Screening for mevalonate biosynthetic pathway inhibitors using sensitized bacterial strains

Journal of Biomolecular Screening

Volumn 16, Issue 6, 2011, Pages 637-646

  Ferrand, Sandrine ^a   Tao, Jianshi ^b   Shen, Xiaoyu ^b   McGuire, Dorothy ^b   Schmid, Andres ^a   Glickman, J Fraser ^a,c   Schopfer, Ulrich ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

high throughput screening; infectious disease; mevalonate pathway; optical density; Staphylococcus aureus

Indexed keywords

ANTIBIOTIC AGENT; CARBOXYLYASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; HYMEGLUSIN; ISOPENTENYL DIPHOSPHATE; ISOPROPYL THIOGALACTOSIDE; MEVALONATE DIPHOSPHATE DECARBOXYLASE; MEVALONATE KINASE; MEVALONIC ACID; PHOSPHOMEVALONATE KINASE; RIFAMPICIN; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; BIOSYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SCREENING; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MEVALONIC ACID; MICROBIAL SENSITIVITY TESTS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 79960532179     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111403927     Document Type: Article

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