Immunomodulatory properties of ES-62, a phosphorylcholine - containing glycoprotein secreted by Acanthocheilonema viteae

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 12, Issue 1, 2012, Pages 45-52

  Al Riyami, Lamyaa ^a   Harnett, William ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

ES 62; Filarial nematode; Immunomodulation; Signal transduction

Indexed keywords

ANTIINFLAMMATORY AGENT; B LYMPHOCYTE RECEPTOR; ES 62; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA; PHOSPHORYLCHOLINE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACANTHOCHEILONEMA VITEAE; ALLERGY; ANTIGEN BINDING; ANTIINFLAMMATORY ACTIVITY; ASTHMA; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DENDRITIC CELL; DOWN REGULATION; DRUG EFFICACY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FILARIA; GEL MOBILITY SHIFT ASSAY; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOGENICITY; IMMUNOMODULATION; MACROPHAGE; MAST CELL; MOLECULAR WEIGHT; NEMATODE LIFE CYCLE STAGE; NONHUMAN; OSMOTIC PUMP; PHENOTYPE; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 84857137289     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/187153012799278893     Document Type: Review

References (47)

1. th edn), McGraw-Hill, 2008.
2. Harnett, W.; McInnes, I.B. and Harnett M.M. (2004) ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential. Immunol. Lett., 94, 27-33.
3. Subramanian, S.; Stolk, W.A.; Ramaiah, K.D.; Plaisier, A.P.; Krishnamoorthy, K.; Van Oortmarssen, G.J.; Dominic Amalraj, D.; Habbema, J.D. and Das, P.K. (2004) The dynamics of Wuchereria bancrofti infection: a model-based analysis of longitudinal data from Pondicherry, India. Parasitology, 128, 467-482.
4. Harnett, W. and Parkhouse, R.M.E. Nature and function of parasitic nematode surface and excretory-secretory antigens. In: Sood MI, Kapur J, Eds. (1995) Perspectives in Nematode Physiology and Biochemistry. New Delhi: Narendra Publication House, pp. 207-242.
5. Harnett, W.; Grainger, M.; Kapil, A.; Worms, M.J. and Parkhouse, R.E.M. (1989) Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae. Parasitology, 99, 229-239.
6. Stepek, G.; Auchie, M.; Tate, R.; Watson, K.; Russel, D.G.; Devaney, E. and Harnett, W. (2002) Expression of the filarial nematode phosphorycholine-containing glycoprotein, ES-62, is stage specific. Parasitology, 125, 155-164.
7. Stepek, G.; Houston, K.M.; Goodridge, H.S.; Devaney, E. and Harnett, W. (2004) Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62. Parasitology, 128, 91-98.
8. Harnett, W.; Goodridge, H.S. and Harnett, M.M. (2005) Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62. Parasitol., 130, 63-68.
9. Nor, Z.M.; Devaney, E. and Harnett, W. (1997) The use of inhibitors of N-linked glycosylation and oligosaccharide processing to produce monoclonal antibodies against non-phosphorylcholine epitopes of Brugia pahangi excretory-secretory products. Parasitology Res., 83, 813-815.
10. Harnett, W.; Harnett, M.M. and Byron, O. (2003) Structural/functional aspects of ES-62-A secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein. Curr. Protein Pept. Sci., 4, 59-71.
11. Harnett, W.; Houston, K.M.; Amess, R. and Worms, M.J. (1993) Acanthocheilonema viteae: phosphorylcholine is attached to the major excretory-secretory product via an N-linked glycan. Experim. Parasitol., 77, 498-502.
12. Houston, K.M. and Harnett, W. (1996) Prevention of attachment of phosphorylcholine to a major excretory-secretory product of Acanthocheilonema viteae using tunicamycin. J. Parasitol., 82, 320-324.
13. Houston, K.M.; Cushley, W. and Harnett, W. (1997) Studies on the site and mechanisms of attachment of phosphorylcholine to a filarial nematode secreted glycoprotein. J. Biol. Chem., 272, 1527-1533.
14. Haslam, S.M.; Khoo, K.H.; Houston, K.M.; Harnett, W.; Morris, H.R. and Dell, A. (1997) Characterisation of the phosphorylcholinecontaining N-linked oligosaccharides in the excretory-secretory 62kDa glycoprotein of Acanthocheilonema viteae. Mol. Biochem. Parasitol., 85, 53-66.
15. Harnett, W. and Harnett, M. (1999) Phosphorylcholine: friend or foe of the immune response? Immunol. Today, 20, 125-129.
16. Harnett, W.; Deehan, M.R.; Houston, K. and Harnett, M.M. (1999) Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein. Parasite Immunol., 21, 601-608.
17. Houston, K.M.; Wilson, E.H.; Eyres, L.; Brombacher, F.; Harnett, M.M.; Alexander, J. and Harnett, W. (2000) Presence of phosphorylcholine on a filarial nematode protein influences immunoglobulin G subclass response to the molecule by an interleukin-10- dependent mechanism. Infect. Immun., 68, 5466-5468.
18. Harnett, W. and Harnett, M.M. (1993) Inhibition of murine B cell proliferation and down-regulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product. J. Immunol., 151, 4829-4837.
19. Wilson, E.H.; Katz, E.; Goodridge, H.S.; Harnett, M.M. and Harnett, W. (2003) In vivo activation of murine B1 cells by filarial nematode phosphorylcholine-containing glycoprotein ES-62. Parasite Immunol., 25, 463-466
20. Deehan, M.R.; Harnett, W. and Harnett, M.M. (2001) A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signalregulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology 2 domaincontaining tyrosine phosphatase-1 and Pac-1 mitogen-activated kinase-phosphatase. J. Immunol., 166, 7462-7468.
21. Kurosaki, T.; Shinohara, H. and Baba. Y. (2010) B cell signaling and fate decision. Annu. Rev. Immunol., 28, 21-55.
22. Dal Porto, J.M.; Gauld, S.B.; Merrell, K.T.; Mills, D.; Pugh-Bernard, A.E. and Cambier, J. (2004) B cell antigen signalling 101. Mol. Immunol., 41, 599-613.
23. Deehan, M.R.; Frame, M.J.; Parkhouse, R.M.; Seatter, S.D.; Reid, S.D.; Harnett, M.M. and Harnett, W. (1998) A phosphorylcholine-containing filarial nematode-secreted product disrupts B lymphocyte activation by targeting key proliferative signalling pathways. J. Immunol., 160, 2692-2699.
24. Deehan, M.R.; Harnett, M.M. and Harnett, W. (1997) A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes. J. Immunol., 159, 6105-6111.
25. Harnett, W. and Harnett, M.M. (2008). Lymphocyte hyporesponsiveness during filarial nematode infection. Parasite Immunol., 30, 447-453.
26. Harnett, M.M.; Deehan, M.R.; Williams, D.S. and Harnett, W. (1998) Induction of signalling via the TCR in Jurkat T cells by preexposure to a filarial nematode secreted product. Parasite Immunol., 20, 551-564.
27. Lal, R.B.; Kumaraswami, V.; Steel, C. and Nutman, T.B. (1990) Phosphocholine-containing. antigens. of. Brugia. malayi nonspecifically suppress lymphocyte function. Am. J. Trop. Med. Hyg., 42, 56-64.
28. Marshall, F.A.; Grierson, A.M.; Garside, P.; Harnett, W. and Harnett, M.M. (2005) ES-62, an immunomodulatory secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo. J. Immunol., 175, 5817-5826.
29. Marshall, F.A.; Watson, K.A.; Garside, P.; Harnett, M.M. and Harnett, W. (2007) Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo. Immunology, 123, 411-425.
30. Kou, P.M. and Babensee J.E. (2010) Macrophage and dendritic cell phenotypic diversity in the context of biomaterials. J. Biomed. Mater. Res. A., 96, 239-260.
31. Goodridge, H.S.; Wilson, E.H.; Campbell, C.; Harnett, M.M. and Liew, F.T. (2001) Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. J. Immunol., 167, 940-945.
32. Babu, S. and Nutman, T.B. (2003) Pro-inflammatory cytokines dominate the early immune response to filarial parasites. J. Immunol., 171, 6723-6732.
33. Goodridge, H.S.; Marshall, F.A.; Else, K.J.; Houston, K.M.; Egan, C.; Al-Riyami, L.; Liew, F.Y.; Harnett, W. and Harnett, M. (2005) Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J. Immunol., 174, 284-293.
34. Takeda. K.; Kaisho, T. and Akira, S. (2003) Toll-like receptors. Annu. Rev. Immunol., 21, 335-376.
35. Goodridge, H.S.; Harnett, W.; Liew, F.Y. and Harnett, M.M. (2003) Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and - independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology, 109, 415-425.
36. Goodridge, H.S.; Stepek, G.; Harnett, W. and Harnett, M.M. (2005) Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology, 115, 296-304.
37. Galli, S.J.; Grimbaldeston, M. and Tsai, M. (2008) Immuno-modulatory mast cells: negative, as well as positive, regulators of immunity. Nat. Rev. Immunol., 8, 478-486.
38. Melendez, A.J.; Harnett, M.M.; Pushparaj, P.N.; Wong, W.S.; Tay, H.K.; McSharry, C.P. and Harnett, W. (2007) Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nat. Med., 13, 1375-1381.
39. Klareskog, L.; Catrina, A.I. and Paget, S. (2009) Rheumatoid arthritis. Lancet, 373, 659-672.
40. McInnes, I.B. and Schett, G. (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol., 7, 429-442.
41. McInnes, I.B.; Leung, B.P.; Harnett, M.; Gracie, J.A.; Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. J. Immunol., 171, 2127-2133.
42. Harnett, M.M.; Kean, D.E.; Boitelle, A.; McGuiness, S.; Thalhamer, T.; Steiger, C.N.; Egan, C.; Al-Riyami, L.; Alcocer, M.J.; Houston, K.M.; Gracie, J.A.; McInnes, I.B. and Harnett, W. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Ann. Rheum. Dis., 67, 518-523.
43. Couper, K.N.; Chen, W.; Houston, K.M.; Harnett, W. and Johnson, L.L. (2005) ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology. Parasite Immunol., 27, 147-150.
44. Al-Riyami, L.; Egan, C.A.; Bradley, J.E.; Lustigman, S. and Harnett, W. (2008) Failure of ES-62 to inhibit T-helper type 1 responses to other filarial nematode antigens. Parasite Immunol., 30, 304-308.
45. Al-Riyami, L.; Wilson, E.H.; Watson, C.A. and Harnett, W. (2009) T-helper type 1 responses to the BCG vaccine component PPD in mice are unaffected by the filarial nematode immunomodulatory molecule ES-62. J. Parasitol., 95, 1201-1204.
46. Harnett, W. and Harnett, M.M. (2008) Therapeutic immuno-modulators from nematode parasites. Expert. Rev. Mol. Med., 10, e18.
47. Houston, K.M. and Harnett, W. (2004) Structure and synthesis of nematode phosphorylcholine-containing glycoconjugates. Parasitology, 129, 655-661.