Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 9, 2006, Pages 3223-3230

  Kalek, Marcin ^a   Jemielity, Jacek ^a   Darzynkiewicz, Zbigniew M ^a   Bojarska, Elzbieta ^a   Stepinski, Janusz ^a   Stolarski, Ryszard ^a   Davis, Richard E ^b   Darzynkiewicz, Edward ^a  

^a UNIVERSITY OF WARSAW   (Poland)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

5 mRNA cap; DcpS scavenger; Decapping; Hydrolysis resistance

Indexed keywords

CAPPED RNA; CARBENE; HUMAN DCPS ENZYME; MESSENGER RNA; NUCLEOSIDE; OXYGEN; PHOSPHATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORUS; PYROPHOSPHATE; TRISODIUM P 1 (7 METHYL) GUANOSINE P 3 GUANOSINE ALPHA:BETA METHYLENE TRIPHOSPHATE; TRISODIUM P 1 (7 METHYL) GUANOSINE P 3 GUANOSINE BETA:GAMMA METHYLENE TRIPHOSPHATE; TRISODIUM P 1 (7,3' O DIMETHYLGUANOSINE P 3 GUANOSINE ALPHA:BETA METHYLENE TRIPHOSPHATE; TRISODIUM P 1 (7,3' O DIMETHYLGUANOSINE) P 3 GUANOSINE BETA:GAMMA METHYLENE TRIPHOSPHATE; UNCLASSIFIED DRUG; ZINC CHLORIDE;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; DRUG BINDING; DRUG SYNTHESIS; ENZYME DEGRADATION; ENZYME STABILITY; GENETIC LINKAGE; HYDROLYSIS; RNA CAPPING;

ENDORIBONUCLEASES; HUMANS; HYDROLYSIS; MOLECULAR STRUCTURE; RNA CAPS; SUBSTRATE SPECIFICITY; TITRIMETRY;

EID: 33644984354     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.045     Document Type: Article

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