Influence of the intracellular GluN2 C-terminal domain on NMDA receptor function

Neuropharmacology

Volumn 62, Issue 5-6, 2012, Pages 1985-1992

  Punnakkal, Pradeep ^a,b   Jendritza, Patrick ^a   Köhr, Georg ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Deactivation; Gating kinetics; Peak open probability; Rise time; Structural mechanism

Indexed keywords

GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; ELECTRIC CURRENT; EMBRYO; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; NEUROMODULATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SUBUNIT;

GLUTAMIC ACID; HEK293 CELLS; HUMANS; PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 84857064886     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.12.018     Document Type: Article

References (47)

1. T.G. Banke, and S.F. Traynelis Activation of NR1/NR2B NMDA receptors Nat. Neurosci. 6 2003 144 152 (Pubitemid 36182783)
2. D.M. Bannerman, B. Niewoehner, L. Lyon, C. Romberg, W.B. Schmitt, and A. Taylor NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory J. Neurosci. 28 2008 3623 3630
3. S. Berberich, V. Jensen, O. Hvalby, P.H. Seeburg, and G. Köhr The role of NMDAR subtypes and charge transfer during hippocampal LTP induction Neuropharmacology 52 2007 77 86 (Pubitemid 46026830)
4. C. Chen, and H. Okayama High-efficiency transformation of mammalian cells by plasmid DNA Mol. Cell Biol. 7 1987 2745 2752
5. N. Chen, T. Luo, and L.A. Raymond Subtype-dependence of NMDA receptor channel open probability J. Neurosci. 19 1999 6844 6854 (Pubitemid 29380113)
6. 2+ inhibition of the NMDA receptor Neuron 23 1999 171 180 (Pubitemid 29262474)
7. R.J. Clarke, and J.W. Johnson NMDA receptor NR2 subunit dependence of the slow component of magnesium unblock J. Neurosci. 26 2006 5825 5834 (Pubitemid 44315276)
8. G.L. Collingridge, J.T. Isaac, and Y.T. Wang Receptor trafficking and synaptic plasticity Nat. Rev. Neurosci. 5 2004 952 962 (Pubitemid 39593358)
9. S. Cull-Candy, S. Brickley, and M. Farrant NMDA receptor subunits: diversity, development and disease Curr. Opin. Neurobiol. 11 2001 327 335 (Pubitemid 32524098)
10. S.M. Dravid, A. Prakash, and S.F. Traynelis Activation of recombinant NR1/NR2C NMDA receptors J. Physiol. 586 2008 4425 4439
11. J.A. Dzubay, and C.E. Jahr Kinetics of NMDA channel opening J. Neurosci. 16 1996 4129 4134 (Pubitemid 26192408)
12. M.D. Ehlers, S. Zhang, J.P. Bernhadt, and R.L. Huganir Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit Cell 84 1996 745 755 (Pubitemid 26094204)
13. K. Erreger, S.M. Dravid, T.G. Banke, D.J. Wyllie, and S.F. Traynelis Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles J. Physiol. 563 2005 345 358 (Pubitemid 40360896)
14. 2+ binding to NMDA receptors Neuron 25 2000 683 694
15. H. Furukawa, S.K. Singh, R. Mancusso, and E. Gouaux Subunit arrangement and function in NMDA receptors Nature 438 2005 185 192 (Pubitemid 41599865)
16. M. Gielen, B. Siegler Retchless, L. Mony, J.W. Johnson, and P. Paoletti Mechanism of differential control of NMDA receptor activity by NR2 subunits Nature 459 2009 703 707
17. J.E. Huettner, and B.P. Bean Block of N-methyl-d-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels Proc. Natl. Acad. Sci. U. S. A. 85 1988 1307 1311 (Pubitemid 18073998)
18. C.E. Jahr High probability opening of NMDA receptor channels by l-glutamate Science 255 1992 470 472
19. G. Köhr NMDA receptor function: subunit composition versus spatial distribution Cell Tissue Res. 326 2006 439 446 (Pubitemid 44435819)
20. G. Köhr, S. Eckardt, H. Luddens, H. Monyer, and P.H. Seeburg NMDA receptor channels: subunit-specific potentiation by reducing agents Neuron 12 1994 1031 1040 (Pubitemid 24178195)
21. G. Köhr, V. Jensen, H.J. Koester, A.L. Mihaljevic, J.K. Utvik, A. Kvello, O.P. Ottersen, P.H. Seeburg, R. Sprengel, and O. Hvalby Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction J. Neurosci. 23 2003 10791 10799 (Pubitemid 37499685)
22. G. Köhr, and P.H. Seeburg Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the Src family J. Physiol. (Lond.) 1996 445 452 (Pubitemid 26137754)
23. E. Karakas, N. Simorowski, and H. Furukawa Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors Nature 475 2011 249 253
24. E. Kim, and M. Sheng PDZ domain proteins of synapses Nat. Rev. Neurosci. 5 2004 771 781 (Pubitemid 39336214)
25. 2+-dependent inactivation of NMDA receptors J. Neurosci. 19 1999 1165 1178 (Pubitemid 29088900)
26. C.G. Lau, and R.S. Zukin NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders Nat. Rev. Neurosci. 8 2007 413 426 (Pubitemid 46789232)
27. D.N. Lieberman, and I. Mody Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase Nature 369 1994 235 239 (Pubitemid 24154801)
28. C.M. Low, F. Zheng, P. Lyuboslavsky, and S.F. Traynelis Molecular determinants of coordinated proton and zinc inhibition of N-methyl-d-aspartate NR1/NR2A receptors Proc. Natl. Acad. Sci. U. S. A. 97 2000 11062 11067
29. Y.M. Lu, J.C. Roder, J. Davidow, and M.W. Salter Src activation in the induction of long-term potentiation in CA1 hippocampal neurons Science 279 1998 1363 1367 (Pubitemid 28119580)
30. R.C. Malenka, and R.A. Nicoll Long-term potentiation - a decade of progress? Science 285 1999 1870 1874
31. R. Mohrmann, G. Köhr, H. Hatt, R. Sprengel, and K. Gottmann Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-d-aspartate receptors in nascent neocortical synapses J. Neurosci. Res. 68 2002 265 275 (Pubitemid 34462531)
32. H. Monyer, N. Burnashev, D.J. Laurie, B. Sakmann, and P.H. Seeburg Developmental and regional expression in the rat brain and functional properties of four NMDA receptors Neuron 12 1994 529 540 (Pubitemid 24100885)
33. P. Paoletti Molecular basis of NMDA receptor functional diversity Eur. J. Neurosci. 33 2011 1351 1365
34. C.A. Puddifoot, P.E. Chen, R. Schoepfer, and D.J. Wyllie Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes Br. J. Pharmacol. 156 2009 509 518
35. 2+ and ATP J. Physiol. 470 1993 705 729 (Pubitemid 23322515)
36. C. Rosenmund, A. Feltz, and G.L. Westbrook Synaptic NMDA receptor channels have a low open probability J. Neurosci. 15 1995 2788 2795
37. P. Rossi, E. Sola, V. Taglietti, T. Borchardt, F. Steigerwald, and J.K. Utvik NMDA receptor 2 (NR2) C-terminal control of NR open probability regulates synaptic transmission and plasticity at a cerebellar synapse J. Neurosci. 22 2002 9687 9697 (Pubitemid 35332852)
38. M.W. Salter, and L.V. Kalia Src kinases: a hub for NMDA receptor regulation Nat. Rev. Neurosci. 5 2004 317 328 (Pubitemid 38478658)
39. R. Sprengel, B. Suchanek, C. Amico, R. Brusa, N. Burnashev, and A. Rozov Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo Cell 92 1998 279 289 (Pubitemid 28073050)
40. F. Steigerwald, T.W. Schulz, L.T. Schenker, M.B. Kennedy, P.H. Seeburg, and G. Köhr C-terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors J. Neurosci. 20 2000 4573 4581 (Pubitemid 30396623)
41. S.F. Traynelis, L.P. Wollmuth, C.J. McBain, F.S. Menniti, K.M. Vance, and K.K. Ogden Glutamate receptor ion channels: structure, regulation, and function Pharmacol. Rev. 62 2010 405 496
42. S. Vicini, J.F. Wang, J.H. Li, W.J. Zhu, Y.H. Wang, and J.H. Luo Functional and pharmacological differences between recombinant N-methyl-d-aspartate receptors J. Neurophysiol. 79 1998 555 566 (Pubitemid 28095877)
43. Z.G. Xiong, K.A. Pelkey, W.Y. Lu, Y.M. Lu, J.C. Roder, and J.F. MacDonald Src potentiation of NMDA receptors in hippocampal and spinal neurons is not mediated by reducing zinc inhibition J. Neurosci. 19 1999 RC37
44. X.M. Yu, R. Askalan, G.J. Keil 2nd, and M.W. Salter NMDA channel regulation by channel-associated protein tyrosine kinase Src Science 275 1997 674 678 (Pubitemid 27061336)
45. H. Yuan, K.B. Hansen, K.M. Vance, K.K. Ogden, and S.F. Traynelis Control of NMDA receptor function by the NR2 subunit amino-terminal domain J. Neurosci. 29 2009 12045 12058
46. S. Zhang, M.D. Ehlers, J.P. Bernhardt, C.T. Su, and R.L. Huganir Calmodulin mediates calcium-dependent inactivation of N-methyl-d-aspartate receptors Neuron 21 1998 443 453 (Pubitemid 28399704)
47. F. Zheng, M.B. Gingrich, S.F. Traynelis, and P.J. Conn Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition Nat. Neurosci. 1 1998 185 191