Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1)

Biochemistry and Cell Biology

Volumn 89, Issue 6, 2011, Pages 562-577

  Dubé, Annie ^a   Harrisson, Jean François ^a   Saint Gelais, Geneviève ^a   Séguin, Carl ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Activation; Hypoxia; Hypoxia inducible factor 1 (HIF 1 ); Metal responsive transcription factor 1 (MTF 1); Protein kinase; Signal transduction

Indexed keywords

2-FACTORS; CHROMATIN IMMUNOPRECIPITATION ANALYSIS; CO-IMMUNOPRECIPITATION EXPERIMENTS; DIRECT INTERACTIONS; DNA-BINDING; ELECTRON TRANSPORT CHAIN; GENE INDUCTION; GENE TRANSCRIPTIONS; GENES ENCODING; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTORS; METAL REGULATORY ELEMENTS; METAL-RESPONSIVE TRANSCRIPTION FACTOR-1 (MTF-1); METALLOTHIONEINS; N-ACETYLCYSTEINE; PROTEIN KINASE; SIGNALING PATHWAYS; TRANSACTIVATION;

CHEMICAL ACTIVATION; EXPERIMENTS; GENES; METALS; MOLECULAR BIOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; ZINC;

TRANSCRIPTION;

ACETYLCYSTEINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METAL RESPONSIVE TRANSCRIPTION FACTOR 1; METALLOTHIONEIN; METALLOTHIONEIN I; MYXOTHIAZOL; OXYGENASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR; ROTENONE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; GENE INDUCTION; GENETIC TRANSCRIPTION; HYPOXIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ACETYLCYSTEINE; ANIMALS; BLOTTING, NORTHERN; CELL HYPOXIA; CHLORIDES; CHROMOSOME MAPPING; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENES, REPORTER; HEK293 CELLS; HEP G2 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOPRECIPITATION; LUCIFERASES; METALLOTHIONEIN; METHACRYLATES; MICE; MUTAGENESIS, SITE-DIRECTED; NIH 3T3 CELLS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PLASMIDS; PROMOTER REGIONS, GENETIC; PROTEIN KINASE INHIBITORS; PROTEIN STABILITY; ROTENONE; SIGNAL TRANSDUCTION; THIAZOLES; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; ZINC COMPOUNDS;

EID: 84857242311     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/o11-063     Document Type: Article

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