The case for autoimmunity in glaucoma

Experimental Eye Research

Volumn 93, Issue 2, 2011, Pages 187-190

  Wax, Martin B ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autoantibodies; Autoimmune; Glaucoma; Heat shock proteins

Indexed keywords

MYOCILIN; OPTINEURIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; DISEASE EXACERBATION; GENE MUTATION; GLAUCOMA; HEART DISEASE; HUMAN; INTRAOCULAR PRESSURE; MYOPIA; NEUROPATHY; OPTIC NERVE; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; STRESS;

AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; GLAUCOMA; HEAT-SHOCK PROTEINS; HUMANS; INTRAOCULAR PRESSURE;

EID: 80052788698     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2010.08.016     Document Type: Article

References (34)

1. Cartwright M.J., Grajewski A.L., Friedberg M.L., Anderson D.R., Richards D.W. Immune-related disease and normal-tension glaucoma. A case-control study. Arch. Ophthalmol. 1992, 110:500-502.
2. Flavell R.A., Hafler D.A. Autoimmunity. What is the turning point?. Curr. Opin. Immunol. 1999, 1999(11):635-637.
3. Foteinos G., Xu Q. Immune-mediated mechanisms of endothelial damage in atherosclerosis. Autoimmunity 2009, 42:627-633.
4. Franklin T.B., Krueger-Naug A.M., Clarke D.B., Arrigo A.P., Currie R.W. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. Int. J. Hyperthermia 2005, 21:379-392.
5. Grus F.H., Joachim S.C., Bruns K., et al. Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States. Invest. Ophthalmol. Vis. Sci. 2006, 47:968-976.
6. Grus F.H., Joachim S.C., Wuenschig D., Rieck J., Pfeiffer N. Autoimmunity and glaucoma. J. Glaucoma 2008, 17:79-84.
7. Joachim S.C., Pfeiffer N., Grus F.H. Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens. Graefes Arch. Clin. Exp. Ophthalmol. 2005, 243:817-823.
8. Kountouras J., Mylopoulos N., Boura P., Bessas C., Chatzopoulos D., Venizelos J., Zavos C. Relationship between Helicobacter pylori infection and glaucoma. Ophthalmology 2001, 108:599-604.
9. Kremmer S., Kreuzfelder E., Klein R., Bontke N., Henneberg-Quester K.B., Steuhl K.P., Grosse-Wilde H. Antiphosphatidylserine antibodies are elevated in normal tension glaucoma. Clin. Exp. Immunol. 2001, 125:211-215.
10. Maruyama I., Ohguro H., Ikeda Y. Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2000, 41:1657-1665.
11. Pigino G., Morfini G., Atagi Y., Deshpande A., Yu C., Jungbauer L., LaDu M., Busciglio J., Brady S. Disruption of fast axonal transport is a pathogenic mechanism forintraneuronal amyloid beta. Proc. Natl. Acad. Sci. U S A. 2009, 106:5907-5912.
12. Romano C., Barrett D.A., Li Z., et al. Anti-rhodopsin antibodies in sera from patients with normal-pressure glaucoma. Invest. Ophthal Vis. Sci. 1995, 36:1968-1975.
13. Romano C., Li Z., Arendt A., Hargrave P.A., Wax M.B. Epitope mapping of antirhodopsin antibodies from patients with normal pressure glaucoma. Invest. Ophthalmol. Vis. Sci. 1999, 40:1275-1281.
14. Schwartz M. Neurodegeneration and neuroprotection in glaucoma: development of a therapeutic neuroprotective vaccine: the Friedenwald lecture. Invest. Ophthalmol. Vis. Sci. 2003, 44:1407-1411.
15. Schett G., Xu Q., Amberger A., Van der Zee R., Recheis H., Willeit J., Wick G. Autoantibodies against heat shock protein 60 mediate endothelialcytotoxicity. J. Clin. Invest. 1995, 96:2569-2577.
16. Spencer P., Schaumburg H. Ultrastructural studies of the dying-back process. IV. Differential vulnerability of PNS and CNS fibers in experimental central- peripheral distal axonopathies. J. Neuropathol. Exp. Neurol. 1977, 36:300-320.
17. Stevens B., Allen N.J., Vazquez L.E., Howell G.R., Christopherson K.S., Nouri N., Micheva K.D., Mehalow A.K., Huberman A.D., Stafford B., Sher A., Litke A.M., Lambris J.D., Smith S.J., John S.W., Barres B.A. The classical complement cascade mediates CNS synapse elimination. Cell 2007, 131:1164-1178.
18. Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog. Retin. Eye. Res. 2006, 25:490-513.
19. Tezel G., Edward D.P., Wax M.B. Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma. Arch. Ophthalmol. 1999, 117:917-924.
20. Tezel G., Hernandez M.R., Wax M.B. Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch. Ophthalmol. 2000, 118:511-518.
21. Tezel G., Seigel G.M., Wax M.B. Autoantibodies to small heat shock proteins in glaucoma. Invest. Ophthalmol. Vis. Sci. 1998, 39:2277-2287.
22. Tezel G., Wax M.B. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J. Neurosci. 2000, 20:3552-3562.
23. Tezel, G., Yang, X., Luo, C., Kain, A., Powell, D., Kuehn, M.H., Kaplan, H.J., Oxidative stress and the regulation of complement activation in human glaucoma. Invest. Ophthalmol. Vis. Sci., 2010 May 19. [Epub ahead of print].
24. Wax M.B., Barrett D.A., Pestronk A. Increased incidence of paraproteinemia and autoantibodies in patients with normal-pressure glaucoma. Am. J. Ophthalmol. 1994, 117:561-568.
25. Wax M.B., Tezel G. The immune system and glaucoma. Curr. Opin. Ophthalmol. 2004, 15:80-84.
26. Wax M.B., Tezel G. Immunoregulation of RGC fate in glaucoma. Exp. Eye Res. 2009, 88:825-830.
27. Wax M.B., Tezel G., Edward P.D. Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma. Arch. Ophthalmol. 1998, 116:993-1001. [see comments].
28. Wax M.B., Tezel G., Saito I., Gupta R.S., Harley J.B., Li Z., Romano C. AntiRo/SS-A positivity and heat shock protein antibodies in patients with normal pressure glaucoma. Am. J. Ophthalmol. 1998, 125:145-157.
29. Wax M.B., Tezel G., Yang J., Peng G., Patil R.V., Agarwal N., Sappington R.M., Calkins D.J. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J. Neurosci 2008, 28:12085-12096.
30. Weinreb R.N., Khaw P.T. Primary open-angle glaucoma. Lancet 2004, 363:1711-1720.
31. Yang J., Patil R.V., Yu H., Gordon M., Wax M.B. T cell subsets and sIL-2R/IL2 levels in patients with glaucoma. Am. J. Ophthalmol 2001, 131:421-426.
32. Yano T., Yamada K., Kimura A., Takeshita T., Minohara M., Kira J., Senju S., Nishimura Y., Tanihara H. Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma. Immunol. Lett. 2005, 100:164-169.
33. Young D.B. Heat-shock proteins: immunity and autoimmunity. Curr. Opin. Immunol 1992, 4:396-400.
34. Young R.A., Elliott T.J. Stress proteins, infection, and immune surveillance. Cell 1989, 59:5-8.