Relationship between serum HBV DNA level and liver histology in HBV carriers with normal ALT in Guilan province, Iran

Medical Science Monitor

Volumn 16, Issue 3, 2010, Pages

  Mansour Ghanaei, Fariborz ^a   Rafiei, Rahmatollah ^a   Joukar, Farahnaz ^a   Naghipour, Mohammadreza ^a   Besharati, Sepideh ^a   Aminian, Keyvan ^a   Atrkar Roushan, Zahra ^a  

^a UNIVERSITY OF GUILAN   (Iran)

Author keywords

Guilan; HBV carriers; HBV DNA; Histology

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; AGE DISTRIBUTION; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CHRONIC HEPATITIS; DISEASE SEVERITY; DNA DETERMINATION; FEMALE; HEPATITIS; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IRAN; LIVER BIOPSY; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER NECROSIS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; VIRUS CARRIER;

ADULT; AGED; ALANINE TRANSAMINASE; CARRIER STATE; DNA, VIRAL; FEMALE; HEPATITIS B VIRUS; HUMANS; IRAN; LIVER; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 77649257576     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Zacharakis G, Koskinas J, Kotsiou S, Tzara F, Vafeiadis N, Papoutselis M, et al. The role of serial measurement of serum HBV DNA levels in patients with chronic HBeAg(-) hepatitis B infection: association with liver disease progression. A prospective cohort study. J Hepatol, 2008; 49(6): 884-91
2. Mansour-Ghanaei F,Sadeghi A, Yousefi Mashhour M et al: Prevalence of Hepatitis B and C Infection in Hemodialysis Patients of Rasht (Center of Guilan Province, Northern part of Iran), Hep Month J, 2009; 9(1): 45-49
3. Kumar SS, Saini N, Chwla Y: Hepatitis B Virus: Inactive carriers. Virol J, 2005; 2: 82
4. Chwla Y: Hepatitis B virus: inactive carriers. Virol J, 2005; 2: 82
5. Martinot-Peignoux M, Boyer N, Colombat M et al: Serum hepatitis B virus DNA levels and liver histology in inactive HBsAg carriers. J Hepatol, 2002; 36(4): 543-46
6. Zali MR, Mohammad K, Noorbala AA et al: Rate of hepatitis B seropositivity following mass vaccination in the Islamic Republic of Iran. East Mediterr Health J, 2005; 11(1-2): 62-67
7. Alizadeh AH, Ranjbar M, Ansari S et al: Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran. World J Gastroenterol, 2005; 11(31): 4857-60
8. Mansour-Ghanaei F, Fallah MS, Shafaghi A et al: Prevalence of hepatitis B and C seromarkers and abnormal liver function tests among hemophiliacs in Guilan (northern province of Iran). Med Sci Monit, 2002; 8(12): CR797-800
9. Xie Y, Zhao H, Dai WS, Xu DZ: HBV DNA level and antigen concentration in evaluating liver damage of patients with chronic hepatitis B. Hepatobiliary Pancreat Dis Int, 2003; 2(3): 418-22
10. Shao J, Wei L, Wang H et al: Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B. World J Gastroenterol, 2007; 13(14): 2104-7
11. Sung JJ, Chan HL, Wong ML et al: Relationship of clinical and virological factors with hepatitis activity in hepatitis B e antigen-negative chronic hepatitis B virus-infected patients. J Viral Hepat, 2002; 9(3): 229-34
12. Nabuco LC, Villela-Nogueira CA, Perez RM et al: HBV-DNA levels in HBsAg-positive blood donors and its relationship with liver histology. J Clin Gastroenterol, 2007; 41(2): 194-98
13. Zarski JP, Marcellin P, Leroy V et al: Characteristics of patients with chronic hepatitis B in France: predominant frequency of HBe antigen negative cases. J Hepatol, 2006; 45(3): 355-60
14. Xie Y, Zhao H, Dai WS, Xu DZ: HBV DNA level and antigen concentration in evaluating liver damage of patients with chronic hepatitis B. Hepatobiliary Pancreat Dis Int, 2003; 2(3): 418-22
15. Mommeja-Marin H, Mondou E, BlumMR, Rousseau F: Serum HBV DNA as a Marker of Efficacy During Therapy for Chronic HBV Infection: Analysis and Review of the Literature. Hepatology, 2003; 37(6): 1309-19
16. Heo J, Baik TH, Kim HH et al: Serum hepatitis B virus (HBV) DNA levels at different stages of clinical course in patients with chronic HBV infection in an endemic area. Journal of Korean Medical Science, 2003; 18(5): 686-90
17. Lok AS, Heathcote EJ, Hoofnagle JH: Management of hepatitis B: 2000 - summary of a workshop. Gastroenterology, 2001; 120(7): 1828-53
18. Lok AS, McMahon BJ: Chronic hepatitis B. Hepatology, 2007; 45(2): 507-39 [PMID: 17256718]
19. Lindh M, Andersson AS, Gusdal A: Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus-large-scale analysis using a new genotyping method. J Infect Dis, 1997; 175(6): 1285-93
20. Westland C, Delaney W, Yang H et al: Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil1. Gastroenterology, 2003; 125(1): 107-16
21. Hussain M, Chu CJ, Sablon E, Lok AS: Rapid and sensitive assays for determination of hepatitis B virus (HBV) genotypes and detection of HBV precore and core promoter variants. J Clin Microbiol, 2003; 41(8): 3699-705
22. Rodriguez-Frias F, Buti M, Jardi R et al: Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. Hepatology, 1995; 22(6): 1641-47
23. Mohamadnejad M, Montazeri G, Fazlollahi A et al: Noninvasive markers of liver fibrosis and inflammation in chronic hepatitis B-virus related liver disease. Am J Gastroenterol, 2006; 101(11): 2537-45
24. Iloeje UH, Yang HI, Su J et al: Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology, 2006; 130(3): 678-86
25. Chen CJ, Yang HI, Su J et al: Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA, 2006; 295(1): 65-73