Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

Mucosal Immunology

Volumn 5, Issue 2, 2012, Pages 194-206

  Malvin, N P ^a   Seno, H ^a   Stappenbeck, T S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; DEXTRAN SULFATE; MYELOID DIFFERENTIATION FACTOR 88;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE MARROW CELL; CELL ACTIVATION; CELL TYPE; COLON INJURY; COLON MUCOSA; CONTROLLED STUDY; DNA MODIFICATION; HOMEOSTASIS; INTESTINE CRYPT; MESENCHYME; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL;

EID: 84857224309     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2011.65     Document Type: Review

References (53)

1. Ley, R. E ., Peterson, D. A. & Gordon, J. I. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124, 837-848 (2006). (Pubitemid 43261456)
2. Hill, D. A. & Artis, D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu. Rev. Immunol. 28, 623-667 (2010).
3. Hooper, L. V. & Macpherson, A. J. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat. Rev. Immunol. 10, 159-169 (2010).
4. Abreu, M. T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat. Rev. Immunol. 10, 131-144 (2010).
5. Chang, W. W. & Leblond, C. P. Renewal of the epithelium in the descending colon of the mouse. Am. J. Anat. 131, 73-99 (1971).
6. Li, L. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. Science 327, 542-545 (2010).
7. Walker, M. R ., Patel, K. K. & Stappenbeck, T. S. The stem cell niche. J. Pathol. 217, 169-180 (2008).
8. Seno, H ., Miyoshi, H ., Brown, S. L ., Geske, M. J ., Colonna, M. & Stappenbeck, T. S. Efficient colonic mucosal wound repair requires Trem-2 signaling. Proc. Natl. Acad. Sci. USA 106, 256-261 (2009).
9. Stappenbeck, T. S. & Miyoshi, H. The role of stromal stem cells in tissue regeneration and wound repair. Science 324, 1666-1669 (2009).
10. Pull, S. L ., Doherty, J. M ., Mills, J. C ., Gordon, J. I. & Stappenbeck, T. S. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc. Natl. Acad. Sci. USA 102, 99-104 (2005). (Pubitemid 40094435)
11. Ghia, J ., Galeazzi, F ., Ford, D. C ., Hogaboam, C. M ., Vallance, B. A. & Collins, S. Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G770-G777 (2008). (Pubitemid 351468763)
12. Lucas, T. et al. Differential roles of macrophages in diverse phases of skin repair. J. Immunol. 184, 3964-3977 (2010).
13. Brown, S. et al. Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J. Clin. Invest. 117, 258-269 (2007). (Pubitemid 46048471)
14. Rakoff-Nahoum, S ., Paglino, J ., Eslami-Varzaneh, J ., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-Like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004). (Pubitemid 38962578)
15. Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell. 2, 253-258 (1998). (Pubitemid 128373651)
16. Schnare, M ., Barton, G. M ., Holt, A. C ., Takeda, K ., Akira, S. & Medzhitov, R. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2, 947-950 (2001). (Pubitemid 32976167)
17. Otte, J ., Rosenberg, I. M. & Podolsky, D. K. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 124, 1866-1878 (2003). (Pubitemid 36666782)
18. Vamadevan, A. S ., Fukata, M ., Arnold, E. T ., Thomas, L. S ., Hsu, D. & Abreu, M. T. Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. Innate Immun. 16, 93-103 (2010).
19. Wang, D ., Mann, J. R. & DuBois, R. N. The role of prostglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology 128, 1445-1461 (2005). (Pubitemid 40712194)
20. Sonoshita, M ., Takaku, K ., Oshima, M ., Sigihara, K. & Taketo, M. Cyclooxygenase2 expression in fibroblasts and endothelial cell of intestinal polyps. Can. Res. 62, 6846-6849 (2002). (Pubitemid 35424071)
21. Walker, M. R ., Brown, S. L ., Riehl, T. E ., Stenson, W. F. & Stappenbeck, T. S. Growth factor regulation of prostaglandin-endoperoxide synthase 2 (Ptgs2) expression in colonic mesenchymal stem cells. J. Biol. Chem. 285, 5026-5039 (2009).
22. Nomura, T ., Chang, H. Y ., Lu, R ., Hankin, J ., Murphy, R. C. & Schuster, V. L. Prostaglandin signaling in the renal collecting duct. J. Biol. Chem. 280, 28424-28429 (2005).
23. Koch, S. et al. The wnt antagonist dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology 141, 259-268 (2011).
24. Srinivas, S ., Watanabe, T ., Lin, C ., William, C. M ., Tanabe, Y ., Jessell, T. M. & Constantini, F. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 1471-1478 (2001).
25. Lavine, K ., Schmid, G ., Smith, C. & Ornitz, D. Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and cornonary vascular growth represent distinct developmental programs. Dev. Dyn. 237, 713-724 (2008). (Pubitemid 351398037)
26. Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Gen. 21, 70-71 (1999). (Pubitemid 29036285)
27. Cross, M ., Mangelsdorf, I ., Wedel, A. & Renkawitz, R. Mouse lysozyme M gene: isolation, characterization, and expression studies. Proc. Natl. Acad. Sci. USA 85, 6232-6236 (1988).
28. Clausen, B. E ., Burkhardt, C ., Reith, W ., Renkaritz, R. & Forster, I. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 8, 265-277 (1999). (Pubitemid 29523965)
29. Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143-150 (1998). (Pubitemid 28361303)
30. Davies, J. Q. & Gordon, S. Isolation and culture of murine macrophages. In: Methods in Molecular Biology, Vol 290, Basic Cell Culture Protocols 3rd edn (Helgason, C.D. & Miller, C.L., eds). 91-103 (Humana Press, Totowa, NJ, 2004).
31. Peiser, L ., Gordon, S. & Haworth, R. Isolation and measuring the function of professional phagocytes, murine macrophages. In: Methods in Microbiology, Vol. 32, Immunology of Infection 2nd edn (D. Kabelitz, ed). 331-335 (Academic Press Science: London, 2002 ).
32. Ozaki, H. et al. Isolation and characterization of resident macrophages from the smooth muscle layers of murine small intestine. Neurogastroenterol. Motil. 16, 39-51 (2004). (Pubitemid 38253521)
33. Kumagai, K ., Itoh, K ., Hinuma, S. & Tada, M. Pretreatment of plastic petri dishes with fetal calf serum. A simple method for macrophage isolation. J. Immunol. Methods 29, 17-25 (1979).
34. Zanzinger, K ., Schellack, C ., Nausch, N. & Cerwenka, A. Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes. Immunology 128, 185-195 (2009).
35. Hathcock, K. S ., Laszlo, G ., Pucillo, C ., Linsley, P. & Hodes, R. J. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180, 631-640 (1994). (Pubitemid 24224140)
36. Mosser, D. M. The many faces of macrophage activation. J. Leukocyte Biol. 73, 209-212 (2003). (Pubitemid 36158295)
37. Edwards, J. P ., Zhang, X ., Frauwirth, K. A. & Mosser, D. M. Biochemical and functional characterization of three activated macrophage populations. J. Leukocyte Biol. 80, 1298-1307 (2006). (Pubitemid 44904968)
38. Nolan, A. et al. Differential role for CD80 and CD86 in regulation of the innate immune response in murine polymicrobial sepsis. PloS One 4, e6600 (2009).
39. Vlantis, K. et al. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J. Clin. Invest. 121, 2781-2793 (2011).
40. Jiang, D. et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 11, 1173-1179 (2005). (Pubitemid 43093664)
41. Macedo, L ., Pinhal-Enfield, G ., Alshits, V ., Elson, G ., Cronstein, B. N. & Leibovich, S. J. Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors. Am. J. Pathol. 171, 1774-1788 (2007).
42. Rakoff-Nahoum, S. & Medzhitov, R. Toll-like receptors and cancer. Nat. Rev. Cancer 9, 57-63 (2009).
43. Gibson, D. L ., Ma, C ., Bergstrom, K. S ., Huang, J. T ., Man, C. & Vallance, B. A. MyD88 signaling plays a critical role in host defense by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis. Cell Microbiol. 10, 618-631 (2008). (Pubitemid 351194091)
44. Hou, B ., Reizis, B. & DeFranco, A. L. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity 29, 272-282 (2008).
45. Kleinridders, A. et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 10, 249-259 (2009).
46. Vaishnava, S ., Behrendt, C ., Ismail, A ., Eckmann, L. & Hooper, L. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 105, 20858-20863 (2008).
47. Asquith, M. J ., Boulard, O ., Powrie, F. & Maloy, K. J. Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology 139, 519-529 (2010).
48. Brandl, K. et al. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc. Natl. Acad. Sci. USA 107, 19967-19972 (2010).
49. Reindl, W ., Weiss, S ., Lehr, H. A. & Förster, I. Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloidspecific signal transducer and activator of transcription 3-deficient mice. Immunology 120, 19-27 (2006). (Pubitemid 44950466)
50. Podjil, J ., Kin, N. W. & Sanders, V. M. CD86 and 2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B expression and binding to the 3-IgH enhancer in B Cells. J. Biol. Chem. 279, 23394-23404 (2004). (Pubitemid 38685649)
51. Bull, D. M. & Bookman, M. A. Isolation and functional characterization of human intestinal mucosal lymphoid cells. J. Clin. Invest. 59, 966-974 (1977). (Pubitemid 8096349)
52. Rogler, M. et al. Isolation and phenotypic characterization of colonic macrophages. Clin. Exp. Immunol. 112, 205-215 (1997).
53. Schenk, M ., Bouchon, A ., Birrer, S ., Colonna, M. & Mueller, C. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J. Immunol. 174, 517-524 (2005). (Pubitemid 40007442)