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Volumn 34, Issue 5, 2010, Pages 993-1007

Towards mRNA with superior translational activity: Synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYLGUANOSINE; ARCA TETRAPHOSPHATE DERIVATIVE; INITIATION FACTOR 4E; MESSENGER RNA; PHOSPHATE; PHOSPHOROTHIOIC ACID; PYROPHOSPHATE; UNCLASSIFIED DRUG;

EID: 77952557529     PISSN: 11440546     EISSN: 13699261     Source Type: Journal    
DOI: 10.1039/b9nj00644c     Document Type: Article
Times cited : (36)

References (58)
  • 22
    • 77952573746 scopus 로고    scopus 로고
    • Only the ways in which the unmodified nucleotide is activated are taken into account, since there is practically no efficient method for activation of phosphorothioate nucleotides with an imidazole group
    • Only the ways in which the unmodified nucleotide is activated are taken into account, since there is practically no efficient method for activation of phosphorothioate nucleotides with an imidazole group
  • 26
    • 77952573864 scopus 로고    scopus 로고
    • In the case of 2a, we failed to obtain high quality transcripts in the first attempt, and the amount of compound was insufficient to repeat the experiment. Therefore, unfortunately only 2b was tested for translation efficincy in vitro
    • In the case of 2a, we failed to obtain high quality transcripts in the first attempt, and the amount of compound was insufficient to repeat the experiment. Therefore, unfortunately only 2b was tested for translation efficincy in vitro
  • 48
    • 77952579482 scopus 로고    scopus 로고
    • The differences in the phosphate designations between tri- and tetraphosphate cap analogs arise from the fact that due to biochemical nomenclature the α-phosphate is always the one attached to 5'-hydroxyl of mRNA transcript after incorporation of the cap analog into mRNA
    • The differences in the phosphate designations between tri- and tetraphosphate cap analogs arise from the fact that due to biochemical nomenclature the α-phosphate is always the one attached to 5'-hydroxyl of mRNA transcript after incorporation of the cap analog into mRNA


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.