Targeted metabolic imaging to improve the management of heart disease

JACC: Cardiovascular Imaging

Volumn 5, Issue 2, 2012, Pages 214-226

  Osterholt, Moritz ^a   Sen, Shiraj ^a   Dilsizian, Vasken ^b   Taegtmeyer, Heinrich ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

Author keywords

cardiac metabolism; imaging; tracers

Indexed keywords

AMMONIA N 13; CARBON 13; FLUORODEOXYGLUCOSE F 18; IODOFILTIC ACID I 123; METHIONINE C 11; PALMITIC ACID C 11; PHOSPHORUS 31; THALLIUM 201; TRACER;

ARTICLE; CORONARY ARTERY BLOOD FLOW; HEART CONTRACTION; HEART DISEASE; HEART MUSCLE METABOLISM; HEART MUSCLE PERFUSION; HEART PERFORMANCE; HEART VENTRICLE REMODELING; HUMAN; IMAGING; KIDNEY FAILURE; METABOLIC IMAGING; OXYGEN TRANSPORT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 84857069529     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2011.11.009     Document Type: Review

References (91)

1. H. Taegtmeyer, R. Hems, H.A. Krebs Utilization of energy-providing substrates in the isolated working rat heart Biochem J 186 1980 701 711 (Pubitemid 10113089)
2. H. Taegtmeyer, L. Golfman, S. Sharma, P. Razeghi, M. van Arsdall Linking gene expression to function: metabolic flexibility in the normal and diseased heart Ann N Y Acad Sci 1015 2004 202 213 (Pubitemid 38879491)
3. A.M. Katz Molecular biology in cardiology, a paradigmatic shift J Mol Cell Cardiol 20 1988 355 366
4. H. Taegtmeyer Fueling the heart: multiple roles for cardiac metabolism J.T. Willerson, J.N. Cohn, H.J.J. Wellens, D.R. Holmes, Cardiovascular Medicine 3rd edition 2007 Springer-Verlag Ltd. London 1157 1175
5. J. Tillisch, R. Brunken, R. Marshall Reversibility of cardiac wall-motion abnormalities predicted by positron tomography N Engl J Med 314 1986 884 888 (Pubitemid 16126116)
6. M.F. Di Carli, M. Davidson, R. Little Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction Am J Cardiol 73 1994 527 533 (Pubitemid 24142581)
7. M. Di Carli, F. Asgarzadie, H.R. Schelbert Quantitative relation between myocardial viability and improvement in heart failure symptoms after revascularization in patients with ischemic cardiomyopathy Circulation 92 1995 3436 3444
8. N. Sorokina, J.M. O'Donnell, R.D. McKinney Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts Circulation 115 2007 2033 2041 (Pubitemid 46625954)
9. A.M. Katz Physiology of the Heart 5th ed. 2011 Lippincott, Williams & Wilkins Philadelphia, PA
10. P.J. Randle, P.B. Garland, C.N. Hales, E.A. Newsholme The glucose fatty-acid cycle Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1 1963 785 789
11. G.W. Goodwin, C.S. Taylor, H. Taegtmeyer Regulation of energy metabolism of the heart during acute increase in heart work J Biol Chem 273 1998 29530 29539 (Pubitemid 28509960)
12. S.H. Lee, P.L. Wolf, R. Escudero, R. Deutsch, S.W. Jamieson, P.A. Thistlethwaite Early expression of angiogenesis factors in acute myocardial ischemia and infarction N Engl J Med 342 2000 626 633 (Pubitemid 30118415)
13. C. Depre, G.L. Shipley, W. Chen Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy Nat Med 4 1998 1269 1275 (Pubitemid 28512107)
14. C. Depre, H. Taegtmeyer Metabolic aspects of programmed cell survival and cell death in the heart Cardiovasc Res 45 2000 538 548 (Pubitemid 30047120)
15. H. Taegtmeyer Modulation of responses to myocardial ischemia: metabolic features of myocardial stunning, hibernation and ischemic preconditioning V. Dilsizian, Myocardial Viability from Cellular Physiology to Clinical Decision Making 2000 Futura Publishing Co. New York 25 36
16. R.J. Gropler, E.M. Geltman, K. Sampathkumaran Functional recovery after coronary revascularization for chronic coronary artery disease is dependent on maintenance of oxidative metabolism J Am Coll Cardiol 20 1992 569 577
17. P. Herrero, A. Staudenherz, J.F. Walsh, R.J. Gropler, S.R. Bergmann Heterogeneity of myocardial perfusion provides the physiological basis of perfusable tissue index J Nucl Med 36 1995 320 327
18. H. Taegtmeyer The failing heart N Engl J Med 356 2007 2545 2546 author reply 6
19. N. Lane, W. Martin The energetics of genome complexity Nature 467 2010 929 934
20. C. Maack, B. O'Rourke Excitation-contraction coupling and mitochondrial energetics Basic Res Cardiol 102 2007 369 392 (Pubitemid 47278811)
21. V.T. Nguyen, K.A. Mossberg, T.J. Tewson Temporal analysis of myocardial glucose metabolism by 2-[18f]fluoro-2-deoxy-d-glucose Am J Physiol 259 1990 H1022 H1031
22. R. Schoenheimer The Dynamic State of Body Constituents 1942 Harvard University Press Cambridge, MA
23. H. Taegtmeyer Metabolic responses to cardiac hypoxia: increased production of succinate by rabbit papillary muscles Circ Res 43 1978 808 815 (Pubitemid 9054875)
24. R.J. Bing, A. Siegel, I. Ungar, M. Gilbert Metabolism of the human heart II. Studies on fat, ketone and amino acid metabolism Am J Med 16 1954 504 515
25. H.A. Krebs, P. Lund Aspects of the regulation of the metabolism of branched-chain amino acids Adv Enzyme Regul 15 1976 375 394
26. G. Lu, H. Sun, P. She Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells J Clin Invest 119 2009 1678 1687
27. Y. Huang, M. Zhou, H. Sun, Y. Wang Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit? Cardiovasc Res 90 2011 220 223
28. H. Taegtmeyer, M.B. Peterson, V.V. Ragavan, A.G. Ferguson, M. Lesch De novo alanine synthesis in isolated oxygen-deprived rabbit myocardium J Biol Chem 252 1977 5010 5018 (Pubitemid 8162216)
29. G.H. Mudge Jr., R.M. Mills Jr., H. Taegtmeyer, R. Gorlin, M. Lesch Alterations of myocardial amino acid metabolism in chronic ischemic heart disease J Clin Invest 58 1976 1185 1192
30. E. Henze, H.R. Schelbert, J.R. Barrio Evaluation of myocardial metabolism, with N-13- and C-11-labeled amino acids and positron computed tomography J Nucl Med 23 1982 671 681 (Pubitemid 12041274)
31. R. Zimmermann, H. Tillmans, W.H. Knapp Regional myocardial nitrogen-13 glutamate uptake in patients with coronary artery disease: inverse post-stress relation to thallium-201 uptake in ischemia J Am Coll Cardiol 11 1988 549 556 (Pubitemid 18060212)
32. 13 n] glutamate in the normal human heart and patients with coronary artery disease Eur J Nucl Med 7 1982 211 215 (Pubitemid 12113125)
33. J. Krivokapich, J.R. Barrio, S.C. Huang, H.R. Schelbert Dynamic positron tomographic imaging with nitrogen-13 glutamate in patients with coronary artery disease: comparison with nitrogen-13 ammonia and fluorine-18 fluorodeoxyglucose imaging J Am Coll Cardiol 16 1990 1158 1167 (Pubitemid 20378466)
34. M. Morooka, K. Kubota, H. Kadowaki 11C-methionine pet of acute myocardial infarction J Nucl Med 50 2009 1283 1287
35. H. Bolukoglu, G.W. Goodwin, P.H. Guthrie, S.G. Carmical, T.M. Chen, H. Taegtmeyer Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart Am J Physiol 270 1996 H817 H826
36. W. Stanley, J. Hall, C. Stone, T. Hacker Acute myocardial ischemia causes a transmural gradient in glucose extraction but not glucose uptake Am J Physiol 262 1992 H91 H96
37. J.R. Neely, L.W. Grotyohann Role of glycolytic products in damage to myocardium: dissociation of adenosine triphosphate levels and recovery of function of reperfused canine myocardium Circ Res 55 1984 816 824 (Pubitemid 15180282)
38. J.L. Vanoverschelde, M.F. Janier, J.E. Bakke, D.R. Marshall, S.R. Bergmann Rate of glycolysis during ischemia determines extent of ischemic injury and functional recovery after reperfusion Am J Physiol 267 1994 H1785 H1794
39. M. Shetty, J.N. Loeb, F. Ismail-Beigi Enhancement of glucose transport in response to inhibition of oxidative metabolism: pre- and post-translational mechanisms Am J Physiol 262 1992 C527 C532
40. N. Bashan, E. Burdett, A. Guma Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells Am J Physiol 264 1993 C430 C440
41. M. Shetty, N. Ismail-Beigi, J.N. Loeb, F. Ismail-Beigi Induction of GLUT1 mRNA in response to inhibition of oxidative phosphorylation Am J Physiol 265 1993 C1224 C1229
42. V. Dilsizian Myocardial Viability: A Clinical and Scientific Treatise 2000 Futura Publishing Company, Inc Armonk, NY
43. G. D'Egidio, G. Nichol, K.A. Williams PARR-2 Investigators Increasing benefit from revascularization is associated with increasing amounts of myocardial hibernation: a substudy of the PARR-2 Trial J Am Coll Cardiol Img 2 2009 1060 1068
44. K. Chatterjee Is detection of hibernating myocardium necessary in deciding revascularization in systolic heart failure? Am J Cardiol 106 2010 236 242
45. P.G. Camici, S.K. Prasad, O.E. Rimoldi Stunning, hibernation, and assessment of myocardial viability Circulation 117 2008 103 114 (Pubitemid 350301145)
46. V. Dilsizian Cardiac magnetic resonance versus SPECT: are all noninfarct myocardial regions created equal? J Nucl Cardiol 14 2007 9 14 (Pubitemid 46172885)
47. H.R. Schelbert, E. Henze, M.E. Phelps, D.E. Kuhl Assessment of regional myocardial ischemia by positron-emission computed tomography Am Heart J 103 1982 588 597 (Pubitemid 13139049)
48. M. Schwaiger, H. Schelbert, D. Ellison Sustained regional abnormalities in cardiac metabolism after transient ischemia in the chronic dog model J Am Coll Cardiol 6 1985 337 347
49. Y. Fujibayashi, Y. Yonekura, Y. Takemura Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl) -3-(r,s)methylpentadecanoic acid (BMIPP), in relation to ATP concentration J Nucl Med 31 1990 1818 1822 (Pubitemid 20374516)
50. R. Hosokawa, R. Nohara, Y. Fujibayashi Myocardial kinetics of iodine-123-BMIPP in canine myocardium after regional ischemia and reperfusion: implications for clinical SPECT J Nucl Med 38 1997 1857 1863 (Pubitemid 28030911)
51. I.C. Dormehl, N. Hugo, D. Rossouw, A. White, L.E. Feinendegen Planar myocardial imaging in the baboon model with iodine-123-15-(iodophenyl) pentadecanoic acid (IPPA) and iodine-123-15-(p-iodophenyl)-3-r,s- methylpentadecanoic acid (BMIPP), using time-activity curves for evaluation of metabolism Nucl Med Biol 22 1995 837 847
52. V. Dilsizian, T.M. Bateman, S.R. Bergmann Metabolic imaging with beta-methyl-p-[(123)I]-iodophenyl-pentadecanoic acid identifies ischemic memory after demand ischemia Circulation 112 2005 2169 2174 (Pubitemid 41475812)
53. Z. He, R. Shi, Y. Wu Direct imaging of exercise induced myocardial ischemia with fluorine-18 labeled deoxyglucose and tc-99m-sestamibi in coronary artery disease Circulation 108 2003 1208 1213 (Pubitemid 37099989)
54. 18 F-FDG uptake after exercise-induced myocardial ischemia in patients with coronary artery disease J Nucl Med 49 2008 1986 1991
55. 18 F-FDG uptake as a surrogate marker for antecedent ischemia J Nucl Med 49 2008 1909 1911
56. M.C. Kontos, V. Dilsizian, F. Weiland Iodofiltic acid I 123 (BMIPP) fatty acid imaging improves initial diagnosis in emergency department patients with suspected acute coronary syndromes: a multicenter trial J Am Coll Cardiol 56 2010 290 299
57. Y. Kawai, E. Tsukamoto, Y. Nozaki, K. Morita, M. Sakurai, N. Tamaki Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain J Am Coll Cardiol 38 2001 1888 1894 (Pubitemid 33116560)
58. H. Taegtmeyer, V. Dilsizian Imaging myocardial metabolism and ischemic memory Nat Clin Pract Cardiovasc Med 5 Suppl 2 2008 S42 S48
59. L.K. Steinbusch, R.W. Schwenk, D.M. Ouwens, M. Diamant, J.F. Glatz, J.J. Luiken Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes Cell Mol Life Sci 68 2011 2525 2538
60. N. Faergeman, J. Knudsen Role of long-chain fatty acyl-coA esters in the regulation of metabolism and in cell signalling Biochem J 323 1997 1 12 (Pubitemid 27153867)
61. L. Zhang, W. Keung, V. Samokhvalov, W. Wang, G.D. Lopaschuk Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle Biochim Biophys Acta 1801 2010 1 22
62. D.J. Glenn, F. Wang, M. Nishimoto A murine model of isolated cardiac steatosis leads to cardiomyopathy Hypertension 57 2011 216 222
63. J.M. McGavock, I. Lingvay, I. Zib Cardiac steatosis in diabetes mellitus: A 1H-magnetic resonance spectroscopy study Circulation 116 2007 1170 1175 (Pubitemid 47360218)
64. R.T. Brookheart, C.I. Michel, J.E. Schaffer As a matter of fat Cell Metab 10 2009 9 12
65. M.E. Griffin, M.J. Marcucci, G.W. Cline Free fatty acid-induced insulin resistance is associated with activation of protein kinase c theta and alterations in the insulin signaling cascade Diabetes 48 1999 1270 1274 (Pubitemid 29241025)
66. S.I. Itani, W.J. Pories, K.G. Macdonald, G.L. Dohm Increased protein kinase C theta in skeletal muscle of diabetic patients Metabolism 50 2001 553 557 (Pubitemid 32433044)
67. T.S. Park, Y. Hu, H.L. Noh Ceramide is a cardiotoxin in lipotoxic cardiomyopathy J Lipid Res 49 2008 2101 2112
68. E. Dirkx, R.W. Schwenk, J.F. Glatz, J.J. Luiken, G.J. van Eys High fat diet induced diabetic cardiomyopathy Prostaglandins Leukot Essent Fatty Acids 85 2011 219 225
69. N.H. Son, S. Yu, J. Tuinei PPAR-gamma-induced cardiolipotoxicity in mice is ameliorated by PPAR-alpha deficiency despite increases in fatty acid oxidation J Clin Invest 120 2010 3443 3454
70. V. Dilsizian, J.C. Fink Deleterious effect of altered myocardial fatty acid metabolism in kidney disease J Am Coll Cardiol 51 2008 146 148
71. A.E. Raine The heart and renal failure Contrib Nephrol 109 1994 76 83
72. A.E. Raine, A.M. Seymour, A.F. Roberts, G.K. Radda, J.G. Ledingham Impairment of cardiac function and energetics in experimental renal failure J Clin Invest 92 1993 2934 2940 (Pubitemid 24006564)
73. J. Coresh, E. Selvin, L.A. Stevens Prevalence of chronic kidney disease in the United States J Am Med Assn 298 2007 2038 2047 (Pubitemid 350074801)
74. United States Renal Data System USRDS 2006 Annual Data Report: Atlas of end-stage renal disease in the US Diseases National Institute of Diabetes and Digestive and Kidney Diseases 2006 National Institutes of Health Bethesda, MD
75. K. Tyralla, K. Amanna Morphology of the heart and arteries in renal failure Kidney Inst 63 2003 S80 S83
76. M. Nishimura, M. Murase, T. Hashimoto Insulin resistance and impaired myocardial fatty acid metabolism in dialysis patients with normal coronary arteries Kidney Int 69 2006 553 559 (Pubitemid 43164449)
77. J.C. Fink, M.A. Lodge, M.F. Smith Pre-clinical myocardial metabolic alterations in chronic kidney disease Cardiology 116 2010 160 167
78. M. Nishimura, K. Tsukamoto, N. Hasebe, N. Tamaki, K. Kikuchi, T. Ono Prediction of cardiac death in hemodialysis patients by myocardial fatty acid imaging J Am Coll Cardiol 51 2008 139 145
79. G. Paternostro, P.G. Camici, A.A. Lammertsma Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease A study with positron emission tomography J Clin Invest 98 1996 2094 2099 (Pubitemid 26376298)
80. M. Mki, M. Luotolahti, P. Nuutila Glucose uptake in the chronically dysfunctional but viable myocardium Circulation 93 1996 1658 1666 (Pubitemid 26131342)
81. D.F. Pauly, C.J. Pepine The role of carnitine in myocardial dysfunction Am J Kidney Dis 41 2003 S35 S43
82. T. Sakurabayashi, Y. Takaesu, S. Haginoshita Improvement of myocardial fatty acid metabolism through l-carnitine administration to chronic hemodialysis patients Am J Nephrol 19 1999 480 484 (Pubitemid 29397077)
83. Y. Fujibayashi, Y. Yonekura, K. Tamaki Myocardial accumulation of BMIPP in relation to ATP concentration Ann Nucl Med 7 Suppl 2 1993 15 18 (Pubitemid 24037553)
84. D.S. Wishart, C. Knox, A.C. Guo HMDB: a knowledgebase for the human metabolome Nucleic Acids Res 37 2009 D603 D610
85. J.R. Bain, R.D. Stevens, B.R. Wenner, O. Ilkayeva, D.M. Muoio, C.B. Newgard Metabolomics applied to diabetes research: moving from information to knowledge Diabetes 58 2009 2429 2443
86. S.H. Shah, J.R. Bain, M.J. Muehlbauer Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events Circ Cardiovasc Genet 3 2010 207 214
87. V.F. Segers, R.T. Lee Stem-cell therapy for cardiac disease Nature 451 2008 937 942 (Pubitemid 351301749)
88. J.F. Lau, S.A. Anderson, E. Adler, J.A. Frank Imaging approaches for the study of cell-based cardiac therapies Nat Rev Cardiol 7 2010 97 105
89. M. Hofmann, K.C. Wollert, G.P. Meyer Monitoring of bone marrow cell homing into the infarcted human myocardium Circulation 111 2005 2198 2202 (Pubitemid 40632435)
90. A.S. Lee, D. Xu, J.R. Plews Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells J Biol Chem 286 2011 32697 32704
91. A. Simioniuc, M. Campan, V. Lionetti Placental stem cells pre-treated with a hyaluronan mixed ester of butyric and retinoic acid to cure infarcted pig hearts: a multimodal study Cardiovasc Res 90 2011 546 556