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Volumn 3, Issue 3, 2012, Pages 711-722

Rationalising sequence selection by ligand assemblies in the DNA minor groove: The case for thiazotropsin A

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CONSTANT; DNA DUPLEXES; DNA RECOGNITION; FREE ENERGY OF BINDING; HYDROGEN-BOND FORMATION; INOSINE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND ASSEMBLIES; MINOR GROOVES; MODELLING STUDIES; SELF-ASSOCIATIONS; SITE SELECTIVITY; SMALL MOLECULES; STERIC BULK; STRUCTURE DEPENDENCE; THERMODYNAMIC PARAMETER; VAN DER WAALS INTERACTIONS;

EID: 84857263513     PISSN: 20416520     EISSN: 20416539     Source Type: Journal    
DOI: 10.1039/c2sc00630h     Document Type: Article
Times cited : (24)

References (41)
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    • Drug-DNA Interaction Protocols
    • For a general reference on biophysical methods applied to drug-DNA interaction studies see, ed., Humana Press Inc., Totowa, NJ, USA
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    • (2010) Methods in Molecular Biology , vol.613
    • Fox, K.R.1
  • 23
    • 0025109561 scopus 로고
    • We are in the process of studying in detail the influence of ligand self-assembly on DNA minor groove recognition and will subsequently report the details of our observations in this regard in a further article. For the purposes of this article, however, the observation of negative NOEs for thiazotropsin A in free aqueous solution at room temperature indicates that this molecule self-assembles as a result of hydrophobic and π-π interactions
    • J. A. Parkinson J. Barber K. T. Douglas J. Rosamund D. Sharples Biochemistry 1990 29 10181
    • (1990) Biochemistry , vol.29 , pp. 10181
    • Parkinson, J.A.1    Barber, J.2    Douglas, K.T.3    Rosamund, J.4    Sharples, D.5
  • 27
    • 34247202518 scopus 로고    scopus 로고
    • Applications of Biocalorimetry: Binding, Stability and Enzyme Kinetics
    • ed. J. E. Ladbury and M. Doyle, John Wiley and Sons, Ltd.
    • R. O'Brien and I. Haq Applications of Biocalorimetry: Binding, Stability and Enzyme Kinetics, Biocalorimetry 2, ed., J. E. Ladbury, and, M. Doyle, John Wiley and Sons, Ltd., 2004
    • (2004) Biocalorimetry 2
    • O'Brien, R.1    Haq, I.2
  • 40
    • 84857311452 scopus 로고    scopus 로고
    • British Patent Application, PCT/GB02/05916
    • A. I. Khalaf, C. J. Suckling, R. D. Waigh British Patent Application, 2002, PCT/GB02/05916
    • (2002)
    • Khalaf, A.I.1    Suckling, C.J.2    Waigh, R.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.