; FEMALE; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HOST-PATHOGEN INTERACTIONS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84857423097     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Alavian SM, Fallahian F, Lankarani KB. The changing epidemiology of viral hepatitis B in Iran. J Gastrointestin Liver Dis 2007;16(4):403-6.
2. Amini-Bavil-Olyaee S, Sarrami-Forooshani R, Mahboudi F, et al. Genotype characterization and phylogenetic analysis of hepatitis B virus isolates from Iranian patients. J Med Virol 2005;75(2):227-34. (Pubitemid 40053733)
3. Eftekhari Y, Kazemi Arababadi M, Hakimi H, Rezazadeh Zarandi E. Common HBV genotype in southeastern Iranian patients. Arch Iran Med.2010;13(2):147-9.
4. Mansour-Ghanaei F, Rafiei R, Joukar F, et al. Relationship between serum HBV DNA level and liver histology in HBV carriers with normal ALT in Guilan province, Iran. Med Sci Monit 2010;16(3):BR97-101.
5. Mendy ME, Welzel T, Lesi OA, et al. Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa. J Viral Hepat 2009;27:27.
6. Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G, Rezvani ME. Association of exon 9 but not intron 8 VDR polymorphisms with occult HBV infection in south-eastern Iranian patients. J Gastroenterol Hepatol 2009;25(1):90-3.
7. Lacombe K, Boyd A, Gozlan J, Lavocat F, Girard PM, Zoulim F. Drug-resistant and immune-escape HBV mutants in HIV-infected hosts. Antivir Ther 2010;15(3 Pt B):493-7.
8. Liu HG, Chen WW, Fan ZP, et al. The high prevalence of the 127 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope. Clin Immunol 2007;125(3):337-45.
9. Sendi H, Mehrab-Mohseni M, Shahraz S, et al. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA. J Clin Virol 2009;46(3):259-64.
10. Arababadi MK, Hassanshahi G, Yousefi H. HBV-DNA in hemodialysis patients infected by HCV. Saudi J Kidney Dis Transpl 2009;20(3):398401.
11. Bates PA, Kelley LA, MacCallum RM, Sternberg MJ. Enhancement of protein modeling by human intervention in applying the automatic programs 3D-JIGSAW and 3D-PSSM. Proteins 2001;Suppl 5:39-46. (Pubitemid 34113166)
12. Pettersen EF, Goddard TD, Huang CC, et al. UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 2004;25(13):1605-12.
13. Sallberg M, Pushko P, Berzinsh I, et al. Immunochemical structure of the carboxy-terminal part of hepatitis B e antigen: identification of internal and surface-exposed sequences. J Gen Viro 1993;74(Pt 7):1335-40. (Pubitemid 23230250)
14. Bertoletti A, Ferrari C, Fiaccadori F, et al. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen. Proc Natl Acad Sci U S A 1991;88(23):10445-9. (Pubitemid 21915852)
15. Bertoletti A, Chisari FV, Penna A, et al. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 1993;67(4):2376-80. (Pubitemid 23088417)
16. Sallberg M, Ruden U, Magnius LO, Harthus HP, Noah M, Wahren B. Characterisation of a linear binding site for a monoclonal antibody to hepatitis B core antigen. J Med Virol 1991;33(4):248-52.
17. Salfeld J, Pfaff E, Noah M, Schaller H. Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus. J Virol 1989;63(2):798-808. (Pubitemid 19057248)
18. Wynne SA, Crowther RA, Leslie AG. The crystal structure of the human hepatitis B virus capsid. Mol Cell Jun 1999;3(6):771-80. (Pubitemid 29323055)
19. Chinchai T, Chirathaworn C, Praianantathavom K, et al. Long-term humoral and cellular immune response to hepatitis B vaccine in high-risk children 18-20 years after neonatal immunization. Viral Immunol 2009;22(2):125-30.
20. Li J, Wu W, Peng G, et al. HBcAg induces interleukin-10 production, inhibiting HBcAg-specific Th17 responses in chronic hepatitis B patients. Immunol Cell Bio 2010;88(8):834-41.
21. Arababadi MK, Mohammadzadeh A, Ahmadabadi BN, Pourfathollah AA, Kennedy D. Are Fas ligand polymorphisms associated with occult HBV infection? LabMedicine 2010;41:672-5.
22. Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G, Mohit M, Hajghani M. Peripheral blood NK cells CCR5 expression in Iranian patients with occult hepatitis B infection. Lab-Medicine 2010;41(12):19-22.
23. Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G. Serum levels of Interleukin (IL)-10 and IL-17A in occult HBV infected south-east Iranian patients. Hepat Mon 2010;10(1):31-5.