-
1
-
-
30444459043
-
-
Franks, N.P. Molecular targets underlying general anaesthesia. Br. J. Pharmacol. 147 (Suppl 1), S72-S81 (2006). This is an excellent review of the work on the molecular mechanisms of anesthesia and includes a great summary of the development of the hypotheses over time from Meyer-Overton to currently favored hypotheses of direct effects on proteins.
-
Franks, N.P. Molecular targets underlying general anaesthesia. Br. J. Pharmacol. 147 (Suppl 1), S72-S81 (2006). This is an excellent review of the work on the molecular mechanisms of anesthesia and includes a great summary of the development of the hypotheses over time from Meyer-Overton to currently favored hypotheses of direct effects on proteins.
-
-
-
-
2
-
-
0019307358
-
Determination and applications of MAC
-
Quasha, A.L., Eger, E.I, 2nd, and Tinker, J.H. Determination and applications of MAC. Anesthesiology 53, 315-334 (1980).
-
(1980)
Anesthesiology
, vol.53
, pp. 315-334
-
-
Quasha, A.L.1
Eger 2nd, E.I.2
Tinker, J.H.3
-
3
-
-
0036300680
-
Isoflurane hyperalgesia is modulated by nicotinic inhibition
-
Flood, P., Sonner, J.M., Gong, D., and Coates, KM. Isoflurane hyperalgesia is modulated by nicotinic inhibition. Anesthesiology 97, 192-198 (2002).
-
(2002)
Anesthesiology
, vol.97
, pp. 192-198
-
-
Flood, P.1
Sonner, J.M.2
Gong, D.3
Coates, K.M.4
-
4
-
-
0036164035
-
Isoflurane and nociception: Spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception
-
Kingery, W.S., Agashe, G.S., Guo, T.Z., Sawamura, S., Davies, M.F., Clark, J.D., Kobilka, B.K., and Maze, M. Isoflurane and nociception: Spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiology 96, 367-374 (2002).
-
(2002)
Anesthesiology
, vol.96
, pp. 367-374
-
-
Kingery, W.S.1
Agashe, G.S.2
Guo, T.Z.3
Sawamura, S.4
Davies, M.F.5
Clark, J.D.6
Kobilka, B.K.7
Maze, M.8
-
5
-
-
0027155901
-
Alterations in pain threshold and psychomotor response associated with subanaesthetic concentrations of inhalation anaesthetics in humans
-
Tomi, K., Mashimo, T., Tashiro, C., Yagi, M., Pak, M., Nishimura, S., Nishimura, M., and Yoshiya, I. Alterations in pain threshold and psychomotor response associated with subanaesthetic concentrations of inhalation anaesthetics in humans. Br. J. Anaesth. 70, 684-686 (1993).
-
(1993)
Br. J. Anaesth
, vol.70
, pp. 684-686
-
-
Tomi, K.1
Mashimo, T.2
Tashiro, C.3
Yagi, M.4
Pak, M.5
Nishimura, S.6
Nishimura, M.7
Yoshiya, I.8
-
6
-
-
0033861473
-
-
Zhang, Y., Eger, E.I,. 2nd, Dutton, R.C., and Sonner, J.M. Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration. Anesth. Analg. 91, 462-466 (2000). This is one of the first studies describing hyperalgesia induced by subanesthetic concentrations of a variety of inhaled anesthetics.
-
Zhang, Y., Eger, E.I,. 2nd, Dutton, R.C., and Sonner, J.M. Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration. Anesth. Analg. 91, 462-466 (2000). This is one of the first studies describing hyperalgesia induced by subanesthetic concentrations of a variety of inhaled anesthetics.
-
-
-
-
7
-
-
42349089480
-
-
Franks, N.P. General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal. Nat. Rev. Neurosci. 9, 370-386 (2008). This new outstanding review article includes an excellent overview of the systems involved in consciousness and sleep which may be involved in mediating the anesthetic induced loss of consciosness.
-
Franks, N.P. General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal. Nat. Rev. Neurosci. 9, 370-386 (2008). This new outstanding review article includes an excellent overview of the systems involved in consciousness and sleep which may be involved in mediating the anesthetic induced loss of consciosness.
-
-
-
-
8
-
-
4444370650
-
Neuronal PDZ domains: A promising new molecular target for inhaled anesthetics?
-
Tao, Y.X. and Johns, RA. Neuronal PDZ domains: A promising new molecular target for inhaled anesthetics? Mol. Interv. 4, 215-221 (2004).
-
(2004)
Mol. Interv
, vol.4
, pp. 215-221
-
-
Tao, Y.X.1
Johns, R.A.2
-
9
-
-
54349124083
-
General anesthetics sensitize the capsaicin receptor TRPV1
-
Epub ahead of print] DOI: 10.1124/mol.108.049684
-
Cornett, P., Matta, J., and Ahern, G. General anesthetics sensitize the capsaicin receptor TRPV1. Mol. Pharmacol. 2008 [Epub ahead of print] DOI: 10.1124/mol.108.049684.
-
(2008)
Mol. Pharmacol
-
-
Cornett, P.1
Matta, J.2
Ahern, G.3
-
10
-
-
47249119606
-
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation
-
Matta, J.A., Cornett, P.M., Miyares, R.L., Abe, K., Sahibzada, N., and Ahern, G.P. General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc. Natl. Acad. Sci. U.S.A. 105, 8784-8789 (2008).
-
(2008)
Proc. Natl. Acad. Sci. U.S.A
, vol.105
, pp. 8784-8789
-
-
Matta, J.A.1
Cornett, P.M.2
Miyares, R.L.3
Abe, K.4
Sahibzada, N.5
Ahern, G.P.6
-
11
-
-
24744446008
-
Pungent products from garlic activate the sensory ion channel TRPA1
-
Bautista, D.M., Movahed, P., Hinman, A., Axelsson, H.E., Sterner, O., Hogestatt, E.D., Julius, D., Jordt, S.E., and Zygmunt, P.M. Pungent products from garlic activate the sensory ion channel TRPA1. Proc. Natl. Acad. Sci. U.S.A. 102, 12248-12252 (2005).
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 12248-12252
-
-
Bautista, D.M.1
Movahed, P.2
Hinman, A.3
Axelsson, H.E.4
Sterner, O.5
Hogestatt, E.D.6
Julius, D.7
Jordt, S.E.8
Zygmunt, P.M.9
-
12
-
-
1642430679
-
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
-
Jordt, S.E., Bautista, D.M., Chuang, H.H., McKemy, D.D., Zygmunt, P.M., Hogestatt, E.D,, Meng, I.D., and Julius, D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265 (2004).
-
(2004)
Nature
, vol.427
, pp. 260-265
-
-
Jordt, S.E.1
Bautista, D.M.2
Chuang, H.H.3
McKemy, D.D.4
Zygmunt, P.M.5
Hogestatt, E.D.6
Meng, I.D.7
Julius, D.8
-
13
-
-
17644426325
-
Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing
-
Nagata, K., Duggan, A., Kumar, G., and Garcia-Anoveros, J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J. Neurosci. 25, 4052-4061 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 4052-4061
-
-
Nagata, K.1
Duggan, A.2
Kumar, G.3
Garcia-Anoveros, J.4
-
14
-
-
0345616438
-
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
-
Story, G.M., Peier, A.M., Reeve, A.J. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819-829 (2003).
-
(2003)
Cell
, vol.112
, pp. 819-829
-
-
Story, G.M.1
Peier, A.M.2
Reeve, A.J.3
-
15
-
-
1842475312
-
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
-
Bandell, M., Story, G.M., Hwang, S.W., Viswanath, V., Eid, S.R., Petrus, M.J., Earley, T.J., and Patapoutian, A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849-857 (2004).
-
(2004)
Neuron
, vol.41
, pp. 849-857
-
-
Bandell, M.1
Story, G.M.2
Hwang, S.W.3
Viswanath, V.4
Eid, S.R.5
Petrus, M.J.6
Earley, T.J.7
Patapoutian, A.8
-
16
-
-
33646045075
-
-
Bautista, D.M., Jordt, S.E., Nikai, T., Tsuruda, P.R., Read, A.J., Poblete, J., Yamoah, E.N., Basbaum, A.I., and Julius, D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269-1282 (2006). Using TRPA1 deficient mice, the authors of this article demonstrate the importance of TRPA1 as a general sensor for irritant chemicals.
-
Bautista, D.M., Jordt, S.E., Nikai, T., Tsuruda, P.R., Read, A.J., Poblete, J., Yamoah, E.N., Basbaum, A.I., and Julius, D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269-1282 (2006). Using TRPA1 deficient mice, the authors of this article demonstrate the importance of TRPA1 as a general sensor for irritant chemicals.
-
-
-
-
17
-
-
46749091281
-
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents
-
This study of the role of TRPA1 in airway irritation through cigarette smoke has direct relevance to the proposed mechanisms of irritant anesthetic effects
-
Andre, E., Campi, B., Materazzi, S. et al. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J. Clin. Invest. 118, 2574-2582 (2008). This study of the role of TRPA1 in airway irritation through cigarette smoke has direct relevance to the proposed mechanisms of irritant anesthetic effects.
-
(2008)
J. Clin. Invest
, vol.118
, pp. 2574-2582
-
-
Andre, E.1
Campi, B.2
Materazzi, S.3
-
18
-
-
34548094044
-
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
-
This is the first description of an endogenous activator of TRPA1
-
Trevisani, M., Siemens, J., Materazzi, S. et al. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc. Natl. Acad. Sci. U.S.A. 104, 13519-13524 (2007). This is the first description of an endogenous activator of TRPA1.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A
, vol.104
, pp. 13519-13524
-
-
Trevisani, M.1
Siemens, J.2
Materazzi, S.3
-
19
-
-
0030777012
-
-
Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., and Julius, D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997). In this classic paper, the authors describe the cloning and first characterization of TRPV1 which is the hallmark ion channel in peripheral nociceptors sensitive to heat.
-
Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., and Julius, D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997). In this classic paper, the authors describe the cloning and first characterization of TRPV1 which is the hallmark ion channel in peripheral nociceptors sensitive to heat.
-
-
-
-
20
-
-
0034646740
-
-
Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Basbaum, A.I., and Julius, D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313 (2000). This article was the first to investigate the role of the TRPV1 ion channel in nociception using TRPV1 knockout mice showing that the sensation of noxious heat is preserved while the development of thermal hyperalgesia is deficient.
-
Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Basbaum, A.I., and Julius, D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313 (2000). This article was the first to investigate the role of the TRPV1 ion channel in nociception using TRPV1 knockout mice showing that the sensation of noxious heat is preserved while the development of thermal hyperalgesia is deficient.
-
-
-
-
21
-
-
33747235382
-
-
Huang, J., Zhang, X., and McNaughton, P.A. Inflammatory pain: The cellular basis of heat hyperalgesia. Curr. Neuropharmacol. 4, 197-206 (2006). This is an excellent review of the mechanisms involved in the development of heat hyperalgesia after tissue injury and inflammation.
-
Huang, J., Zhang, X., and McNaughton, P.A. Inflammatory pain: The cellular basis of heat hyperalgesia. Curr. Neuropharmacol. 4, 197-206 (2006). This is an excellent review of the mechanisms involved in the development of heat hyperalgesia after tissue injury and inflammation.
-
-
-
-
22
-
-
56649105841
-
Inhaled anesthetics activate TRPA1 heterologously expressed in HEK cells
-
Chu, C., Schumacher, M.A., Bunnett, N.W., and Eilers, H. Inhaled anesthetics activate TRPA1 heterologously expressed in HEK cells. Anesth. Analg. 106, S-191 (2008).
-
(2008)
Anesth. Analg
, vol.106
-
-
Chu, C.1
Schumacher, M.A.2
Bunnett, N.W.3
Eilers, H.4
-
23
-
-
0042344937
-
Pronociceptive actions of isoflurane: A protective role for estrogen
-
Flood, P. and Daniel, D. Pronociceptive actions of isoflurane: A protective role for estrogen. Anesthesiology 99, 476-479 (2003).
-
(2003)
Anesthesiology
, vol.99
, pp. 476-479
-
-
Flood, P.1
Daniel, D.2
-
24
-
-
9444245277
-
Intranasal nicotine for postoperative pain treatment
-
Flood, P. and Daniel, D. Intranasal nicotine for postoperative pain treatment. Anesthesiology 101, 1417-1421 (2004).
-
(2004)
Anesthesiology
, vol.101
, pp. 1417-1421
-
-
Flood, P.1
Daniel, D.2
-
25
-
-
0034175743
-
The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice
-
Kingery, W.S., Guo, T.Z., Davies, M.F., Limbird, L., and Maze, M. The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain 85, 345-358 (2000).
-
(2000)
Pain
, vol.85
, pp. 345-358
-
-
Kingery, W.S.1
Guo, T.Z.2
Davies, M.F.3
Limbird, L.4
Maze, M.5
-
26
-
-
0029016736
-
Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain
-
Petersen-Felix, S., Arendt-Nielsen, L., Bak, P., Roth, D., Fischer, M., Bjerring, P., and Zbinden, A.M. Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain. Br. J. Anaesth. 75, 55-60 (1995).
-
(1995)
Br. J. Anaesth
, vol.75
, pp. 55-60
-
-
Petersen-Felix, S.1
Arendt-Nielsen, L.2
Bak, P.3
Roth, D.4
Fischer, M.5
Bjerring, P.6
Zbinden, A.M.7
-
27
-
-
0030048283
-
Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by evoked potentials
-
Roth, D., Petersen-Felix, S., Bak, P., Arendt-Nielsen, L., Fischer, M., Bjerring, P., and Zbinden, A.M. Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by evoked potentials. Br. J. Anaesth. 76, 38-42 (1996).
-
(1996)
Br. J. Anaesth
, vol.76
, pp. 38-42
-
-
Roth, D.1
Petersen-Felix, S.2
Bak, P.3
Arendt-Nielsen, L.4
Fischer, M.5
Bjerring, P.6
Zbinden, A.M.7
-
28
-
-
37549043931
-
Anesthesia matters: Patients anesthetized with propofol have less postoperative pain than those anesthetized with isoflurane
-
Cheng, S.S., Yeh, J., and Flood, P. Anesthesia matters: Patients anesthetized with propofol have less postoperative pain than those anesthetized with isoflurane. Anesth. Analg. 106, 264-269 (2008).
-
(2008)
Anesth. Analg
, vol.106
, pp. 264-269
-
-
Cheng, S.S.1
Yeh, J.2
Flood, P.3
-
29
-
-
33748944485
-
Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs
-
Lele, E., Petak, F., Fontao, F., Morel, D.R., and Habre, W. Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs. Acta Anaesthesiol. Scand. 50, 1145-1151 (2006).
-
(2006)
Acta Anaesthesiol. Scand
, vol.50
, pp. 1145-1151
-
-
Lele, E.1
Petak, F.2
Fontao, F.3
Morel, D.R.4
Habre, W.5
-
30
-
-
33750470065
-
Storeoperated Ca2+ influx in airway smooth muscle: Interactions between volatile anesthetic and cyclic nucleotide effects
-
Prakash, Y.S., Iyanoye, A., Ay, B., Sieck, G.C., and Pabelick, C.M. Storeoperated Ca2+ influx in airway smooth muscle: Interactions between volatile anesthetic and cyclic nucleotide effects. Anesthesiology 105, 976-983 (2006).
-
(2006)
Anesthesiology
, vol.105
, pp. 976-983
-
-
Prakash, Y.S.1
Iyanoye, A.2
Ay, B.3
Sieck, G.C.4
Pabelick, C.M.5
-
31
-
-
84884811850
-
Inhalational anaesthetics and cardioprotection
-
Weber, N.C. and Schlack, W. Inhalational anaesthetics and cardioprotection. Handb. Exp. Pharmacol. 182, 187-207 (2008).
-
(2008)
Handb. Exp. Pharmacol
, vol.182
, pp. 187-207
-
-
Weber, N.C.1
Schlack, W.2
-
32
-
-
34548676161
-
Anesthetics and brain protection
-
Head, B.P. and Patel, P. Anesthetics and brain protection. Curr. Opin. Anaesthesiol. 20, 395-399 (2007).
-
(2007)
Curr. Opin. Anaesthesiol
, vol.20
, pp. 395-399
-
-
Head, B.P.1
Patel, P.2
|