Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genes

Translational Psychiatry

Volumn 2, Issue , 2012, Pages

  Agren, T ^a   Furmark, T ^a   Eriksson, E ^b   Fredrikson, M ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

dopamine; fear conditioning; genes; memory reconsolidation; polymorphism; serotonin

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; SEROTONIN; SEROTONIN TRANSPORTER; VALINE;

ADULT; ALLELE; ARTICLE; ELECTRODERMAL RESPONSE; FEAR; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY CONSOLIDATION; SEROTONIN TRANSPORTER GENE;

ADULT; ALLELES; ANXIETY DISORDERS; AROUSAL; CATECHOL O-METHYLTRANSFERASE; CONDITIONING, CLASSICAL; DOPAMINE; EXTINCTION, PSYCHOLOGICAL; FEAR; FEMALE; GALVANIC SKIN RESPONSE; HOMOZYGOTE; HUMANS; MALE; MENTAL RECALL; POLYMORPHISM, GENETIC; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 84857173300     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2012.5     Document Type: Article

References (48)

1. Milad MR, Orr SP, Lasko NB, Chang Y, Rauch SL, Pitman RK. Presence and acquired origin of reduced recall for fear extinction in PTSD: Results of a twin study. J. Psychiatr Res 2008; 42: 515-520.
2. Mahan AL, Ressler KJ. Fear conditioning, synaptic plasticity and the amygdala: Implications for posttraumatic stress disorder. Trends Neurosci 2011; 35: 1-12.
3. McGaugh JL. Memory-a century of consolidation. Science 2000; 287: 248-251.
4. Nader K, Hardt O. A single standard for memory: The case for reconsolidation. Nat Rev Neurosci 2009; 10: 224-234.
5. Soeter M, Kindt M. Disrupting reconsolidation: Pharmacological and behavioral manipulations. Learn Mem 2011; 18: 357-366.
6. Kindt M, Soeter M, Vervliet B. Beyond extinction: Erasing human fear responses and preventing the return of fear. Nat Neurosci 2009; 12: 256-258.
7. Brunet A, Poundja J, Tremblay J, Bui E, Thomas E, Orr SP et al. Trauma reactivation under the influence of propranolol decreases posttraumatic stress symptoms and disorder: 3 open-label trials. J Clin Psychopharmacol 2011; 31: 547-550.
8. Monfils M-H, Cowansage KK, Klann E, LeDoux JE. Extinction-reconsolidation boundaries: Key to persistent attenuation of fear memories. Science 2009; 324: 951-955.
9. Schiller D, Monfils M-H, Raio CM, Johnson DC, Ledoux JE, Phelps E. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 2010; 463: 49-53.
10. American Psychiatry Association. Diagnostic and Statistical Manual of Mental Disorders (DSM IV), 4th edn. American Psychiatric Press: Washington DC, 1994.
11. Hettema JM, Annas P, Neale MC, Kendler KS, Fredrikson M. A twin study of the genetics of fear conditioning. Arch Gen Psychiatry 2003; 60: 702-708. (Pubitemid 36818632)
12. Crişan LG, Pana S, Vulturar R, Heilman RM, Szekely R, Druǧa B et al. Genetic contributions of the serotonin transporter to social learning of fear and economic decision making. Soc Cogn Affect Neurosci 2009; 4: 399-408.
13. Garpenstrand H, Annas P, Ekblom J, Oreland L, Fredrikson M. Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behav Neurosci 2001; 115: 358-364. (Pubitemid 32378165)
14. Lonsdorf TB, Weike AI, Nikamo P, Schalling M, Hamm AO, Ohman A. Genetic gating of human fear learning and extinction: Possible implications for gene-environment interaction in anxiety disorder. Psychol Sci 2009; 20: 198-206.
15. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531. (Pubitemid 26403928)
16. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-389. (Pubitemid 36877077)
17. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400-403. (Pubitemid 34790769)
18. LeDoux J. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 2003; 23: 727-738. (Pubitemid 37071496)
19. Fadok JP, Darvas M, Dickerson TMK, Palmiter RD. Long-term memory for pavlovian fear conditioning requires dopamine in the nucleus accumbens and basolateral amygdala. PloS ONE 2010; 5: E12751.
20. Mueller D, Bravo-Rivera C, Quirk GJ. Infralimbic D2 Receptors Are Necessary for Fear Extinction and Extinction-Related Tone Responses. Biol Psychiatry 2010; 68: 1055-1060.
21. LaLumiere RT, Nawar EM, McGaugh JL. Modulation of memory consolidation by the basolateral amygdala or nucleus accumbens shell requires concurrent dopamine receptor activation in both brain regions. Learn Mem 2005; 12: 296-301. (Pubitemid 40958340)
22. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 2004; 75: 807-821. (Pubitemid 39390488)
23. Raczka K, Mechias M-L, Gartmann N, Reif A, Deckert J, Pessiglione M et al. Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction. Translational Psychiatry 2011; 1: E12.
24. Boucsein W. Electrodermal activity. Plenum Press: New York, 1992.
25. Slifstein M, Kolachana B, Simpson EH, Tabares P, Cheng B, Duvall M et al. COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET. Mol Psychiatry 2008; 13: 821-827. (Pubitemid 352032110)
26. Johnson LC, Lubin A. On Planning Psychophysiological Experiments: Design, Measurement, and Analysis. In: Greenfield NS, Sternbach RA (eds). Handbook of Psychophysiology. Holt, Rinehart and Winston: New York, 1972, pp 125-153.
27. Lykken DT. Range correction applied to heart rate and to GSR data. Psychophysiology 1972; 9: 373-379.
28. Domschke K, Dannlowski U. Imaging genetics of anxiety disorders. Neuroimage 2010; 53: 822-831.
29. Bryant R, Felmingham KL, Falconer EM, Pe Benito L, Dobson-Stone C, Pierce KD et al. Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in posttraumatic stress disorder. Biol Psychiatry 2010; 67: 1217-1219.
30. Nordquist N, Oreland L. Serotonin, genetic variability, behaviour, and psychiatric disorders-a review. Ups J Med Sci 2010; 115: 2-10.
31. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski B, Munoz KE, Kolachana BS et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828-834. (Pubitemid 43085851)
32. Selvaraj S, Godlewska BR, Norbury R, Bose S, Turkheimer F, Stokes P et al. Decreased regional gray matter volume in S' allele carriers of the 5-HTTLPR triallelic polymorphism. Mol Psychiatry 2011; 16: 472-473.
33. Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P et al. The role of 5-HT(1A) receptors in learning and memory. Behav Brain Res 2008; 195: 54-77.
34. Foley AG, Murphy KJ, Hirst WD, Gallagher HC, Hagan JJ, Upton N et al. The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 2004; 29: 93-100. (Pubitemid 38068018)
35. Manuel-Apolinar L. 8-OH-DPAT facilitated memory consolidation and increased hippocampal and cortical cAMP production. Behav Brain Res 2004; 148: 179-184. (Pubitemid 37543666)
36. van Dyck CH, Malison RT, Staley JK, Jacobsen LK, Seibyl JP, Laruelle M et al. Measured With [123 I] b-CIT SPECT in Relation to Serotonin Transporter Genotype. Psychiatry: Interpersonal Biol Processes 2004; 161: 525-531.
37. Bah J, Lindström M, Westberg L, Mannerås L, Ryding E, Henningsson S et al. Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters. Psychiatry Res 2008; 162: 221-229.
38. Shioe K, Ichimiya T, Suhara T, Takano A, Sudo Y, Yasuno F et al. No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET. Synapse 2003; 48: 184-188. (Pubitemid 36520652)
39. Guo N, Hwang D-R, Lo E-S, Huang Y-Y, Laruelle M, Abi-Dargham A. Dopamine depletion and in vivo binding of PET D1 receptor radioligands: Implications for imaging studies in schizophrenia. Neuropsychopharmacology 2003; 28: 1703-1711. (Pubitemid 41070871)
40. Managó F, Castellano C, Oliverio A, Mele A, De Leonibus E. Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task. Learn Mem 2009; 16: 46-52.
41. Hikind N, Maroun M. Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning. Neurobiol Learn Mem 2008; 90: 217-222.
42. Hirvonen MM, Någren K, Rinne JO, Pesonen U, Vahlberg T, Hagelberg N et al. COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo. Mol Imaging Biol 2010; 12: 192-197.
43. Furmark T, Fischer H, Wik G, Larsson M, Fredrikson M. The amygdala and individual differences in human fear conditioning. Neuroreport 1997; 8: 3957-3960. (Pubitemid 28027216)
44. Etkin A, Wager TD. Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 2007; 164: 1476-1488. (Pubitemid 350069724)
45. Rasch B, Spalek K, Buholzer S, Luechinger R, Boesiger P, de Quervain DJ-F et al. Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype. Neuroimage 2010; 52: 1712-1719.
46. Williams LM, Gatt JM, Grieve SM, Dobson-Stone C, Paul RH, Gordon E et al. COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. Neuroimage 2010; 53: 918-925.
47. Lelli-Chiesa G, Kempton MJ, Jogia J, Tatarelli R, Girardi P, Powell J et al. The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives. Psychol Med 2011; 41: 779-788.
48. Domschke K, Ohrmann P, Braun M, Suslow T, Bauer J, Hohoff C et al. Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder. Psychiatry Res 2008; 163: 13-20.