Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Guo, Fen ^a   Carter, David E ^b   Leask, Andrew ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEBBISTATIN; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; FOCAL ADHESION KINASE 1; MESSENGER RNA; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; CDC6 PROTEIN, HUMAN; CDK6 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 6; ENDOTHELIN RECEPTOR; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CELL ACTIVITY; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; ENZYME INHIBITION; FIBROBLAST; FIBROBLAST CULTURE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE INDUCTION; GINGIVA; GINGIVAL FIBROBLAST; HUMAN; HUMAN CELL; MECHANICAL TENSION; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; RNA ANALYSIS; SCAR FORMATION; SKIN FIBROBLAST; TENSION; CLUSTER ANALYSIS; CYTOLOGY; DRUG EFFECT; GENETICS; MECHANICAL STRESS; METABOLISM; PHENOTYPE; SIGNAL TRANSDUCTION;

CELL CYCLE PROTEINS; CELL PROLIFERATION; CLUSTER ANALYSIS; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN-DEPENDENT KINASE 6; ENDOTHELIN-1; FIBROBLASTS; GENE EXPRESSION REGULATION; GINGIVA; HUMANS; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ENDOTHELIN; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSFORMING GROWTH FACTOR BETA;

EID: 79956106195     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019756     Document Type: Article

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