Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 7, 2012, Pages 2382-2387

  Yonashiro, Ryo ^a   Kimijima, Yuya ^a   Shimura, Takuya ^a   Kawaguchi, Kohei ^a   Fukuda, Toshifumi ^a   Inatome, Ryoko ^a   Yanagi, Shigeru ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Neurodegenerative diseases; Oxidative stress

Indexed keywords

CALCIMYCIN; LIGASE; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1B LIGHT CHAIN 1; MITOCHONDRIAL UBIQUITIN LIGASE MITOL; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CYTOTOXICITY; DOWN REGULATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; MUTATIONAL ANALYSIS; NERVE CELL; NEUROPROTECTION; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

CELL DEATH; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEURONS; NITROSO COMPOUNDS; PROTEOLYSIS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84857132601     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114985109     Document Type: Article

References (36)

1. Calabrese V, et al. (2007) Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity. Nat Rev Neurosci 8:766-775. (Pubitemid 47462116)
2. Foster MW, Hess DT, Stamler JS (2009) Protein S-nitrosylation in health and disease: A current perspective. Trends Mol Med 15:391-404.
3. Dawson VL, Dawson TM (1996) Nitric oxide neurotoxicity. J Chem Neuroanat 10:179-190. (Pubitemid 26197684)
4. Seth D, Stamler JS (2011) The SNO-proteome: Causation and classifications. Curr Opin Chem Biol 15:129-136.
5. Shahani N, Sawa A (2011) Nitric oxide signaling and nitrosative stress in neurons: Role for S-nitrosylation. Antioxid Redox Signal 14:1493-1504.
6. Nakamura T, Lipton SA (2011) Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death Differ 18:1478-1486.
7. Benard G, et al. (2007) Mitochondrial bioenergetics and structural network organization. J Cell Sci 120:838-848.
8. Nakamura T, Lipton SA (2010) Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: Potential implications for Alzheimer's and Parkinson's diseases. Apoptosis 15:1354-1363.
9. Cho DH, et al. (2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324:102-105.
10. Riederer BM (2007) Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein. Brain Res Bull 71:541-558.
11. Liu L, Vo A, Liu G, McKeehan WL (2005) Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction. Cancer Res 65:4191-4201. (Pubitemid 40775657)
12. Stroissnigg H, et al. (2007) S-nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction. Nat Cell Biol 9:1035-1045. (Pubitemid 47338143)
13. Opal P, et al. (2003) Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis. J Biol Chem 278:34691-34699. (Pubitemid 37553319)
14. Jensen PH, et al. (2000) Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments. J Biol Chem 275:21500-21507. (Pubitemid 30481854)
15. Karbowski M, Neutzner A, Youle RJ (2007) The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol 178:71-84. (Pubitemid 47026403)
16. Nakamura N, Kimura Y, Tokuda M, Honda S, Hirose S (2006) MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep 7:1019-1022. (Pubitemid 44480517)
17. Sugiura A, et al. (2011) A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein. Mitochondrion 11:139-146.
18. Yonashiro R, et al. (2006) A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J 25:3618-3626. (Pubitemid 44264872)
19. Yonashiro R, et al. (2009) Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.Mol Biol Cell 20:4254-4530.
20. Allen E, et al. (2005) Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. Nature 438:224-228. (Pubitemid 41599874)
21. Yamanaka K, et al. (2003) Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Nat Cell Biol 5:336-340. (Pubitemid 36432298)
22. Yoshida Y, et al. (2002) E3 ubiquitin ligase that recognizes sugar chains. Nature 418:438-442. (Pubitemid 34826846)
23. Orian A, et al. (2000) SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J 19:2580-2591. (Pubitemid 30323547)
24. Palmer ZJ, et al. (2008) S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding. Biochem J 413:479-491.
25. Forrester MT, Foster MW, Benhar M, Stamler JS (2009) Detection of protein S-nitrosylation with the biotin-switch technique. Free Radic Biol Med 46:119-126.
26. Kawauchi T, Chihama K, Nishimura YV, Nabeshima Y, Hoshino M (2005) MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25, and JNK. Biochem Biophys Res Commun 331:50-55. (Pubitemid 40545140)
27. Schneider L, et al. (2011) Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress. Free Radic Biol Med 51:2007-2017.
28. Chung KK, et al. (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304:1328-1331. (Pubitemid 38697430)
29. Yao D, et al. (2004) Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci USA 101:10810-10814. (Pubitemid 38955824)
30. Kwak YD, et al. (2010) NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol Neurodegener 5:49.
31. Azad N, et al. (2006) S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis. J Biol Chem 281:34124-34134. (Pubitemid 46036621)
32. Jeyaraju DV, Cisbani G, Pellegrini L (2009) Calcium regulation of mitochondria motility and morphology. Biochim Biophys Acta 1787:1363-1373.
33. Rintoul GL, Bennett VJ, Papaconstandinou NA, Reynolds IJ (2006) Nitric oxide inhibits mitochondrial movement in forebrain neurons associated with disruption of mitochondrial membrane potential. J Neurochem 97:800-806.
34. Jiménez-Mateos EM, González-Billault C, Dawson HN, Vitek MP, Avila J (2006) Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J 397:53-59. (Pubitemid 44032836)
35. Nakamura T, Lipton SA (2007) S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding. Cell Death Differ 14:1305-1314. (Pubitemid 46969866)
36. Brown GC (2010) Nitric oxide and neuronal death. Nitric Oxide 23:153-165.