Locked nucleic acid (LNA)-Modified dinucleotide mRNA cap analogue: Synthesis, enzymatic incorporation, and utilization

Journal of the American Chemical Society

Volumn 131, Issue 18, 2009, Pages 6364-6365

  Kore, Anilkumar R ^a   Shanmugasundaram, Muthian ^a   Charles, Irudaya ^a   Vlassov, Alexander V ^a   Barta, Timothy J ^a  

^a Life Technologies Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL PROCESS; BIOLOGICAL PROPERTIES; BIOWARFARES; CAP-BINDING; DINUCLEOTIDES; EXPRESSION LEVELS; IN-VITRO; INFECTIOUS DISEASE; LOCKED NUCLEIC ACID; NONRADIOACTIVE; PROTEIN COMPLEXES; RNA POLYMERASE; THERAPEUTIC VACCINES;

AUDIO FREQUENCY AMPLIFIERS; INTERNET PROTOCOLS; NUCLEIC ACIDS; PROTEINS; RNA; STANDARDS; SYNTHESIS (CHEMICAL);

LOW NOISE AMPLIFIERS;

ANTISENSE OLIGODEOXYNUCLEOTIDE; DINUCLEOTIDE; GUANOSINE; LOCKED NUCLEIC ACID; LUCIFERASE; MESSENGER RNA; PROTEIN; PROTEIN ELF4E; RNA POLYMERASE; UNCLASSIFIED DRUG; BACTERIOPHAGE T7 RNA POLYMERASE; CAPPED RNA; DINUCLEOSIDE PHOSPHATE; DNA DIRECTED RNA POLYMERASE; OLIGONUCLEOTIDE; VACCINE; VIRUS PROTEIN;

ARTICLE; CHEMICAL REACTION; DRUG DELIVERY SYSTEM; EUKARYOTE; GENETIC TRANSCRIPTION; GENOTYPE; HELA CELL; IMMUNOTHERAPY; METHYLATION; MOLECULAR MODEL; NUCLEIC ACID SYNTHESIS; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; BIOSYNTHESIS; CHEMISTRY; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PROTEIN SYNTHESIS; RNA STABILITY; SYNTHESIS;

DINUCLEOSIDE PHOSPHATES; DNA-DIRECTED RNA POLYMERASES; GENETIC THERAPY; HUMANS; OLIGONUCLEOTIDES; PROTEIN BIOSYNTHESIS; RNA CAP ANALOGS; RNA STABILITY; RNA, MESSENGER; TRANSFECTION; VACCINES; VIRAL PROTEINS;

EID: 69949134881     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja901655p     Document Type: Article

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