Activation of jnk signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Shi, Long ^a   Chang, Yuan ^a   Yang, Yongmei ^a   Zhang, Ying ^a   Yu, Fu Shin X ^b   Wu, Xinyi ^a  

^a SHANDONG UNIVERSITY   (China)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; FLAVONOID; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; TELOMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; CORNEA INJURY; CORNEA STROMA; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SCAR FORMATION; SIGNAL TRANSDUCTION; WOUND HEALING; ANIMAL; CELL LINE; CORNEA; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EYE INJURY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SCAR; SECRETION; WISTAR RAT;

ANIMALS; ANTHRACENES; CELL LINE, TRANSFORMED; CICATRIX; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; CORNEA; CORNEAL STROMA; ENZYME ACTIVATION; EYE INJURIES, PENETRATING; FIBROBLASTS; FIBRONECTINS; FLAVONOIDS; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PYRIDINES; RATS; RATS, WISTAR; TELOMERASE; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 84857388963     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032128     Document Type: Article

References (44)

1. Limburg H, Barria von Bischhoffshausen F, Gomez P, Silva JC, Foster A, (2008) Review of recent surveys on blindness and visual impairment in Latin America. Br J Ophthalmol 92: 315-319.
2. Fukada T, Civic N, Furuichi T, Shimoda S, Mishima K, et al. (2008) The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. PLoS One 3: e3642.
3. Dessein A, Chevillard C, Arnaud V, Hou XY, Hamdoun AA, et al. (2009) Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes. Journal of Experimental Medicine 206: 2321-2328.
4. Kuiper EJ, Van Nieuwenhoven FA, de Smet MD, van Meurs JC, Tanck MW, et al. (2008) The Angio-Fibrotic Switch of VEGF and CTGF in Proliferative Diabetic Retinopathy. PLoS One 3: e2675.
5. Qi W, Chen X, Polhill TS, Sumual S, Twigg S, et al. (2006) TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. Am J Physiol Renal Physiol 290: F703-709.
6. Song JJ, Aswad R, Kanaan RA, Rico MC, Owen TA, et al. (2007) Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF-beta1 to induce mesenchymal cell condensation. J Cell Physiol 210: 398-410.
7. Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, et al. (2005) Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. J Cell Physiol 203: 447-456.
8. Guo F, Carter DE, Leask A, (2011) Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFbeta-dependent mechanism. PLoS One 6: e19756.
9. Phanish MK, Winn SK, Dockrell ME, (2010) Connective tissue growth factor-(CTGF, CCN2)-a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol 114: e83-92.
10. Chen CC, Lau LF, (2009) Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41: 771-783.
11. Shi Wen X, Leask A, Abraham D, (2008) Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev 19: 133-144.
12. Garrett Q, Khaw PT, Blalock TD, Schultz GS, Grotendorst GR, et al. (2004) Involvement of CTGF in TGF-beta1-stimulation of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress. Invest Ophthalmol Vis Sci 45: 1109-1116.
13. Blalock TD, Duncan MR, Varela JC, Goldstein MH, Tuli SS, et al. (2003) Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy. Invest Ophthalmol Vis Sci 44: 1879-1887.
14. Wu XY, Yang YM, Guo H, Chang Y, (2006) The role of connective tissue growth factor, transforming growth factor beta1 and Smad signaling pathway in cornea wound healing. Chin Med J (Engl) 119: 57-62.
15. Chang Y, Wu XY, (2009) The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea. J Int Med Res 37: 727-736.
16. Chang Y, Wu XY, (2010) JNK1/2 siRNA inhibits transforming-growth factor-beta1-induced connective tissue growth factor expression and fibrotic function in THSFs. Mol Cell Biochem 335: 83-89.
17. Daniels JT, Schultz GS, Blalock TD, Garrett Q, Grotendorst GR, et al. (2003) Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring. Am J Pathol 163: 2043-2052.
18. Blalock TD, Yuan R, Lewin AS, Schultz GS, (2004) Hammerhead ribozyme targeting connective tissue growth factor mRNA blocks transforming growth factor-beta mediated cell proliferation. Exp Eye Res 78: 1127-1136.
19. Zi Z, Klipp E, (2007) Constraint-Based Modeling and Kinetic Analysis of the Smad Dependent TGF-beta Signaling Pathway. PLoS One 2: e936.
20. Peterziel H, Unsicker K, Krieglstein K, (2002) TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane. J Cell Biol 159: 157-167.
21. Ge C, Xiao G, Jiang D, Franceschi RT, (2007) Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176: 709-718.
22. Imamichi Y, Waidmann O, Hein R, Eleftheriou P, Giehl K, et al. (2005) TGF beta-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4. Biol Chem 386: 225-236.
23. Lien SC, Usami S, Chien S, Chiu JJ, (2006) Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. Cell Signal 18: 1270-1278.
24. Suk FM, Chen CH, Lin SY, Cheng CJ, Yen SJ, et al. (2009) 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. Toxicol Lett 187: 22-27.
25. Utsugi M, Dobashi K, Ishizuka T, Masubuchi K, Shimizu Y, et al. (2003) C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts. Am J Respir Cell Mol Biol 28: 754-761.
26. Black SA Jr, Palamakumbura AH, Stan M, Trackman PC, (2007) Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase. J Biol Chem 282: 15416-15429.
27. Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, et al. (2005) Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol 166: 1405-1418.
28. Yamanaka O, Saika S, Ohnishi Y, Kim Mitsuyama S, Kamaraju AK, et al. (2007) Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice. Mol Vis 13: 1730-1739.
29. Cursiefen C, (2007) Immune privilege and angiogenic privilege of the cornea. Chem Immunol Allergy 92: 50-57.
30. Munireddy S, Kavalukas SL, Barbul A, (2010) Intra-abdominal healing: gastrointestinal tract and adhesions. Surg Clin North Am 90: 1227-1236.
31. Wang XM, Zhang YZ, Kim HP, Zhou ZH, Feghali Bostwick CA, et al. (2006) Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Journal of Experimental Medicine 203: 2895-2906.
32. Zhang J, Bian HJ, Li XX, Liu XB, Sun JP, et al. (2010) ERK-MAPK signaling opposes rho-kinase to reduce cardiomyocyte apoptosis in heart ischemic preconditioning. Mol Med 16: 307-315.
33. Bogoyevitch MA, Ngoei KR, Zhao TT, Yeap YY, Ng DC, (2010) c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges. Biochim Biophys Acta 1804: 463-475.
34. Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, et al. (2002) CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int 62: 1149-1159.
35. Leivonen SK, Hakkinen L, Liu D, Kahari VM, (2005) Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts. J Invest Dermatol 124: 1162-1169.
36. Xie S, Sukkar MB, Issa R, Oltmanns U, Nicholson AG, et al. (2005) Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 288: L68-76.
37. Sohn M, Tan Y, Klein RL, Jaffa AA, (2005) Evidence for low-density lipoprotein-induced expression of connective tissue growth factor in mesangial cells. Kidney Int 67: 1286-1296.
38. Secker GA, Shortt AJ, Sampson E, Schwarz QP, Schultz GS, et al. (2008) TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling. Exp Cell Res 314: 131-142.
39. Sugioka K, Yoshida K, Kodama A, Mishima H, Abe K, et al. (2010) Connective tissue growth factor cooperates with fibronectin in enhancing attachment and migration of corneal epithelial cells. Tohoku J Exp Med 222: 45-50.
40. Saika S, Okada Y, Miyamoto T, Yamanaka O, Ohnishi Y, et al. (2004) Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium. Invest Ophthalmol Vis Sci 45: 100-109.
41. Matsuda A, Tagawa Y, Matsuda H, Nishihira J, (1997) Expression of macrophage migration inhibitory factor in corneal wound healing in rats. Invest Ophthalmol Vis Sci 38: 1555-1562.
42. Pang K, Du L, Wu X, (2010) A rabbit anterior cornea replacement derived from acellular porcine cornea matrix, epithelial cells and keratocytes. Biomaterials 31: 7257-7265.
43. Guo H, Wu X, Yu FS, Zhao J, (2008) Toll-like receptor 2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu. Immunol Cell Biol 86: 271-276.
44. Ren M, Gao L, Wu X, (2010) TLR4: the receptor bridging Acanthamoeba challenge and intracellular inflammatory responses in human corneal cell lines. Immunol Cell Biol 88: 529-536.