Characterization of polysorbate 80 with liquid chromatography mass spectrometry and nuclear magnetic resonance spectroscopy: Specific determination of oxidation products of thermally oxidized polysorbate 80

Journal of Pharmaceutical and Biomedical Analysis

Volumn 62, Issue , 2012, Pages 7-16

  Hvattum, Erlend ^a   Yip, Wai Lam ^b   Grace, David ^a   Dyrstad, Knut ^a  

^a GE HEALTHCARE   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Degradation of polysorbate species; Fatty acid oxidation; LC ESI MS; NMR; Polysorbate 80

Indexed keywords

FATTY ACID; FATTY ACID ESTER; ISOSORBIDE; POLYOXYETHYLENE; POLYSORBATE 80; SORBITAN;

AIR TEMPERATURE; ARTICLE; ATMOSPHERE; DEGRADATION; ELECTROSPRAY MASS SPECTROMETRY; ESTERIFICATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT;

CHROMATOGRAPHY, LIQUID; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION-REDUCTION; POLYSORBATES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84857141437     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.12.009     Document Type: Article

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