Daunorubicin therapy is associated with upregulation of E3 ubiquitin ligases in the heart

Experimental Biology and Medicine

Volumn 237, Issue 2, 2012, Pages 219-226

  Sishi, Balindiwe J N ^a   Bester, Dirk J ^b   Wergeland, Anita ^c   Loos, Benjamin ^a   Jonassen, Anne K ^c   van Rooyen, Jacques ^b   Engelbrecht, Anna Mart ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b CAPE PENINSULA UNIVERSITY OF TECHNOLOGY   (South Africa)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

Antracyclines; Autophagy; Cardiotoxicity; Daunorubicin; Ubiquitin ligases

Indexed keywords

ATROGIN 1; BECLIN 1; CASPASE 3; DAUNORUBICIN; LIGHT CHAIN 3 PHOSPHATIDYLETHANOLAMINE; MUSCLE RING FINGER 1 PROTEIN; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P62; SERINE; TRANSCRIPTION FACTOR FKHR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ANTHRACYCLINE; BETA ACTIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA PRESSURE; APOPTOSIS; ARTICLE; AUTOPHAGY; BLOOD FLOW VELOCITY; CARDIOTOXICITY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOWN REGULATION; ENZYME INHIBITION; HEART FUNCTION; HEART OUTPUT; MALE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TOXICITY TESTING; UPREGULATION; ADULT; CYTOTOXICITY; DAUNORUBICIN INDUCED CARDIOTOXICITY; ENZYME ACTIVATION; HEART; HEART MUSCLE PERFUSION; INTRACELLULAR SIGNALING; PROTEIN CLEAVAGE; WESTERN BLOTTING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; DAUNORUBICIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MUSCLE PROTEINS; MYOCARDIUM; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84857345970     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2011.011106     Document Type: Article

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