Induction of signalling anergy via the T-cell receptor in cultured Jurkat T cells by pre-exposure to a filarial nematode secreted product

Parasite Immunology

Volumn 20, Issue 11, 1998, Pages 551-563

  Harnett, Margaret M ^a   Deehan, Maureen R ^b   Williams, Denise M ^a   Harnett, William ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Anergy; Filariasis; Helminth; Signal transduction; T cells

Indexed keywords

GLYCOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE D; PHOSPHORYLCHOLINE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CLONAL ANERGY; FILARIA; FILARIASIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACANTHOCHEILONEMA VITEAE; FILARIA; NEMATODA; RODENTIA; VERMES;

EID: 0031744129     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1998.00181.x     Document Type: Article

References (48)

1. Aleppo G., Nicoletti F., Sortino M.A. et al. (1994) Chronic L-alpha-glyceryl-phosphorylcholine increases inositol phosphate formation in brain slices and neuronal cultures. Pharmacology and Toxicology 74, 95-100
2. Bradley J.E. & Unnasch T.R. (1996) Molecular approaches to the diagnosis of onchocerciasis. Advances in Parasitology 37, 57-106
3. Cook S.J. & Wakelam M.J.O. (1992) Phospholipases C and D in mitogenic signal transduction. Reviews of Physiology and Pharmacology 119, 13-45
4. Cuadrado A., Carnero A., Dolfi F. et al. (1993) Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene 8, 2959-2968
5. Cundell D.R., Gerard N.P., Gerard C. et al. (1995) Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 377, 435-438
6. Deehan M.R., Frame M.J., Parkhouse R.M.E. et al. (1998) A phosphorylcholine-containing filarial nematode secreted products disrupts B lymphocyte activation by targeting key proliferative signalling pathways. Journal of Immunology 160, 2692-2699
7. Deehan M.R., Harnett M.M. & Harnett W. (1997) A filarial Nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes. Journal of Immunology 159 (12), 6105-6111
8. Dekker L.V. & Parker P.J. (1994) Protein kinase C-a question of specificity. TIBS 19, 73-77
9. Desai N.N., Carlson R.O., Mattie M.E. et al. (1993) Signalling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. Journal of Cell Biology 121, 1385-1396
10. Divecha N. & Irvine R.F. (1995) Phospholipid signalling. Cell 80, 269-278
11. 2+ exchanger in macrophages and in lymphocytes? Pflugers Archiv. European Journal of Physiology 424, 448-455
12. Franklin R.A., Mazer B., Sawami H. et al. (1993) Platelet-activating factor triggers the phosphlorylation and activation of MAP-2 kinase and S6 peptide kinase activity in human B cell lines. Journal of Immunology 151, 1802-1810
13. 2 correlate with lymphocyte maturation. Journal of Immunology 156, 2054-2062
14. Gilbert J.J., Wakelam M.J.O. & Harnett M.M. (1993) A role for phospholipase D activation in B cell activation. Biochemical Society Transactions 21, 493
15. Harnett M.M. & Klaus G.G.B. (1998) G protein coupling of antigen receptor stimulated polyphosphoinositide hydrolysis in B cell. Journal of Immunology 140, 3135
16. Harnett W., Grainger M., Kapil A. et al. (1989) Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae. Parasitology 99, 229-239
17. Harnett, W. & Harnett MM. (1993) Inhibition of murine B cell proliferation and down-regulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product Journal of Immunology 151, 4829-4837
18. Harnett W., Houston K.M., Amess R et al. (1993) Acanthocheilonema vateae: phosphorylcholine is attached to the major excretory-secretory product via an N-linked glycan. Experimental Parasitology 77, 498-502
19. Hug H. & Sarre T.F. (1993) Protein kinase C isoenzymes:divergence in signal transduction? Biochemical Journal 291, 329-343
20. Izquierdo M., Leevers S.J., Marshall C.J. et al. (1993) p21ras couples the T cell antigen receptor to extracellular signal-related kinase 2 in T lymphocytes. Journal of Experimental Medicine 178, 1199
21. Jiminez B., del Peso L., Montaner S. et al. (1995) Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-Kinases in growth factors-induced mitogenic stimulation. Journal of Cell Biochemistry 57, 141-149
22. Kazura J.W., Nutman T.B. & Green B, eds. (1993) Filariasis. In: Immunology and Molecular Biology of Parasitic Infections. Third edn, K.S. Warren ed. Blackwell Scientific Publications, Oxford
23. Lal, R.B., Kumaraswami V., Steel C. et al. (1990) Phosphorylcholine-containing antigens of Brugia malayi non-specificaly suppress lymphocyte function. American Journal of Tropical Medicine and Hygiene 42(1), 56-64
24. Lammie P.J., Katz S.P. & Anderson W.H.K. (1984) Serosuppression in experimental filariasis Clinical and Experimental Immunology 55, 602-610
25. Liscovitch M. (1992) Crosstalk among multiple signal activated lipases. Trends in Biochemical Science 17, 393-399
26. Liscovitch M. & Cantley L.C. (1994) Lipid second messengers. Cell 77, 329-334
27. Maizels R.M. & Lawrence R.A. (1991) Immunological tolerance: the key feature in human filariasis? Parasitology Today 7, 271-276
28. 4 responsiveness in a subpopulation of microfilaremic persons. Journal of Infectious Diseases 172, 1630-1633
29. Mazer B., Domenico J., Sawami H. et al. (1991) Platelet-activating factor induces an increase in intracellular calcium and expression of regulatory genes in human B lymphoblastoid cells. Journal of Immunology 146, 1914-1920
30. Michie A.M., Lobban M.D., Muller T. et al. (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cellular Signalling 8, 97-110
31. Mitchell G.F. & Lewers H.M. (1976) Studies on immune responses to parasite antigens in mice IV. Inhibition of an anti-DNP antibody response with antigen, DNP-Ficoll containing phosphorylcholine. International Archives of Allergy and Applied Immunology 52, 235
32. Mollinedo F., Gajate C. & Flores I. (1994) Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells. Journal of Immunology 153, 2457-2461
33. Ottesen E.A. (1995) Immune responsiveness and the pathogenesis of human onchocerciasis. Journal of Infectious Diseases 171, 659-671
34. Piessens W.F., Ratiwayanto S., Tuti S. et al. (1980) Antigen-specific suppressor cells and suppressor factors in human filariasis with Brugia malayi. New England Journal of Medicine 302, 833-839
35. Qiu R., Melmon K.L. & Khan M.M. (1993) Cyclic AMP is not a direct regulator of calcium flux and hydrolysis of phosphoinositides in human lymphocytes. Immunopharmacology 25, 37-49
36. Reid P.A., Gardner S.D., Williams D.M. et al. (1997) The antigen receptors on mature and immature T lymphocytes are coupled to phosphatidylcholine-specific phospholipase D activation. Immunology 90, 250-256
37. Rodriguez-Viciana P., Warne P.H., Dhang R. et al. (1904) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532
38. Sartono E., Kruize Y.C.M., Partono F. et al. (1995) Specific T cell unresponsiveness in human filariasis: diversity in underlying mechanisms. Parasite Immunology 17, 587-594
39. Seufferlein T. & Rozengurt E. (1995) Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein. Journal of Biological Chemistry 270, 24334-24342
40. Soboslay P.T., Dreweck C.M., Taylor H.R. et al. (1991) Experimental onchocerciasis in chimpanzees: cell-mediated immune responses and production and effects of IL-1 and IL-2 with Onchocerca volvulus infection. Journal of Immunology 147, 346-153
41. Stewart S.J., Cunningham G.R. & House F.S. (1993) Activation of phospholipase-D following perturbation of the human T-lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase-C. Cell Signal 5(3), 315-323
42. Stewart S.J., Cunningham G.R., Strupp J.A. et al. (1991) Activation of phospholipase D: a signalling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex. Cell Regulation 2, 841-845
43. Taylor-Fishwick D.A., June C.H. & Siegel J.N. (1997) Antigen receptor structure and signalling in T cells. In Lymphocyte Signalling, M.M. Harnett & K.P. Rigley, eds. John Wiley & Son, Chichester, UK, pp. 31-52
44. Vanamail P., Ramaiah K.D., Pani S.P. et al. (1996) Estimation of the fecund life-span of Wuchereria bancrofti in an endemic area. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 119-121
45. Wadee A.A., Vickery A.C. & Piessens W.F. (1987) Characterization of immunosuppressive proteins of Brugia malayi microfilariae. Acta Tropica 44, 343-352
46. Ward S.G., June C.H. & Olive D. (1996) Pl 3-kinase: A pivotal pathway in T-cell activation? Immunology Today 17, 187-197
47. Weil G.J. (1990) Parasite antigenemia in lymphatic filariasis. Experimental Parasitology 71, 353-356
48. Weiss N. (1978) Dipetalonema viteae: In vitro blastogenesis of hamster spleen and lymph node cells to phytohemagglutinin and filarial antigens. Experimental Parasitology 46, 283-299