A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: A potential disease-modifying drug for osteoarthritis therapeutics

Journal of Clinical Immunology

Volumn 31, Issue 6, 2011, Pages 1131-1142

  Liu, Feng Cheng ^a,b   Huang, Hsu Shan ^a   Huang, Chuan Yueh ^c   Yang, Ro ^a   Chang, Deh Ming ^a,b   Lai, Jenn Haung ^a,b   Ho, Ling Jun ^c,d  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Chondrocytes; Inflammation; Interferon regulatory factor 1; Osteoarthritis; Small molecule; Tumor necrosis factor alpha

Indexed keywords

2 HYDROXY N [3 (TRIFLUOROMETHYL)PHENY]BENZAMIDE; AGGRECANASE; AGGRECANASE 1; AGGRECANASE 2; BENZAMIDE DERIVATIVE; COLLAGEN TYPE 2; COLLAGENASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; MATRIX METALLOPROTEINASE; NITRIC OXIDE; PROTEOGLYCAN; SHORT HAIRPIN RNA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOASSAY; CARTILAGE CELL; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY TEST; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; EXPERIMENTAL PIG; EXPLANT; HISTOCHEMISTRY; IMMUNOMODULATION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ZYMOGRAPHY;

ANIMALS; BENZAMIDES; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; GENE EXPRESSION REGULATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON REGULATORY FACTOR-1; JOINTS; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SWINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84857054809     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-011-9576-9     Document Type: Article

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