The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome

Journal of Molecular Biology

Volumn 416, Issue 4, 2012, Pages 571-578

  Bulkley, David ^a   Johnson, Francis ^b   Steitz, Thomas A ^a,c  

^a YALE UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

antibiotic; crystal structure; ribosome; thermorubin; translation inhibitor

Indexed keywords

ANTIBIOTIC AGENT; RIBOSOME RNA; THERMORUBIN; TRANSFER RNA; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BINDING SITE; DRUG BINDING; DRUG BINDING SITE; DRUG SOLUBILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; TRANSLATION INITIATION;

BACTERIA (MICROORGANISMS); THERMUS THERMOPHILUS;

EID: 84857372570     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.12.055     Document Type: Article

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