Toll-like receptor 2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu

Immunology and Cell Biology

Volumn 86, Issue 3, 2008, Pages 271-276

  Guo, Hui ^a   Wu, Xinyi ^a   Yu, Fu Shin X ^b   Zhao, Jie ^a  

^a SHANDONG UNIVERSITY   (China)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Anti inflammatory cytokines; Corneal fibroblasts; Fusarium solu; Toll like receptor 2

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2;

ARTICLE; CONTROLLED STUDY; CORNEA CELL; CYTOKINE PRODUCTION; FIBROBLAST; FUSARIUM; FUSARIUM SOLU; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; CELL LINE, TRANSFORMED; CORNEA; EYE INFECTIONS, FUNGAL; FIBROBLASTS; FUSARIUM; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY; INTERLEUKIN-10; INTERLEUKIN-1BETA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2;

FUNGI; FUSARIUM;

EID: 41149122142     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/sj.icb.7100158     Document Type: Article

References (29)

1. Iyer SA, Tuli SS, Wagoner RC. Fungal keratitis: emerging trends and treatment outcomes. Eye Contact Lens 2006; 32: 267-271.
2. Sun XG, Zhang Y, Li R, Wang ZQ, Luo SY, Jin XY et al. Etiological analysis on ocular fungal infection in the period of 1989-2000. Chin Med J (Engl) 2004; 117: 598-600.
3. Zhang W, Pan Z, Wang Z, Jin X, Luo S, Zou Y et al. The variance of pathogenic organisms of purulent ulcerative keratitis. Zhonghua Yan Ke Za Zhi 2002; 38: 8-12.
4. Thomas PA, Geraldine P. Infectious keratitis. Curr Opin Infect Dis 2007; 20: 129-141.
5. Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003; 300: 1524-1525.
6. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21: 335-376.
7. Janeway Jr CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20: 197-216.
8. Akira S, Takeda K. Toll-like receptor signaling. Nat Rev Immunol 2004; 4: 499-511.
9. Mambula SS, Sau K, Henneke P, Golenbock DT, Levitz SM. Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus. J Biol Chem 2002; 277: 39320-39326.
10. Wu XY, Gao JL, Ren MY. Expression profiles and function of toll-like receptors in human corneal epithelia. Chin Med J (Engl) 2007; 120: 893-897.
11. Gao JL, Wu XY. Aspergillus fumigatus activate human corneal epithelial cells via toll-like receptor 2 and 4. Zhonghua Yan Ke Za Zhi 2006; 42: 628-633.
12. Netea MG, Warris A, Van der Meer JW, Fenton MJ, Verver-Janssen TJ, Jacobs LE et al. Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis 2003; 188: 320-326.
13. Rodriguez-Martinez S, Cancino-Diaz ME, Cancino-Diaz JC. Expression of CRAMP via PGN-TLR-2 and of a-defensin-3 via CpG-ODN-TLR-9 in corneal fibroblasts. Br J Ophthalmol 2006; 90: 378-382.
14. Kumar A, Zhang J, Yu FS. Innate immune response of corneal epithelial cells to Staphylococcus aureus infection: role of peptidoglycan in stimulating proinflammatory cytokine secretion. Invest Ophthalmol Vis Sci 2004; 45: 3513-3522.
15. Nadeau WJ, Pistole TG, McCormick BA. Polymorphonuclear leukocyte migration across model intestinal epithelia enhances Salmonella typhimurium killing via the epithelial derived cytokine IL-6. Microbes Infect 2002; 4: 1379-1387.
16. Bals R, Hiemstra PS. Innate immunity in the lung: how epithelia cells fight against respiratory pathogens. Eur Respir J 2004; 23: 327-333.
17. Netea MG, Ferwerda G, Van der Graaf CA, Van der Meer JW, Kullberg BJ. Recognition of fungal pathogens by toll-like receptors. Curr Pharm Des 2006; 12: 4195-4201.
18. Roeder A, Kirschning CJ, Rupec RA, Schaller M, Weindl G, Korting HC. Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol 2004; 42: 485-498.
19. Kumar A, Zhang J, Yu FS. Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Microbes Infect 2006; 8: 380-389.
20. Netea MG, Van der Graaf CA, Vonk AG, Verschueren I, Van der Meer JW, Kullberg BJ. The role of toll-like receptors in the defense against disseminated candidiasis. J Infect Dis 2002; 185: 1483-1489.
21. Xie L, Zhong W, Shi W, Sun S. Spectrum of fungal keratitis in north China. Ophthalmology 2006; 113: 1943-1948.
22. Re F, Strominger JL. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 2001; 276: 37692-37699.
23. Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH et al. Activation of toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 2004; 172: 2739-2743.
24. Sing A, Rost D, Tvardovskaia N, Wiedemann A, Kirschning CJ, Aepfelbacher M et al. Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin-10-mediated immunosuppression. J Exp Med 2002; 196: 1017-1024.
25. Netea MG, Sutmuller R, Hermann C, Van der Graaf CA, Van der Meer JW, van Krieken JH et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol 2004; 172: 3712-3718.
26. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and toll like receptor 2. J Exp Med 2003; 197: 1107-1117.
27. Uprichard SL, Boyd B, Althage A, Chisari FV. Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. Proc Natl Acad Sci USA 2005; 102: 773-778.
28. Sorensen DR, Leirdal M, Sioud M. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol 2003; 327: 761-766.
29. Nakamura H, Siddiqui SS, Shen X, Malik AB, Pulido JS, Kumar NM et al. RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis 2004; 10: 703-711.