Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Han, Jieun ^a   Kim, Hyun Jung ^b,c   Lee, Sang Chul ^a,d   Hong, Seungpyo ^a   Park, Keunwan ^a   Jeon, Young Ho ^b   Kim, Dongsup ^a   Cheong, Hae Kap ^b   Kim, Hak Sung ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Chungbuk National University   (South Korea)

^d Institute Pasteur Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; TOLL LIKE RECEPTOR 4 DECOY RECEPTOR; UNCLASSIFIED DRUG; HYBRID PROTEIN; LY96 PROTEIN, HUMAN; MUTANT PROTEIN; PROTEIN MD 2; TLR4 DECOY;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; WILD TYPE; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DESIGN; GENETICS; HUMAN; METABOLISM; MUTATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LYMPHOCYTE ANTIGEN 96; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; THERMODYNAMICS;

EID: 84857186941     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030929     Document Type: Article

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