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Volumn 94, Issue 1-2, 2004, Pages 27-33

ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential

Author keywords

bovine serum albumin; BSA; CIA; CII; collagen induced arthritis; ConA; concanavalin A; FABMS; fast atom bombardment mass spectroscopy; GlcNAc; IFN; Il; interferon; interleukin; intraperitoneal; ip; lipopolysaccharide; LPS; N acetyl glucosamine; PC; type II collagen

Indexed keywords

ANTIINFLAMMATORY AGENT; ES 62; IMMUNOMODULATING AGENT; UNCLASSIFIED DRUG;

EID: 3242728394     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2004.04.008     Document Type: Review
Times cited : (56)

References (57)
  • 1
    • 0004948701 scopus 로고
    • Geneva: World Health Organisation;
    • WHO. Filariasis. Geneva: World Health Organisation; 1987.
    • (1987) Filariasis
  • 4
    • 0025820720 scopus 로고
    • Immunological tolerance: The key feature in human filariasis?
    • Maizels R.M., Lawrence R.A. Immunological tolerance: the key feature in human filariasis? Parasitol. Today. 7:1991;271-276
    • (1991) Parasitol. Today , vol.7 , pp. 271-276
    • Maizels, R.M.1    Lawrence, R.A.2
  • 5
    • 0024746127 scopus 로고
    • Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae
    • Harnett W., Grainger M., Kapil A., Worms M.J., Parkhouse R.M.E. Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae. Parasitol. Today. 99:1989;229-239
    • (1989) Parasitol. Today , vol.99 , pp. 229-239
    • Harnett, W.1    Grainger, M.2    Kapil, A.3    Worms, M.J.4    Parkhouse, R.M.E.5
  • 6
    • 0027137177 scopus 로고
    • Acanthocheilonema viteae: Phosphorylcholine is attached to the major excretory-secretory product via an N-linked glycan
    • Harnett W., Houston K.M., Amess R., Worms M.J. Acanthocheilonema viteae: phosphorylcholine is attached to the major excretory-secretory product via an N-linked glycan. Exp. Parasitol. 77:1993;498-502
    • (1993) Exp. Parasitol. , vol.77 , pp. 498-502
    • Harnett, W.1    Houston, K.M.2    Amess, R.3    Worms, M.J.4
  • 8
    • 0030895871 scopus 로고    scopus 로고
    • Variation in the nature of attachment of phosphorylcholine to excretory-secretory products of adult Brugia pahangi
    • Nor Z.M., Houston K.M., Devaney E., Harnett W. Variation in the nature of attachment of phosphorylcholine to excretory-secretory products of adult Brugia pahangi. Parasitol. Today. 114:1997;257-262
    • (1997) Parasitol. Today , vol.114 , pp. 257-262
    • Nor, Z.M.1    Houston, K.M.2    Devaney, E.3    Harnett, W.4
  • 9
    • 0036668170 scopus 로고    scopus 로고
    • Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES-62, is stage-specific
    • Stepek G., Auchie M., Tate R., Watson K., Russell D.G., Devaney E., Harnett W. Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES-62, is stage-specific. Parasitol. Today. 125:2002;155-164
    • (2002) Parasitol. Today , vol.125 , pp. 155-164
    • Stepek, G.1    Auchie, M.2    Tate, R.3    Watson, K.4    Russell, D.G.5    Devaney, E.6    Harnett, W.7
  • 10
    • 0348100953 scopus 로고    scopus 로고
    • Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62
    • Stepek G., Houston K.M., Goodridge H.S., Devaney E., Harnett W. Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62. Parasitol. Today. 128:2004;91-98
    • (2004) Parasitol. Today , vol.128 , pp. 91-98
    • Stepek, G.1    Houston, K.M.2    Goodridge, H.S.3    Devaney, E.4    Harnett, W.5
  • 12
    • 0030989415 scopus 로고    scopus 로고
    • Characterisation of the phosphorylcholine-containing N-linked oligosaccharides in the excretory-secretory 62 kDa glycoprotein of Acanthocheilonema viteae
    • Haslam S.M., Khoo K.H., Houston K.M., Harnett W., Morris H.R., Dell A. Characterisation of the phosphorylcholine-containing N-linked oligosaccharides in the excretory-secretory 62 kDa glycoprotein of Acanthocheilonema viteae. Mol. Biochem. Parasitol. 85:1997;53-66
    • (1997) Mol. Biochem. Parasitol. , vol.85 , pp. 53-66
    • Haslam, S.M.1    Khoo, K.H.2    Houston, K.M.3    Harnett, W.4    Morris, H.R.5    Dell, A.6
  • 13
    • 0033426133 scopus 로고    scopus 로고
    • Attachment of phosphorylcholine to a nematode glycoprotein
    • Houston K.M., Harnett W. Attachment of phosphorylcholine to a nematode glycoprotein. Trends Glycosci. Glycotechnol. 11:1999;43-52
    • (1999) Trends Glycosci. Glycotechnol. , vol.11 , pp. 43-52
    • Houston, K.M.1    Harnett, W.2
  • 14
    • 0025606055 scopus 로고
    • Association between circulating antigen and parasite load in a model filarial system, Acanthocheilonema viteae in jirds
    • Harnett W., Worms M.J., Grainger M., Pyke S.D.M., Parkhouse R.M.E. Association between circulating antigen and parasite load in a model filarial system, Acanthocheilonema viteae in jirds. Parasitol. Today. 101:1990;435-444
    • (1990) Parasitol. Today , vol.101 , pp. 435-444
    • Harnett, W.1    Worms, M.J.2    Grainger, M.3    Pyke, S.D.M.4    Parkhouse, R.M.E.5
  • 15
    • 0002534712 scopus 로고
    • Structure and function of nematode surface and excretory-secretory products
    • Sood ML, editor. New Delhi: M/S Narendra Publication House;
    • Harnett W, Parkhouse RME. Structure and function of nematode surface and excretory-secretory products. In: Sood ML, editor. Perspectives in nematode physiology and biochemistry. New Delhi: M/S Narendra Publication House; 1995. p. 207-42.
    • (1995) Perspectives in Nematode Physiology and Biochemistry , pp. 207-242
    • Harnett, W.1    Parkhouse, R.M.E.2
  • 16
    • 0034213669 scopus 로고    scopus 로고
    • Phosphocholine-containing, zwitterionic glycosphingolipids of adult Onchocerca volvulus as highly conserved antigenic structures of parasitic nematodes
    • Wuhrer M., Rickhoff S., Dennis R.D., Lochnit G., Soboslay P.T., Baumeister S., Geyer R. Phosphocholine-containing, zwitterionic glycosphingolipids of adult Onchocerca volvulus as highly conserved antigenic structures of parasitic nematodes. Biochem. J. 348:2000;417-423
    • (2000) Biochem. J. , vol.348 , pp. 417-423
    • Wuhrer, M.1    Rickhoff, S.2    Dennis, R.D.3    Lochnit, G.4    Soboslay, P.T.5    Baumeister, S.6    Geyer, R.7
  • 17
    • 0033597847 scopus 로고    scopus 로고
    • Structural studies of phosphocholine-substituted N-glycans of filarial parasites: Conservation amongst species and discovery of novel chito-oligomers
    • Haslam S.M., Houston K.M., Harnett W., Reason A.J., Morris H.R., Dell A. Structural studies of phosphocholine-substituted N-glycans of filarial parasites: conservation amongst species and discovery of novel chito-oligomers. J. Biol. Chem. 274:1999;20953-20960
    • (1999) J. Biol. Chem. , vol.274 , pp. 20953-20960
    • Haslam, S.M.1    Houston, K.M.2    Harnett, W.3    Reason, A.J.4    Morris, H.R.5    Dell, A.6
  • 18
    • 0037302799 scopus 로고    scopus 로고
    • Structural/Functional aspects of ES-62 - A secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein
    • Harnett W., Harnett M.M., Byron O. Structural/Functional aspects of ES-62 - a secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein. Curr. Protein Peptide Sci. 4:2003;59-72
    • (2003) Curr. Protein Peptide Sci. , vol.4 , pp. 59-72
    • Harnett, W.1    Harnett, M.M.2    Byron, O.3
  • 19
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain S.L., Weinberg A.D., English M., Huston G. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:1990;3796-3806
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 20
    • 0032761107 scopus 로고    scopus 로고
    • Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein
    • Harnett W., Deehan M.D., Houston K.M., Harnett M.M. Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein. Parasite Immunol. 21:1999;601-608
    • (1999) Parasite Immunol. , vol.21 , pp. 601-608
    • Harnett, W.1    Deehan, M.D.2    Houston, K.M.3    Harnett, M.M.4
  • 21
    • 0034660408 scopus 로고    scopus 로고
    • A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells
    • Whelan M., Harnett M.M., Houston K.M., Patel V., Harnett W., Rigley K.P. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J. Immunol. 164:2000;6453-6460
    • (2000) J. Immunol. , vol.164 , pp. 6453-6460
    • Whelan, M.1    Harnett, M.M.2    Houston, K.M.3    Patel, V.4    Harnett, W.5    Rigley, K.P.6
  • 22
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245-252
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 23
    • 0027336689 scopus 로고
    • Development of Th1 CD+ T cells through IL-12 produced by Listeria-induced macrophages
    • Hsieh C.-S., Macatonia S.E., Tripp C.S., Wolf S.F., O'Garra A., Murphy K.M. Development of Th1 CD+ T cells through IL-12 produced by Listeria-induced macrophages. Science. 260:1993;547-549
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.-S.1    MacAtonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O'Garra, A.5    Murphy, K.M.6
  • 24
    • 0035879221 scopus 로고    scopus 로고
    • Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae
    • Goodridge H.S., Wilson E.H., Harnett W., Campbell C.C., Harnett M.M., Liew F.Y. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. J. Immunol. 167:2001;940-945
    • (2001) J. Immunol. , vol.167 , pp. 940-945
    • Goodridge, H.S.1    Wilson, E.H.2    Harnett, W.3    Campbell, C.C.4    Harnett, M.M.5    Liew, F.Y.6
  • 25
    • 0020520837 scopus 로고
    • Binding of phosphorylcholine by non-immunoglobulin molecules on mouse B cells
    • Bach M.A., Kohler H., Levitt D. Binding of phosphorylcholine by non-immunoglobulin molecules on mouse B cells. J. Immunol. 131:1983;365-371
    • (1983) J. Immunol. , vol.131 , pp. 365-371
    • Bach, M.A.1    Kohler, H.2    Levitt, D.3
  • 26
    • 0021358615 scopus 로고
    • Phosphorylcholine on Streptococcus pneumoniae R36a is responsible for in vitro polyclonal antibody secretion by human peripheral blood lymphocytes
    • Beckmann E., Levitt D. Phosphorylcholine on Streptococcus pneumoniae R36a is responsible for in vitro polyclonal antibody secretion by human peripheral blood lymphocytes. J. Immunol. 132:1984;2174-2176
    • (1984) J. Immunol. , vol.132 , pp. 2174-2176
    • Beckmann, E.1    Levitt, D.2
  • 27
    • 0027505088 scopus 로고
    • Inhibition of murine B cell proliferation and down-regulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product
    • Harnett W., Harnett M.M. Inhibition of murine B cell proliferation and down-regulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product. J. Immunol. 151:1993;4829-4837
    • (1993) J. Immunol. , vol.151 , pp. 4829-4837
    • Harnett, W.1    Harnett, M.M.2
  • 28
    • 0023214867 scopus 로고
    • Circulating parasite antigen(s) in lymphatic filariasis - Use of monoclonal-antibodies to phosphocholine for immunodiagnosis
    • Lal R.B., Paranjape R.S., Briles D.E., Nutman T.B., Ottesen E.A. Circulating parasite antigen(s) in lymphatic filariasis - use of monoclonal-antibodies to phosphocholine for immunodiagnosis. J. Immunol. 138:1987;3454-3460
    • (1987) J. Immunol. , vol.138 , pp. 3454-3460
    • Lal, R.B.1    Paranjape, R.S.2    Briles, D.E.3    Nutman, T.B.4    Ottesen, E.A.5
  • 30
    • 0035224933 scopus 로고    scopus 로고
    • Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode
    • Harnett M.M., Harnett W. Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode. Arch. Immunol. Ther. Exp. (Warsz). 49:2001;263-269
    • (2001) Arch. Immunol. Ther. Exp. (Warsz) , vol.49 , pp. 263-269
    • Harnett, M.M.1    Harnett, W.2
  • 31
    • 0030639673 scopus 로고    scopus 로고
    • B-1 cell (CD5+B220+) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polylactosamine sugars
    • Velupillai P., Secor W.E., Horauf A.M., Harn D.A. B-1 cell (CD5+B220+) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polylactosamine sugars. J. Immunol. 158:1997;338-344
    • (1997) J. Immunol. , vol.158 , pp. 338-344
    • Velupillai, P.1    Secor, W.E.2    Horauf, A.M.3    Harn, D.A.4
  • 32
    • 0031974840 scopus 로고    scopus 로고
    • The Xid defect imparts susceptibility to experimental murine filariosis - Association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine
    • AlQaoud K.M., Fleischer B., Hoerauf A. The Xid defect imparts susceptibility to experimental murine filariosis - association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine. Int. Immunol. 10:1998;17-25
    • (1998) Int. Immunol. , vol.10 , pp. 17-25
    • Alqaoud, K.M.1    Fleischer, B.2    Hoerauf, A.3
  • 33
    • 0346095279 scopus 로고    scopus 로고
    • In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62
    • Wilson E.H., Katz E., Goodridge H.S., Harnett M., Harnett W. In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62. Parasite Immunol. 25:2003;463-466
    • (2003) Parasite Immunol. , vol.25 , pp. 463-466
    • Wilson, E.H.1    Katz, E.2    Goodridge, H.S.3    Harnett, M.4    Harnett, W.5
  • 34
    • 0023749983 scopus 로고
    • Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes
    • Mercolino T.J., Arnold L.W., Hawkins L.A., Haughton G. Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes. J. Exp. Med. 168:1988;687-698
    • (1988) J. Exp. Med. , vol.168 , pp. 687-698
    • Mercolino, T.J.1    Arnold, L.W.2    Hawkins, L.A.3    Haughton, G.4
  • 36
    • 0035000364 scopus 로고    scopus 로고
    • Human bancroftian filariasis - A role for antibodies to parasite carbohydrates
    • Mohanty M.C., Satapathy A.K., Sahoo P.K., Ravindran B. Human bancroftian filariasis - a role for antibodies to parasite carbohydrates. Clin. Exp. Immunol. 124:2001;54-61
    • (2001) Clin. Exp. Immunol. , vol.124 , pp. 54-61
    • Mohanty, M.C.1    Satapathy, A.K.2    Sahoo, P.K.3    Ravindran, B.4
  • 38
    • 0031573557 scopus 로고    scopus 로고
    • A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes
    • Deehan M., Harnett M., Harnett W. A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes. J. Immunol. 159:1997;6105-6111
    • (1997) J. Immunol. , vol.159 , pp. 6105-6111
    • Deehan, M.1    Harnett, M.2    Harnett, W.3
  • 40
    • 0033857664 scopus 로고    scopus 로고
    • The presence of phosphorylcholine on a filarial nematode protein influences the IgG subclass response to a molecule and by a mechanism dependent on IL-10
    • Houston K., Wilson E.H., Eyres L., Brombacher F., Harnett M.M., Alexander J., Harnett W. The presence of phosphorylcholine on a filarial nematode protein influences the IgG subclass response to a molecule and by a mechanism dependent on IL-10. Infect. Immun. 68:2000;5466-5468
    • (2000) Infect. Immun. , vol.68 , pp. 5466-5468
    • Houston, K.1    Wilson, E.H.2    Eyres, L.3    Brombacher, F.4    Harnett, M.M.5    Alexander, J.6    Harnett, W.7
  • 41
    • 0030298467 scopus 로고    scopus 로고
    • B-cell outgrowth and ligand-specific production of IL-10 correlate with TH2 dominance in certain parasitic diseases
    • Palanivel V., Posey C., Horauf A.M., Solbach W., Piessens W.F., Harn D.A. B-cell outgrowth and ligand-specific production of IL-10 correlate with TH2 dominance in certain parasitic diseases. Exp. Parasitol. 84:1996;168-177
    • (1996) Exp. Parasitol. , vol.84 , pp. 168-177
    • Palanivel, V.1    Posey, C.2    Horauf, A.M.3    Solbach, W.4    Piessens, W.F.5    Harn, D.A.6
  • 42
    • 0026457998 scopus 로고
    • Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10
    • Bogdan C., Paik J., Vodovotz Y., Nathan C. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. J. Biol. Chem. 267:1992;23301-23308
    • (1992) J. Biol. Chem. , vol.267 , pp. 23301-23308
    • Bogdan, C.1    Paik, J.2    Vodovotz, Y.3    Nathan, C.4
  • 43
    • 0037013751 scopus 로고    scopus 로고
    • Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections
    • Sewell D.L., Reinke E.K., Hogan L.H., Sandor M., Fabry Z. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. Immunol. Lett. 82:2002;101-110
    • (2002) Immunol. Lett. , vol.82 , pp. 101-110
    • Sewell, D.L.1    Reinke, E.K.2    Hogan, L.H.3    Sandor, M.4    Fabry, Z.5
  • 44
    • 0016741329 scopus 로고
    • Rheumatoid arthritis in a rural South African Negro population
    • Beighton P., Solomon L., Valkenburg H.A. Rheumatoid arthritis in a rural South African Negro population. Ann. Rheum. Dis. 34:1975;136-141
    • (1975) Ann. Rheum. Dis. , vol.34 , pp. 136-141
    • Beighton, P.1    Solomon, L.2    Valkenburg, H.A.3
  • 47
    • 0344157333 scopus 로고    scopus 로고
    • Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: Enhanced activity in synovial fluid compared to blood
    • Ronnelid J., Berg L., Rogberg S., Nilsson A., Albertsson K., Klareskog L. Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: enhanced activity in synovial fluid compared to blood. Br. J. Rheumatol. 37:1998;7-14
    • (1998) Br. J. Rheumatol. , vol.37 , pp. 7-14
    • Ronnelid, J.1    Berg, L.2    Rogberg, S.3    Nilsson, A.4    Albertsson, K.5    Klareskog, L.6
  • 50
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud M., Durand J.M., Buchs N., Fossiez F., Page G., Frappart L., Miossec P. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 42:1999;963-970
    • (1999) Arthritis Rheum. , vol.42 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3    Fossiez, F.4    Page, G.5    Frappart, L.6    Miossec, P.7
  • 52
    • 0042134781 scopus 로고    scopus 로고
    • A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62
    • McInnes I.B., Leung B., Harnett M.M., Gracie J.A., Liew F.Y., Harnett W. A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. J. Immunol. 171:2003;2127-2133
    • (2003) J. Immunol. , vol.171 , pp. 2127-2133
    • McInnes, I.B.1    Leung, B.2    Harnett, M.M.3    Gracie, J.A.4    Liew, F.Y.5    Harnett, W.6
  • 53
    • 0026644298 scopus 로고
    • Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis
    • Williams R.O., Feldmann M., Maini R.N. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A. 89:1992;9784-9788
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 9784-9788
    • Williams, R.O.1    Feldmann, M.2    Maini, R.N.3
  • 54
    • 0031042456 scopus 로고    scopus 로고
    • Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
    • McInnes I.B., Leung B.P., Sturrock R.D., Field M., Liew F.Y. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat. Med. 3:1997;189-195
    • (1997) Nat. Med. , vol.3 , pp. 189-195
    • McInnes, I.B.1    Leung, B.P.2    Sturrock, R.D.3    Field, M.4    Liew, F.Y.5
  • 55
    • 0034469236 scopus 로고    scopus 로고
    • Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells
    • McInnes I.B., Leung B.P., Liew F.Y. Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells. Arthritis Res. 2:2000;374-378
    • (2000) Arthritis Res. , vol.2 , pp. 374-378
    • McInnes, I.B.1    Leung, B.P.2    Liew, F.Y.3
  • 56
    • 0036164274 scopus 로고    scopus 로고
    • Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis
    • Brennan F.M., Hayes A.L., Ciesielski C.J., Green P., Foxwell B.M., Feldmann M. Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis. Arthritis Rheum. 46:2002;31-41
    • (2002) Arthritis Rheum. , vol.46 , pp. 31-41
    • Brennan, F.M.1    Hayes, A.L.2    Ciesielski, C.J.3    Green, P.4    Foxwell, B.M.5    Feldmann, M.6
  • 57
    • 0033281731 scopus 로고    scopus 로고
    • Cytokines and direct cell contact in synovitis: Relevance to therapeutic intervention
    • Dayer J.M., Burger D. Cytokines and direct cell contact in synovitis: relevance to therapeutic intervention. Arthritis Res. 1:1999;17-20
    • (1999) Arthritis Res. , vol.1 , pp. 17-20
    • Dayer, J.M.1    Burger, D.2


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