Molecular biology of water and salt regulation in the kidney

Cellular and Molecular Life Sciences

Volumn 69, Issue 5, 2012, Pages 683-695

  Esteva Font, C ^a   Ballarin, J ^a   Fernandez Llama P ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Aquaporins; Sodium channels; Sodium transporters; Water channels

Indexed keywords

AQUAPORIN; AQUAPORIN 1; AQUAPORIN 11; AQUAPORIN 2; AQUAPORIN 3; AQUAPORIN 4; AQUAPORIN 6; AQUAPORIN 7; CARRIER PROTEIN; PROTEIN KINASE; PROTEIN KINASE WNK1; PROTEIN KINASE WNK3; PROTEIN KINASE WNK4; PROTEIN NKCC2; SODIUM CHANNEL; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WATER;

ENDOCYTOSIS; EXTRACELLULAR MATRIX; FLUID BALANCE; HENLE LOOP; HUMAN; HYPERTENSION; HYPONATREMIA; HYPOTENSION; KIDNEY DISTAL TUBULE; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; KIDNEY TUBULE ABSORPTION; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SODIUM BALANCE; SODIUM RETENTION; SODIUM TRANSPORT; WATER PERMEABILITY; WATER TRANSPORT;

ANIMALS; AQUAPORINS; HUMANS; ION TRANSPORT; KIDNEY TUBULES; SODIUM; SODIUM CHANNELS; WATER;

EID: 84857047826     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0858-4     Document Type: Review

References (73)

1. Knepper MA, Stephenson JL (1986) Urinary concentrating and diluting processes. In Andreoli TE (ed) Physiology of membrane disorders, 2nd edn. Plenum, New York, pp 713-726
2. Nielsen S, Agre P (1995) The aquaporin family of water channels in kidney. Kidney Int 48:1057-1068
3. Verkman AS (2009) Aquaporins: translating bench research to human disease. J Exp Biol 212:1707-1715
4. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS (2005) Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci 118:5691-5698 (Pubitemid 43079263)
5. González-Campoy JM, Knox FG (1992) Integrated responses of the kidney to alterations in extracellular fluid volume. In Seldin DW et al (eds) The kidney: physiology and pathophysiology. Raven Press, New York, pp 2041-2098
6. Shepherd JT (1992) Cardiac mechanoreceptors. In Fozzard HA et al (eds) The heart and cardiovascular system. Raven Press, New York, pp 1481-1504
7. Schnermann J (2000) NaCl transport deficiencies-hemodynamics to the rescue. Pflugers Arch 439:682-690
8. Knepper MA, Brooks HL (2001) Regulation of the sodium transporters NHE3, NKCC2 and NCC in the kidney. Curr Opin Nephrol Hypertens 10:655-659 (Pubitemid 32783817)
9. Pallone TL, Edwards A, Ma T, Silldorff EP, Verkman AS (2000) Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest 105:215-222 (Pubitemid 30054361)
10. King LS, Choi M, Fernandez PC, Cartron JP, Agre P (2001) Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1. N Engl J Med 345:175-179 (Pubitemid 32662126)
11. Hara-Chikuma M, Verkman AS (2006) Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule. J Am Soc Nephrol 17:39-45
12. Morrissey JJ, London AN, Luo J, Kharasch ED (2010) Urinary biomarkers for the early diagnosis of kidney cancer. Mayo Clin Proc 85:413-421
13. Nejsum LN, Elkjaer M, Hager H, Frokiaer J, Kwon TH, Nielsen S (2000) Localization of aquaporin-7 in rat and mouse kidney using RT-PCR, immunoblotting, and immunocytochemistry. Biochem Biophys Res Commun 277:164-170
14. Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S (2005) Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol 289:F1195-F1200 (Pubitemid 41681354)
15. Morishita Y, Matsuzaki T, Hara-Chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K (2005) Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol 25:7770-7779 (Pubitemid 41170137)
16. Riquier-Brison AD, Leong PK, Pihakaski-Maunsbach K, Mc-Donough AA (2010) Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol 298:F177-F186
17. McDonough AA (2010) Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol 298:R851-R861
18. Nakamura S, Amlal H, Schultheis PJ, Galla JH, Shull GE, Soleimani M (1999) HCO-3 reabsorption in renal collecting duct of NHE-3-deficient mouse: a compensatory response. Am J Physiol 276:F914-F921 (Pubitemid 29323565)
19. Bergwitz C, Roslin NM, Tieder M, Loredo-Osti JC, Bastepe M, bu-Zahra H, Frappier D, Burkett K, Carpenter TO, Anderson D, Garabedian M, Sermet I, Fujiwara TM, Morgan K, Tenenhouse HS, Juppner H (2006) SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. Am J Hum Genet 78:179-192 (Pubitemid 43157559)
20. Miyamoto K, Ito M, Tatsumi S, Kuwahata M, Segawa H (2007) New aspect of renal phosphate reabsorption: the type IIc sodiumdependent phosphate transporter. Am J Nephrol 27:503-515 (Pubitemid 47482008)
21. Castrop H, Schnermann J (2008) Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance. Am J Physiol Renal Physiol 295:F859-F866
22. Greger R (2000) Physiology of renal sodium transport. Am J Med Sci 319:51-62 (Pubitemid 30367874)
23. Hoorn EJ, Nelson JH, McCormick JA, Ellison DH (2011) The WNK kinase network regulating sodium, potassium, and blood pressure. J Am Soc Nephrol 22:605-614
24. Reiche J, Theilig F, Rafiqi FH, Carlo AS, Militz D, Mutig K, Todiras M, Christensen EI, Ellison DH, Bader M, Nykjaer A, Bachmann S, Alessi D, Willnow TE (2010) SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(?)-K(?)-Cl(-) cotransporter 2. Mol Cell Biol 30:3027-3037
25. Starremans PG, Kersten FF, Knoers NV, van den Heuvel LP, Bindels RJ (2003) Mutations in the human Na-K-2Cl cotransporter (NKCC2) identified in Bartter syndrome type I consistently result in nonfunctional transporters. J Am Soc Nephrol 14:1419-1426 (Pubitemid 36687042)
26. Hebert SC (2003) Bartter syndrome. Curr Opin Nephrol Hypertens 12:527-532 (Pubitemid 37083114)
27. Glover M, O'Shaughnessy KM (2011) SPAK and WNK kinases: a new target for blood pressure treatment? Curr Opin Nephrol Hypertens 20:16-22
28. Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, Cai H (2010) WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J Am Soc Nephrol 21:82-92
29. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA (1998) The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci U S A 95:14552-14557 (Pubitemid 28549405)
30. Verlander JW, Tran TM, Zhang L, Kaplan MR, Hebert SC (1998) Estradiol enhances thiazide-sensitive NaCl cotransporter density in the apical plasma membrane of the distal convoluted tubule in ovariectomized rats. J Clin Invest 101:1661-1669 (Pubitemid 28198495)
31. Gamba G (2005) Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension. Am J Physiol Renal Physiol 288:F245-F252 (Pubitemid 40105382)
32. Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH (2010) SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol 21:1868-1877
33. Gamba G (2009) The thiazide-sensitive Na?-Cl-cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol 297:F838-F848
34. Valenti G, Procino G, Tamma G, Carmosino M, Svelto M (2005) Minireview: aquaporin 2 trafficking. Endocrinology 146:5063-5070 (Pubitemid 41653018)
35. Chou CL, Christensen BM, Frische S, Vorum H, Desai RA, Hoffert JD, de Lanerolle P, Nielsen S, Knepper MA (2004) Nonmuscle myosin II and myosin light chain kinase are downstream targets for vasopressin signaling in the renal collecting duct. J Biol Chem 279:49026-49035 (Pubitemid 39625784)
36. Chou CL, Yip KP, Michea L, Kador K, Ferraris J, Wade JB, Knepper MA (2000) Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct. Roles of ryanodinesensitive Ca2? stores and calmodulin. J Biol Chem 275:36839-36846 (Pubitemid 32002095)
37. Brown D, Hasler U, Nunes P, Bouley R, Lu HA (2008) Phosphorylation events and the modulation of aquaporin 2 cell surface expression. Curr Opin Nephrol Hypertens 17:491-498
38. Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D (2008) The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol 295:F290-F294
39. Xie L, Hoffert JD, Chou CL, Yu MJ, Pisitkun T, Knepper MA, Fenton RA (2010) Quantitative analysis of aquaporin-2 phosphorylation. Am J Physiol Renal Physiol 298:F1018-F1023
40. Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T (2008) Localization and trafficking of aquaporin 2 in the kidney. Histochem Cell Biol 130:197-209
41. Noda Y, Sohara E, Ohta E, Sasaki S (2010) Aquaporins in kidney pathophysiology. Nat Rev Nephrol 6:168-178
42. Boone M, Deen PM (2008) Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Pflugers Arch 456:1005-1024
43. Yasui M, Zelenin SM, Celsi G, Aperia A (1997) Adenylate cyclase-coupled vasopressin activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol 272:F443-F450
44. Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D (2008) Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem 283:26643-26661
45. Khositseth S, Pisitkun T, Slentz DH, Wang G, Hoffert JD, Knepper MA, Yu MJ (2011) Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells. Mol Cell Proteomics 10:M110
46. Loonen AJ, Knoers NV, van Os CH, Deen PM (2008) Aquaporin 2 mutations in nephrogenic diabetes insipidus. Semin Nephrol 28:252-265 (Pubitemid 351749753)
47. Fernandez-Llama P, Turner R, DiBona G, Knepper M (1999) Renal expression of aquaporins in liver cirrhosis induced by chronic bile duct ligation in rats. J Am Soc Nephrol 10:1950-1957 (Pubitemid 29402516)
48. Fernandez-Llama P, Jimenez W, Bosch-Marce M, Arroyo V, Nielsen S, Knepper MA (2000) Dysregulation of renal aquaporins and Na-Cl cotransporter in CCl4-induced cirrhosis. Kidney Int 58:216-228 (Pubitemid 30429866)
49. Kanno K, Sasaki S, Hirata Y, Ishikawa S, Fushimi K, Nakanishi S, Bichet DG, Marumo F (1995) Urinary excretion of aquaporin-2 in patients with diabetes insipidus. N Engl J Med 332: 1540-1545
50. Pedersen RS, Bentzen H, Bech JN, Nyvad O, Pedersen EB (2003) Urinary aquaporin-2 in healthy humans and patients with liver cirrhosis and chronic heart failure during baseline conditions and after acute water load. Kidney Int 63:1417-1425 (Pubitemid 36350006)
51. Esteva-Font C, Baccaro ME, Fernandez-Llama P, Sans L, Guevara M, Ars E, Jimenez W, Arroyo V, Ballarin JA, Gines P (2006) Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: relationship with ascites and hepatorenal syndrome. Hepatology 44:1555-1563 (Pubitemid 44953660)
52. Fernandez-Llama P, Andrews P, Nielsen S, Ecelbarger CA, Knepper MA (1998) Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome. Kidney Int 53:1244-1253 (Pubitemid 28316885)
53. Apostol E, Ecelbarger CA, Terris T, Bradford AD, Andrews P, Knepper MA (1997) Reduced renal medullary water channel expression in puromycin aminonucleoside-induced nephrotic syndrome. J Am Soc Nephrol 8:15-24 (Pubitemid 27496511)
54. Radetti G, Paganini C, Rigon F, Gentili L, Gebert U, Ishikawa S (2001) Urinary aquaporin-2 excretion in nocturnal enuresis. Eur J Endocrinol 145:435-438 (Pubitemid 32927070)
55. Ecelbarger CA, Murase T, Tian Y, Nielsen S, Knepper MA, Verbalis JG (2002) Regulation of renal salt and water transporters during vasopressin escape. Prog Brain Res 139:75-84 (Pubitemid 35460881)
56. Kwon TH, Nielsen J, Masilamani S, Hager H, Knepper MA, Frokiaer J, Nielsen S (2002) Regulation of collecting duct AQP3 expression: response to mineralocorticoid. Am J Physiol Renal Physiol 283:F1403-F1421 (Pubitemid 35332668)
57. Zelenina M, Tritto S, Bondar AA, Zelenin S, Aperia A (2004) Copper inhibits the water and glycerol permeability of aquaporin Biol Chem 279 J.51939-51943 (Pubitemid 39656562)
58. Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (2000) Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A 97:4386-4391 (Pubitemid 30226142)
59. Zhao D, Bankir L, Qian L, Yang D, Yang B (2006) Urea and urine concentrating ability in mice lacking AQP1 and AQP3. Am J Physiol Renal Physiol 291:F429-F438 (Pubitemid 44148133)
60. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (1997) Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest 100:957-962 (Pubitemid 27386279)
61. Zelenina M, Zelenin S, Bondar AA, Brismar H, Aperia A (2002) Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine. Am J Physiol Renal Physiol 283:F309-F318 (Pubitemid 34778994)
62. Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, van Hoek AN (2004) Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol 287:F501-F511 (Pubitemid 39095965)
63. Beitz E, Liu K, Ikeda M, Guggino WB, Agre P, Yasui M (2006) Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells. Biol Cell 98:101-109 (Pubitemid 43230620)
64. Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA (1999) Aldosterone-mediated regulation of ENaC a, b, and c subunit proteins in rat kidney. J Clin Invest 104:R19-R23 (Pubitemid 29536348)
65. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V (2006) (Patho)physiological significance of the serumand glucocorticoid-inducible kinase isoforms. Physiol Rev 86:1151-1178 (Pubitemid 44521650)
66. Butterworth MB (2010) Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. Biochim Biophys Acta 1802:1166-1177
67. Karpushev AV, Levchenko V, Pavlov TS, Lam VY, Vinnakota KC, Vandewalle A, Wakatsuki T, Staruschenko A (2008) Regulation of ENaC expression at the cell surface by Rab11. Biochem Biophys Res Commun 377:521-525
68. Hamm LL, Feng Z, Hering-Smith KS (2010) Regulation of sodium transport by ENaC in the kidney. Curr Opin Nephrol Hypertens 19:98-105
69. Loffing J, Korbmacher C (2009) Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflugers Arch 458:111-135
70. Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zeiher BG, Stokes JB, Welsh MJ (1995) Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na? channel. Cell 83:969-978 (Pubitemid 26006538)
71. Chang SS, Grunder S, Hanukoglu A, Rosler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelson-Williams C, Rossier BC, Lifton RP (1996) Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet 12:248-253 (Pubitemid 26080082)
72. Hummler E, Vallon V (2005) Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins. J Am Soc Nephrol 16:3160-3166 (Pubitemid 46179322)
73. Eladari D, Hubner CA (2011) Novel mechanisms for NaCl reabsorption in the collecting duct. Curr Opin Nephrol Hypertens 20:506-511