Human and rat hepatocyte toxicity and protein phosphatase 1 and 2A inhibitory activity of naturally occurring desmethyl-microcystins and nodularins

Toxicology

Volumn 293, Issue 1-3, 2012, Pages 59-67

  Ufelmann, Helena ^a   Krüger, Thomas ^b   Luckas, Bernd ^b   Schrenk, Dieter ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Cyanobacteria; Hepatocytes; Liver toxicity; Microcystins; Nodularin; Protein phosphatases

Indexed keywords

ASPARTIC ACID; MICROCYSTIN; NODULARIN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A;

ALGAL BLOOM; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL DAMAGE; METHYLATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; ENZYME INHIBITORS; GERMANY; HARMFUL ALGAL BLOOM; HEPATOCYTES; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; KINETICS; MALE; MARINE TOXINS; METHYLATION; MICROCYSTINS; MICROCYSTIS; NODULARIA; PEPTIDES, CYCLIC; PROTEIN PHOSPHATASE 1; PROTEIN PHOSPHATASE 2; RATS; RATS, WISTAR;

ALGAE; ANIMALIA; BOVINAE; CYANOBACTERIA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 84857064685     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.12.011     Document Type: Article

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