메뉴 건너뛰기




Volumn 88, Issue 8, 2010, Pages 834-841

HBcAg induces interleukin-10 production, inhibiting HBcAg-specific Th17 responses in chronic hepatitis B patients

Author keywords

CHB patients; cytokines; hepatitis B virus; regulation; Th17 cell responses

Indexed keywords

HEPATITIS B CORE ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; RECOMBINANT INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

EID: 78649326079     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2010.63     Document Type: Article
Times cited : (38)

References (41)
  • 1
    • 36348988986 scopus 로고    scopus 로고
    • T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: Facts and controversies
    • Manigold T, Racanelli V. T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies. Lancet Infect Dis 2007; 7: 804-813.
    • (2007) Lancet Infect Dis , vol.7 , pp. 804-813
    • Manigold, T.1    Racanelli, V.2
  • 2
    • 24344435917 scopus 로고    scopus 로고
    • Epidemiology and natural history of hepatitis B
    • McMahon BJ. Epidemiology and natural history of hepatitis B. Semin Liver Dis 2005; 25(Suppl 1): 3-8.
    • (2005) Semin Liver Dis , vol.25 , Issue.SUPPL. 1 , pp. 3-8
    • McMahon, B.J.1
  • 3
    • 0034678409 scopus 로고    scopus 로고
    • Intrahepatic T cells in hepatitis B: Viral control versus liver cell injury
    • Rehermann B. Intrahepatic T cells in hepatitis B: viral control versus liver cell injury. J Exp Med 2000; 191: 1263-1268.
    • (2000) J Exp Med , vol.191 , pp. 1263-1268
    • Rehermann, B.1
  • 4
    • 2442682870 scopus 로고    scopus 로고
    • + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 2004; 78: 5707-5719.
    • (2004) J Virol , vol.78 , pp. 5707-5719
    • Webster, G.J.1    Reignat, S.2    Brown, D.3    Ogg, G.S.4    Jones, L.5    Seneviratne, S.L.6
  • 5
    • 0027394383 scopus 로고
    • HLA-A31-and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleo-capsid epitope during acute viral hepatitis
    • Missale G, Redeker A, Person J, Fowler P, Guilhot S, Schlicht HJ et al. HLA-A31-and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleo-capsid epitope during acute viral hepatitis. J Exp Med 1993; 177: 751-762.
    • (1993) J Exp Med , vol.177 , pp. 751-762
    • Missale, G.1    Redeker, A.2    Person, J.3    Fowler, P.4    Guilhot, S.5    Schlicht, H.J.6
  • 8
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science 2009; 324: 1572-1576.
    • (2009) Science , vol.324 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 9
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5: 215-229.
    • (2005) Nat Rev Immunol , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 10
    • 0033199973 scopus 로고    scopus 로고
    • Virus-specific lymphokine production differs quantitatively but not qualitatively in acute and chronic hepatitis B infection
    • Jung MC, Hartmann B, Gerlach JT, Diepolder H, Gruber R, Schraut W et al. Virus-specific lymphokine production differs quantitatively but not qualitatively in acute and chronic hepatitis B infection. Virology 1999; 261: 165-172.
    • (1999) Virology , vol.261 , pp. 165-172
    • Jung, M.C.1    Hartmann, B.2    Gerlach, J.T.3    Diepolder, H.4    Gruber, R.5    Schraut, W.6
  • 11
    • 73449125874 scopus 로고    scopus 로고
    • Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B
    • Zhang JY, Zhang Z, Lin F, Zou ZS, Xu RN, Jin L et al. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 2009; 51: 81-91.
    • (2009) Hepatology , vol.51 , pp. 81-91
    • Zhang, J.Y.1    Zhang, Z.2    Lin, F.3    Zou, Z.S.4    Xu, R.N.5    Jin, L.6
  • 13
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    • Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 2008; 28: 29-39.
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6
  • 14
    • 46749125294 scopus 로고    scopus 로고
    • Shifting the imbalance from Th1/Th2 to Th17/treg: The changing rheumatoid arthritis paradigm
    • Boissier MC, Assier E, Falgarone G, Bessis N. Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm. Joint Bone Spine 2008; 75: 373-375.
    • (2008) Joint Bone Spine , vol.75 , pp. 373-375
    • Boissier, M.C.1    Assier, E.2    Falgarone, G.3    Bessis, N.4
  • 16
    • 33750282677 scopus 로고    scopus 로고
    • The IL-23/Th(17) axis: Therapeutic targets for autoimmune inflammation
    • Kikly K, Liu L, Na S, Sedgwick JD. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr Opin Immunol 2006; 18: 670-675.
    • (2006) Curr Opin Immunol , vol.18 , pp. 670-675
    • Kikly, K.1    Liu, L.2    Na, S.3    Sedgwick, J.D.4
  • 18
    • 77249158089 scopus 로고    scopus 로고
    • Implication of Th17 and Th1 cells in patients with chronic active hepatitis B
    • Ge J, Wang K, Meng QH, Qi ZX, Meng FL, Fan YC. Implication of Th17 and Th1 cells in patients with chronic active hepatitis B. J Clin Immunol 2009; 30: 60-67.
    • (2009) J Clin Immunol , vol.30 , pp. 60-67
    • Ge, J.1    Wang, K.2    Meng, Q.H.3    Qi, Z.X.4    Meng, F.L.5    Fan, Y.C.6
  • 19
    • 77950182472 scopus 로고    scopus 로고
    • Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients
    • Wu W, Li J, Chen F, Zhu H, Peng G, Chen Z. Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients. J Gastroenterol Hepatol 2009; 25: 750-757.
    • (2009) J Gastroenterol Hepatol , vol.25 , pp. 750-757
    • Wu, W.1    Li, J.2    Chen, F.3    Zhu, H.4    Peng, G.5    Chen, Z.6
  • 22
    • 0034995684 scopus 로고    scopus 로고
    • Immunopathogenesis of human immunodeficiency virus: Implications for immune-based therapies
    • Sereti I, Lane HC. Immunopathogenesis of human immunodeficiency virus: implications for immune-based therapies. Clin Infect Dis 2001; 32: 1738-1755.
    • (2001) Clin Infect Dis , vol.32 , pp. 1738-1755
    • Sereti, I.1    Lane, H.C.2
  • 23
    • 0026000892 scopus 로고
    • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression
    • de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915-924.
    • (1991) J Exp Med , vol.174 , pp. 915-924
    • De Waal Malefyt, R.1    Haanen, J.2    Spits, H.3    Roncarolo, M.G.4    Te Velde, A.5    Figdor, C.6
  • 24
    • 46949085507 scopus 로고    scopus 로고
    • Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells
    • Gu Y, Yang J, Ouyang X, Liu W, Li H, Bromberg J et al. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. Eur J Immunol 2008; 38: 1807-1813.
    • (2008) Eur J Immunol , vol.38 , pp. 1807-1813
    • Gu, Y.1    Yang, J.2    Ouyang, X.3    Liu, W.4    Li, H.5    Bromberg, J.6
  • 25
    • 0142242158 scopus 로고    scopus 로고
    • Frequencies of interferon-gamma and interleukin-10 secreting cells in peripheral blood mononuclear cells and liver infiltrating lymphocytes in chronic hepatitis B virus infection
    • Hyodo N, Tajimi M, Ugajin T, Nakamura I, Imawari M. Frequencies of interferon-gamma and interleukin-10 secreting cells in peripheral blood mononuclear cells and liver infiltrating lymphocytes in chronic hepatitis B virus infection. Hepatol Res 2003; 27: 109-116.
    • (2003) Hepatol Res , vol.27 , pp. 109-116
    • Hyodo, N.1    Tajimi, M.2    Ugajin, T.3    Nakamura, I.4    Imawari, M.5
  • 26
    • 0034047965 scopus 로고    scopus 로고
    • Soluble interleukin-2 receptor and interleukin-10 levels in patients with chronic hepatitis B infection
    • Tulek N, Saglam SK, Saglam M, Turkyilmaz R, Yildiz M. Soluble interleukin-2 receptor and interleukin-10 levels in patients with chronic hepatitis B infection. Hepatogas-troenterology 2000; 47: 828-831.
    • (2000) Hepatogas-troenterology , vol.47 , pp. 828-831
    • Tulek, N.1    Saglam, S.K.2    Saglam, M.3    Turkyilmaz, R.4    Yildiz, M.5
  • 28
    • 0023146403 scopus 로고
    • Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis. Evidence that antibody modulation may cause protracted infection
    • Pignatelli M, Waters J, Lever A, Iwarson S, Gerety R, Thomas HC. Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis. Evidence that antibody modulation may cause protracted infection. J Hepatol 1987; 4: 15-21.
    • (1987) J Hepatol , vol.4 , pp. 15-21
    • Pignatelli, M.1    Waters, J.2    Lever, A.3    Iwarson, S.4    Gerety, R.5    Thomas, H.C.6
  • 29
    • 0020459196 scopus 로고
    • Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: Evidence that T cells are directed against HBV core antigen expressed on hepatocytes
    • Mondelli M, Vergani GM, Alberti A, Vergani D, Portmann B, Eddleston AL et al. Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J Immunol 1982; 129: 2773-2778.
    • (1982) J Immunol , vol.129 , pp. 2773-2778
    • Mondelli, M.1    Vergani, G.M.2    Alberti, A.3    Vergani, D.4    Portmann, B.5    Eddleston, A.L.6
  • 31
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007; 8: 1390-1397.
    • (2007) Nat Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6
  • 32
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24: 179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 34
    • 33750092212 scopus 로고    scopus 로고
    • + monocytes of patients with chronic hepatitis B virus infection, which correlates with higher serum IL-10 levels
    • + monocytes of patients with chronic hepatitis B virus infection, which correlates with higher serum IL-10 levels. J Viral Hepat 2006; 13: 725-733.
    • (2006) J Viral Hepat , vol.13 , pp. 725-733
    • Geng, L.1    Jiang, G.2    Fang, Y.3    Dong, S.4    Xie, H.5    Al Et, C.Y.6
  • 35
    • 1542329250 scopus 로고    scopus 로고
    • Hepatitis B core antigen stimulates interleukin-10 secretion by both T cells and monocytes from peripheral blood of patients with chronic hepatitis B virus infection
    • Hyodo N, Nakamura I, Imawari M. Hepatitis B core antigen stimulates interleukin-10 secretion by both T cells and monocytes from peripheral blood of patients with chronic hepatitis B virus infection. Clin Exp Immunol 2004; 135: 462-466.
    • (2004) Clin Exp Immunol , vol.135 , pp. 462-466
    • Hyodo, N.1    Nakamura, I.2    Imawari, M.3
  • 36
    • 0030959049 scopus 로고    scopus 로고
    • Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B
    • Rossol S, Marinos G, Carucci P, Singer MV, Williams R, Naoumov NV. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J Clin Invest 1997; 99: 3025-3033.
    • (1997) J Clin Invest , vol.99 , pp. 3025-3033
    • Rossol, S.1    Marinos, G.2    Carucci, P.3    Singer, M.V.4    Williams, R.5    Naoumov, N.V.6
  • 37
    • 65449120436 scopus 로고    scopus 로고
    • IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells
    • Naundorf S, Schroder M, Hoflich C, Suman N, Volk HD, Grutz G. IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells. Eur J Immunol 2009; 39: 1066-1077.
    • (2009) Eur J Immunol , vol.39 , pp. 1066-1077
    • Naundorf, S.1    Schroder, M.2    Hoflich, C.3    Suman, N.4    Volk, H.D.5    Grutz, G.6
  • 38
    • 0035201803 scopus 로고    scopus 로고
    • Hepatitis B virus-specific T-cell proliferation and cytokine secretion in chronic hepatitis B e antibody-positive patients treated with ribavirin and interferon alpha
    • Rico MA, Quiroga JA, Subira D, Castanon S, Esteban JM, Pardo M et al. Hepatitis B virus-specific T-cell proliferation and cytokine secretion in chronic hepatitis B e antibody-positive patients treated with ribavirin and interferon alpha. Hepatology 2001; 33: 295-300.
    • (2001) Hepatology , vol.33 , pp. 295-300
    • Rico, M.A.1    Quiroga, J.A.2    Subira, D.3    Castanon, S.4    Esteban, J.M.5    Pardo, M.6
  • 39
    • 47749124186 scopus 로고    scopus 로고
    • Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
    • Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M et al. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem 2008; 283: 17003-17008.
    • (2008) J Biol Chem , vol.283 , pp. 17003-17008
    • Ichiyama, K.1    Yoshida, H.2    Wakabayashi, Y.3    Chinen, T.4    Saeki, K.5    Nakaya, M.6
  • 40
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    De Vries, J.E.5
  • 41
    • 0031799002 scopus 로고    scopus 로고
    • Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells
    • Du C, Sriram S. Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells. J Leukoc Biol 1998; 64: 92-97.
    • (1998) J Leukoc Biol , vol.64 , pp. 92-97
    • Du, C.1    Sriram, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.