Metabolic syndrome potentiates the cardiac action potential-prolonging action of drugs: A possible 'anti-proarrhythmic' role for amlodipine

Pharmacological Research

Volumn 65, Issue 3, 2012, Pages 320-327

  Caillier, Bertrand ^a,b   Pilote, Sylvie ^b   Patoine, Dany ^b   Levac, Xavier ^a,b   Couture, Christian ^a,b   Daleau, Pascal ^a,b   Simard, Chantale ^a,b   Drolet, Benoit ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Amlodipine; Cardiac action potentials; Drugs; Metabolic syndrome

Indexed keywords

AMLODIPINE; CHOLESTEROL; CHROMANOL 293B; DOFETILIDE; GLUCOSE; TRIACYLGLYCEROL; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET; DISEASE ACTIVITY; DRUG MECHANISM; DRUG POTENTIATION; EX VIVO STUDY; GLUCOSE TOLERANCE; GUINEA PIG; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HISTOPATHOLOGY; ISOLATED HEART; MALE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; TARGET ORGAN; TORSADE DES POINTES; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL;

AMLODIPINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; DIET, HIGH-FAT; ELECTROCARDIOGRAPHY; GUINEA PIGS; HEART; MALE; METABOLIC SYNDROME X;

EID: 84857048311     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.11.015     Document Type: Article

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