Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety - Fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 5, 2012, Pages 1699-1710

  Rydzik, Anna M ^a   Kulis, Marta ^a   Lukaszewicz, MacIej ^a   Kowalska, Joanna ^a   Zuberek, Joanna ^a   Darzynkiewicz, Zbigniew M ^a   Darzynkiewicz, Edward ^a   Jemielity, Jacek ^a  

^a UNIVERSITY OF WARSAW   (Poland)

Author keywords

Bioorganic chemistry; Enzymatic resistance; Imidodiphosphate; mRNA cap; Nucleotides; Translation inhibition

Indexed keywords

(2' O METHYLGUANOSIN 5' YL)IMIDODIPHOSPHATE; (7 METHYLGUANOSIN 5' YL)GUANOSIN 5' YL 1,2 IMIDOTETRAPHOSPHATE; (7 METHYLGUANOSIN 5' YL)GUANOSIN 5' YL 1,2 IMIDOTRIPHOSPHATE; (7 METHYLGUANOSIN 5' YL)GUANOSIN 5' YL 2,3 IMIDOTRIPHOSPHATE; (7 METHYLGUANOSIN 5' YL)GUANOSIN 5' YL 3,4 IMIDOTETRAPHOSPHATE; (7 METHYLGUANOSIN 5' YL)IMIDODIPHOSPHATE; (7,2' O DIMETHYLGUANOSIN 5' YL)GUANOSIN 5' YL 1,2 IMIDOTRIPHOSPHATE; (7,2' O DIMETHYLGUANOSIN 5' YL)GUANOSIN 5' YL 2,3 IMIDOTRIPHOSPHATE; (7,2' O METHYLGUANOSIN 5' YL)GUANOSIN 5' YL 1,2 IMIDOTETRAPHOSPHATE; (7,2' O METHYLGUANOSIN 5' YL)GUANOSIN 5' YL 3,4 IMIDOTETRAPHOSPHATE; (7,2' O METHYLGUANOSIN 5' YL)IMIDODIPHOSPHATE; (GUANOSIN 5' YL)IMIDODIPHOSPHATE; CAP BINDING PROTEIN; IMIDODIPHOSPHATE DERIVATIVE; INITIATION FACTOR 4E; INORGANIC PYROPHOSPHATASE; MESSENGER RNA; NUCLEOTIDE DERIVATIVE; PYROPHOSPHATASE DCPS; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME REGULATION; IC 50; MOLECULAR STABILITY; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; RNA ANALYSIS; RNA CAPPING; RNA TRANSLATION; SUBSTITUTION REACTION;

BIOMIMETIC MATERIALS; DIPHOSPHONATES; HUMANS; HYDROLYSIS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RNA CAP ANALOGS;

EUKARYOTA;

EID: 84857359449     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.013     Document Type: Article

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